Zobrazeno 1 - 10
of 171
pro vyhledávání: '"U. Breyer-Pfaff"'
Publikováno v:
British Journal of Clinical Pharmacology. 46:453-459
N-Desmethylclozapine and clozapine N-oxide are major metabolites of the atypical neuroleptic clozapine in humans and undergo renal excretion. The aim of this study was to investigate to what extent the elimination of these metabolites in urine contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8dea2921885d5a26202b13f0da32b
https://doi.org/10.1046/j.1365-2125.1998.00822.x
https://doi.org/10.1046/j.1365-2125.1998.00822.x
Publikováno v:
Neuro-Psychopharmaka Ein Therapie-Handbuch ISBN: 9783211836477
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4ac7f100a651eeb0a754b3a43495d9
https://doi.org/10.1007/978-3-7091-6150-0_8
https://doi.org/10.1007/978-3-7091-6150-0_8
Autor:
U, Breyer-Pfaff, H, Wachsmuth
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(10)
In experiments with expressed human UDP-glucuronosyltransferase 1A4 (UGT1A4), the antipsychotic clozapine proved to be conjugated to two different glucuronides, one of which was identified as the quaternary ammonium glucuronide derivatized at the N-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10562d9952bb886ea3832256b255936c
https://pubmed.ncbi.nlm.nih.gov/11560879
https://pubmed.ncbi.nlm.nih.gov/11560879
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(6)
Biotransformation products of the atypical neuroleptic clozapine were isolated from urine samples of three schizophrenic patients by solid-phase extraction, liquid-liquid extraction for the separation of unpolar and polar metabolites, and thin-layer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::faebbdb759908914b00a70b28fc798a4
https://pubmed.ncbi.nlm.nih.gov/11353764
https://pubmed.ncbi.nlm.nih.gov/11353764
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(8)
Like other basic amphiphilic drugs, the (S)-enantiomer of the antiallergic drug ketotifen exhibited biphasic kinetics when it was converted to two isomeric quaternary ammonium-linked glucuronides in human liver microsomes. For (R)-ketotifen this appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f60d3892c5994b5dc892af6db46db14
https://pubmed.ncbi.nlm.nih.gov/10901693
https://pubmed.ncbi.nlm.nih.gov/10901693
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(11)
The antiallergic drug ketotifen is chiral due to a nonplanar seven-membered ring containing a keto group. Earlier studies have revealed glucuronidation at the tertiary amino group as a major metabolic pathway in humans. Chemical synthesis of glucuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e0cf3952e5e10030ddd85f97a63596d
https://pubmed.ncbi.nlm.nih.gov/10534313
https://pubmed.ncbi.nlm.nih.gov/10534313
Autor:
U, Breyer-Pfaff, K, Nill
Publikováno v:
Advances in experimental medicine and biology. 463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e1337189e25b1c4efafe678d544456a
https://pubmed.ncbi.nlm.nih.gov/10352721
https://pubmed.ncbi.nlm.nih.gov/10352721
Autor:
U. Breyer-Pfaff, D. Fischer
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 22(2)
The H1-antagonist diphenhydramine can undergo direct glucuronidation at its tertiary amino group with formation of a quaternary ammonium glucuronide. The intraindividual variability in the amount of N-glucuronide excretion in urine was investigated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbd2cab855b6420f021e65a2f889202
https://pubmed.ncbi.nlm.nih.gov/9248784
https://pubmed.ncbi.nlm.nih.gov/9248784
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(3)
The tricyclic antidepressant amitriptyline and the H1-receptor antagonist diphenhydramine are conjugated in human liver microsomes fortified with UDP-glucuronic acid at their tertiary amino groups with the formation of quaternary ammonium glucuronide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8e2df4e94a0f0dc1297e1d716d9fefc
https://pubmed.ncbi.nlm.nih.gov/9172952
https://pubmed.ncbi.nlm.nih.gov/9172952
Autor:
K, Foerster, U, Breyer-Pfaff
Publikováno v:
Versicherungsmedizin. 48(2)
In a liability lawsuit an expertise had to answer the question whether a mania in the course of an affective psychosis could have been caused by chronic mercury intoxication resulting from dental amalgam fillings. On the basis of current psychiatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a89b432ee37b5ed05ff1da91cb68096
https://pubmed.ncbi.nlm.nih.gov/8659057
https://pubmed.ncbi.nlm.nih.gov/8659057