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Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses

Autor: U Wang Lei, Abrey J. Yeo, Keerat Junday, Ashmitha Sundarrajan, Michelle Pewarchuk, Hannah C Leeson, Amanda W. Kijas, Ernst J. Wolvetang, Sarah L. Withey, Dmitry A. Ovchinnikov, Martin F. Lavin

Publikováno v: Human Molecular Genetics. 29:990-1001

Patients with ataxia-telangiectasia (A-T) lack a functional ATM kinase protein and exhibit defective repair of DNA double-stranded breaks and response to oxidative stress. We show that CRISPR/Cas9-assisted gene correction combined with piggyBac (PB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4be0a21c534d1c7e2c36bc1c00b09a
https://doi.org/10.1093/hmg/ddaa023

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Advances of the skin microbiopsy for blood and skin sampling with streamlined handling and fabrication settings

Autor: U Wang Lei

Conventional skin biopsy is reported to limit clinical research due to its invasiveness. Here we describe an absorbent microneedle-based device, the absorbent microbiopsy, for simple and minimally invasive sampling of skin and blood mixture. The goal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9715bed8cdd33fefb520eeb5c1606f08
https://doi.org/10.14264/uql.2020.168

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