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Publikováno v:
Mutagenesis. 17:383-389
Dacarbazine (DTIC) is a chemotherapeutic agent that has been successfully applied to treat various types of cancer such as Hodgkin's disease, malignant melanomas, soft tissue sarcomas and advanced neuroblastomas. Many of the patients are of reproduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31869683835057928a5db44f03ee1f88
https://doi.org/10.1093/mutage/17.5.383
https://doi.org/10.1093/mutage/17.5.383
Autor:
James M Parry, E.M Parry, R Boumer, A Doherty, S Ellard, J O'Donovan, B Hoebee, J.M de Stoppelaar, G.R Mohn, A Önfelt, A Renglin, N Schultz, C Soderpalm-Bemdes, K.G Jensen, M Kirsch-Volders, A Elhajouji, P Van Hummelen, F Degrassi, A Antoccia, D Cimini, M Izzo, C Tanzarella, I.-D Adler, U Kliesch, G Schriever-Schwemmer, P Gasser, R Crebelli, A Carere, C Andreoli, R Benigni, P Leopardi, F Marcon, Z Zinjo, A.T Natarajan, J.J.W.A Boei, A Kappas, G Voutsinas, F.E Zarani, A Patrinelli, F Pachierotti, C Tiveron, P Hess
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 353:11-46
Although aneuploidy makes a significant contribution to both somatic and inherited disease the mechanisms by which environmental chemicals may induce numerical chromosome aberrations are only poorly defined. The European Union Project was aimed to fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e231cb2bd83ffe6973dcae89ac793278
https://doi.org/10.1016/0027-5107(95)00242-1
https://doi.org/10.1016/0027-5107(95)00242-1
Publikováno v:
Mutagenesis. 10:535-542
The bifunctional metabolite of 1,3-butadiene, 1,2 :3,4-diepoxybutane (DEB), was tested in the mouse bone marrow micronucleus assay and in male mouse germ cell tests, namely the analysis of first cleavage divisions and the dominant lethal assay. All e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa9d75ffa67ebaf340928d85882a805
https://doi.org/10.1093/mutage/10.6.535
https://doi.org/10.1093/mutage/10.6.535
Autor:
I.-D. Adler, U. Kliesch
Publikováno v:
Mutation Research Letters. 283:249-253
The clastogenic effect of the antischistosomal drug hycanthone methanesulfonate was studied with the micronucleus test in mouse bone marrow cells. Male and female (102/El x C3H/El)F1 mice were treated with single i.p. injections. Bone marrow was samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a4b371a7c6c23d90606a928601b57
https://doi.org/10.1016/0165-7992(92)90056-n
https://doi.org/10.1016/0165-7992(92)90056-n
Autor:
I.-D. Adler, U. Kliesch
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 234:115-123
Three experiments are reported as a contribution to the validation of the multiple treatment protocol presently under discussion. (1) In the single treatment experiment with hydroquinone (HQ) the time of maximum micronucleus response was determined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8833983ee0c3bb3dd3bcd8e20f885263
https://doi.org/10.1016/0165-1161(90)90002-6
https://doi.org/10.1016/0165-1161(90)90002-6
Autor:
G. Schriever-Schwemmer, Osama A. Badary, Farid M. Hamada, Ilse-Dore Adler, Sabry M. Attia, U. Kliesch
Publikováno v:
Environmental and molecular mutagenesis. 41(2)
The topoisomerase II (topo II) inhibitors etoposide (VP-16) and merbarone (MER) were investigated with the in vivo micronucleus test (MN test) combined with fluorescence in situ hybridization (FISH) using the mouse minor satellite DNA probe to discri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e275a788a5ea60121ec150ceed9852b4
https://pubmed.ncbi.nlm.nih.gov/12605378
https://pubmed.ncbi.nlm.nih.gov/12605378
Publikováno v:
Mutagenesis. 12(5)
Three metabolites of 1,3-butadiene, namely butadiene diolepoxide, butadiene monoepoxide and diepoxybutane, were tested in the bacterial mutation assay using Salmonella typhimurium strain TA100 with and without metabolic activation (S9 mix). All three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbcb7792ea2c4a84f2e2836ee282e3e
https://pubmed.ncbi.nlm.nih.gov/9379912
https://pubmed.ncbi.nlm.nih.gov/9379912
Publikováno v:
Mutation research. 349(2)
isoPropyl methanesulphonate (iPMS) and its n-propyl analogue (nPMS) are shown to be active in mouse bone marrow micronucleus assays using male CBA, male and female (C3H/El X 102/E1)Fl and male and female Muta Mouse mice. iPMS was significantly more a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ec6591e88ab395455a9539dd6b6b8c
https://pubmed.ncbi.nlm.nih.gov/8600355
https://pubmed.ncbi.nlm.nih.gov/8600355
Autor:
Johannes G. Filser, A. Neuhäuser-Klaus, J. Cao, Ilse-Dore Adler, U. Kliesch, W. Kessler, M. Nüsse, P. Gassner
Publikováno v:
Mutation research. 309(2)
Inhalation exposure of mice to 50, 200, 500 or 1300 ppm of 1,3-butadiene for 6 h per day for 5 consecutive days caused micronuclei in mouse bone marrow and peripheral blood erythrocytes. The dose response was non-linear. The slope of the curve flatte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c179a0403557be17b98dbc215e6922d
https://pubmed.ncbi.nlm.nih.gov/7520990
https://pubmed.ncbi.nlm.nih.gov/7520990