Výsledky vyhledávání

Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia

Autor: J. De Vry, Thomas Christoph, Thomas M. Tzschentke, U. Jahnel, Wolfgang P. Schröder, Rolf Terlinden, Ronald J. Tallarida

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 337:312-320

The novel centrally acting analgesic tapentadol [(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride] combines two mechanisms of action, μ-opioid receptor (MOR) agonism and noradrenaline reuptake inhibition (NRI), in a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bfb570504c6772de38ca05fcfd011c
https://doi.org/10.1124/jpet.110.175042

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Tapentadol: mit zwei Mechanismen in einem Molekül wirksam gegen nozizeptive und neuropathische Schmerzen

Autor: Thomas Christoph, U. Jahnel, De Vry J, B.Y. Kögel, Thomas M. Tzschentke, Wolfgang P. Schröder, W. Englberger

Publikováno v: Der Schmerz. 25:19-25

Tapentadol (3-[(1R, 2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl] phenol) is a centrally acting analgesic of a new substance class for the treatment of severe nociceptive and neuropathic pain. Tapentadol combines μ-opioid receptor (MOR) agonism and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc37f1c4c9f6e7f7fa8bc25f379f1466
https://doi.org/10.1007/s00482-010-1004-1

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Comparative Effects of Chlormadinone Acetate and Its 3α- and 3β-Hydroxy Metabolites on Progesterone, Androgen and Glucocorticoid Receptors

Autor: C. Kneip, J. Schneider, U. Jahnel

Publikováno v: Pharmacology. 84:74-81

Aim/Methods: In vitro binding tests to human receptors and in vivo functional activities in animals were used to compare the effects of the progestin chlormadinone acetate (CMA) and its 3α- and 3β-hydroxy metabolites (3α-OH-CMA and 3β-OH-CMA) on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226be47c88b12fcf9b1e9db72eff547b
https://doi.org/10.1159/000226601

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Unterschiedliche Beteiligung opioiderger und noradrenerger Mechanismen an der antinozizeptiven und antiallodynischen Wirksamkeit von Tapentadol in Rattenmodellen nozizeptiver und neuropathischer Schmerzen

Autor: T Christoph, U. Jahnel, Wolfgang P. Schröder, Thomas M. Tzschentke, J de Vrie

Publikováno v: Zeitschrift für Palliativmedizin. 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89e6bee2ac45592d45f1523f6621a3c2
https://doi.org/10.1055/s-0030-1265381

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711 ANTI‐ALLODYNIC ACTIVITY OF TAPENTADOL IN A RAT MODEL OF NEUROPATHIC PAIN DEPENDS ON OPIOID AND NORADRENERGIC, BUT NOT SEROTONERGIC, MECHANISMS

Autor: Thomas M. Tzschentke, U. Jahnel, J. Vry, Thomas Christoph

Publikováno v: European Journal of Pain. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::487facb3449ba0bc4c07576dded30c3b
https://doi.org/10.1016/s1090-3801(09)60714-x

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The antigen self-presentation function of the cytotoxic T-cell clone 10BK.1 depends on reciprocal peptide presentation

Autor: M S, Staege, T, Dick, R, Ertl, U, Jahnel, H, Nawrath, H G, Rammensee, A B, Reske-Kunz

Publikováno v: Immunology. 81(3)

Cells of the cytotoxic T-cell clone 10BK.1 proliferate in response to ovalbumin (OVA) not only in the presence, but also in the absence, of antigen-presenting cells. This response is the consequence of reciprocal antigen presentation by two 10BK.1 ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61b3be7c1a29fc5dbd5048b56f040c16
https://pubmed.ncbi.nlm.nih.gov/8206506

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Class I Antiarrhythmic Drug Effects: What Is the Basis for Subgroups Ia, Ib and Ic in Human Heart Muscle?

Autor: J. Rupp, H. Oelert, P. Satter, U. Jahnel, H. Nawrath

Publikováno v: Cardiac Arrhythmias: The Management of Atrial Fibrillation ISBN: 9783540555889

Thanks to refined electrophysiological techniques, great progress has been made in understanding the cellular mechanisms of cardiac arrhythmias and the action of antiarrhythmic drugs. Nevertheless, the application of clinically useful substances in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8e83147838d534cdb734d3854f4d97c
https://doi.org/10.1007/978-3-662-30492-1_4

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196 TAPENTADOL, A NOVEL CENTRALLY ACTING ANALGESIC: PRECLINICAL EVIDENCE FOR A DUAL MODE OF ACTION UNDERLYING ITS BROAD EFFICACY PROFILE

Autor: T.I.F.H. Cremers, U. Jahnel, Babette-Yvonne Kögel, W. Englberger, J. Vry, Thomas M. Tzschentke, Thomas Christoph, H. H. Hennies, Elmar Friderichs, Klaus Schiene

Publikováno v: European Journal of Pain. 10:S54-S54

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a011d148ae946bc8050d48e94e80d884
https://doi.org/10.1016/s1090-3801(06)60199-7

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[Untitled]

Autor: U. Jahnel, Thomas M. Tzschentke, Thomas I. F. H. Cremers, Hagen-Heinrich Hennies, Thomas Christoph, B. Koegel, W. Englberger, J. De Vry

Publikováno v: The Journal of Pain. 7:S25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1691892648052f62db99a47992e85e03
https://doi.org/10.1016/j.jpain.2006.01.088

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