Zobrazeno 1 - 10
of 80
pro vyhledávání: '"U. Kasid"'
Publikováno v:
Biochemical and Biophysical Research Communications. 190:462-469
Oncogenic activation of the human c- raf -1 protein (Raf-l) occurs by truncation of its aminoterminus (regulatory domain) and retention of the carboxyterminus (kinase domain). To gain insight into the structure of human raf -1 genomic DNA correspondi
Publikováno v:
Genome Research. 1:171-174
Modified PCR amplification and direct sequencing procedures for the double-stranded genomic DNA template are described. Advantages of the approach we describe are: background artifact bands previously observed using high-molecular-weight DNA as a tem
Publikováno v:
Anticancer research. 21(5)
We describe here the preclinical studies of a novel formulation of liposome-entrapped mitoxantrone (LEM). The liposome entrapment efficiency of mitoxantrone was 93.4 +/- 2.8%. In vitro cytotoxicity studies in HL60 cells comparing LEM with conventiona
Autor:
R L, Meighan-Mantha, A T, Riegel, S, Suy, V, Harris, F H, Wang, C, Lozano, T L, Whiteside, U, Kasid
Publikováno v:
Molecular and cellular biochemistry. 199(1-2)
In mammalian cells, the octamer motif (ATGCAAAT) binding proteins, Oct-1 and Oct-2, play an important role in the transcriptional transactivation of several ubiquitously expressed genes as well as cell-specifically expressed genes. To date, a role of
Publikováno v:
Molecular and cellular biochemistry. 173(1-2)
Exposure of cells to ionizing radiation (IR) or tumor necrosis factor-alpha (TNF-alpha) results in the stimulation of the DNA binding activities of transcription factors, AP-1 and NF-kappaB. HVH1/CL100, a dual specificity protein phosphatase, may att
Publikováno v:
Molecular carcinogenesis. 18(1)
We and others have reported an association between raf-1 protein serine/threonine kinase activity and transformation of mammalian cells. Because constitutive tyrosine phosphorylation of specific polypeptides is, in general, indicative of the transfor
Publikováno v:
The cancer journal from Scientific American. 3(1)
Previous studies suggest a central role for Raf-1 protein kinase in mitogenic and radiation damage responsive signaling pathways.Here we report that the expression and enzymatic activity of Raf-1 protein are inhibited in SQ-20B cells exposed to raf a
Publikováno v:
European Journal of Cancer. 48:157
Publikováno v:
Cancer. 71(7)
Renal cell carcinoma (RCC) is a progressive and relatively radioresistant disease. Currently, no data are available on the in vitro radiobiologic characterization of renal tumor cells to the authors' knowledge.Two RCC were cultured from specimens fro
Publikováno v:
Advances in cancer research. 61