Zobrazeno 1 - 10
of 23
pro vyhledávání: '"U. B. Rao Khandavilli"'
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 630-634 (2019)
The investigation of mechanical properties in molecular crystals is emerging as a novel area of interest in crystal engineering. Indeed, good mechanical properties are required to manufacture pharmaceutical and technologically relevant substances int
Externí odkaz:
https://doaj.org/article/f2813ad15e554eff83e37280aa51a1eb
Autor:
U. B. Rao Khandavilli, Leila Keshavarz, Eliška Skořepová, René R. E. Steendam, Patrick J. Frawley
Publikováno v:
Molecules, Vol 25, Iss 8, p 1910 (2020)
The presence of impurities can drastically affect the efficacy and safety of pharmaceutical entities. p-Aminophenol (PAP) is one of the main impurities of paracetamol (PA) that can potentially show toxic effects such as maternal toxicity and nephroto
Externí odkaz:
https://doaj.org/article/ad9d55a6c3df450aa07d20cc3f04a5e4
Autor:
René R. E. Steendam, Mustafa Yousuf, Patrick J. Frawley, Patrick McArdle, Leila Keshavarz, Barbara E. Schaller, U. B. Rao Khandavilli
Publikováno v:
CrystEngComm. 22:412-415
Pregabalin is an anti-convulsant blockbuster chiral drug with the trade name Lyrica in its S-form. Anhydrous pregabalin (SPG) is brittle in nature and herein, we report two novel plastically bendable SPG salts with pharmaceutically acceptable coforme
Publikováno v:
Crystal Growth & Design. 19:4483-4488
Understanding the link between solution chemistry and nucleation is essential to control crystallization processes, in particular regarding pharmaceutical compounds. In the present work, the link between the solution hydration state and crystallizati
Autor:
René R. E. Steendam, Patrick J. Frawley, Eliška Skořepová, U. B. Rao Khandavilli, Leila Keshavarz
Publikováno v:
Molecules
Volume 25
Issue 8
Molecules, Vol 25, Iss 1910, p 1910 (2020)
Volume 25
Issue 8
Molecules, Vol 25, Iss 1910, p 1910 (2020)
The presence of impurities can drastically affect the efficacy and safety of pharmaceutical entities. p-Aminophenol (PAP) is one of the main impurities of paracetamol (PA) that can potentially show toxic effects such as maternal toxicity and nephroto
Autor:
Nuala M. Maguire, Anita R. Maguire, Simon E. Lawrence, Balakrishna R. Bhogala, U. B. Rao Khandavilli, Abhijeet S. Sinha, Eliška Skořepová
Publikováno v:
Crystal Growth & Design. 18:4571-4577
Cocrystallization studies on Naringenin with 27 coformers have led to the formation of five new solid forms: a piperazinium salt (PIP+-NR-) and four cocrystals with the coformers flavone (FLV), 4-hydroxypyridine (4-HP), anthranilamide (ATA), and 4,4
Publikováno v:
Crystal Growth & Design. 18:3549-3557
In the solid state (±)-3-methyl-2-phenylbutyramide 1 spontaneously resolves into a conglomerate (Form I) that crystallizes in a racemic form (Form II) upon evaporation from the melt, a rarely reported phenomenon. An additional racemic polymorph, For
Autor:
Simon E. Lawrence, Aoife Foley, Declan P. Gavin, Thomas S. Moody, Pat O'Neill, U. B. Rao Khandavilli, Anita R. Maguire
Publikováno v:
Tetrahedron: Asymmetry. 28:577-585
Hydrolase-catalysed dynamic kinetic resolutions of chroman-2-ol and 3-methyl chroman-2-ol can be effected with up to 88% conversion and 92% ee through the use of organic solvents. Extension to the resolution of the tolterodine precursor 1 proved more
Autor:
Simon E. Lawrence, Lorraine M. Bateman, Eoin Ó Muimhneacháin, U. B. Rao Khandavilli, Leticia M. Pardo, Gerard P. McGlacken
Publikováno v:
Advanced Synthesis & Catalysis. 359:1529-1534
A synthesis of tricyclic oxoisochromene derivatives via an intramolecular direct arylation of cycloalkyl-1,3-diketone-derived α,β-unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migr
Publikováno v:
CrystEngComm. 19:918-929
Novel salts of glibenclamide (GBA), namely glibenclamide-sodium (GBA-Na), glibenclamide-potassium (GBA-K) and glibenclamide-ammonium (GBA-NH4) were crystallized under different conditions to obtain their polymorphs, and their aqueous solubility and h