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Autor: M. C. Houwertjes, T. M. Beaufort, U. W. Kleef, J. M. K. H. Wierda, K. Kuizenga, Johannes H. Proost

Publikováno v: Journal of Pharmacokinetics and Biopharmaceutics. 27:173-190

In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore, investigators have to extrapolate the plasma concentration to Time 0. Extrapolation, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9eb2255c3ab6fc16534d77a78f1b3cd
https://doi.org/10.1023/a:1020653922866

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Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487

Autor: A. M. Beaufort, Sandor Agoston, N. J. Smeulers, Jmkh Wierda, U. W. Kleef

Publikováno v: Canadian Journal of Anaesthesia. 41:213-220

Three muscle relaxants, Org 9453, Org 9489 and Org 9487, short-acting in animals, were investigated to establish their profiles in humans. Potency, time course of action, and pharmacokinetic behaviour were studied in 90 healthy patients during fentan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f24f1e0902681c9990d6243335f5a62
https://doi.org/10.1007/bf03009833

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The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl

Autor: L. M. Lambalk, Jmkh Wierda, U. W. Kleef, Wybe D. Kloppenburg, Sandor Agoston

Publikováno v: Canadian journal of anaesthesia-Journal canadien d anesthesie, 38(4), 430-435. SPRINGER

The pharmacodynamics and pharmacokinetics of a new non-depolarizing neuromuscular blocking agent, Org 9426, were investigated. Ten patients undergoing elective head and neck surgery and anaesthetized with nitrous oxide, halothane and fentanyl, receiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e763459498322fac7b5e5d3eaf040710
https://hdl.handle.net/11370/618a5399-153f-46cc-8dcc-fc85c454be9b

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Do plasma concentrations obtained from early arterial blood sampling improve pharmacokinetic/pharmacodynamic modeling?

Autor: T M, Beaufort, J H, Proost, K, Kuizenga, M C, Houwertjes, U W, Kleef, J M, Wierda

Publikováno v: Journal of pharmacokinetics and biopharmaceutics. 27(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f05306a2d1e12e540aae215a6a36372
https://pubmed.ncbi.nlm.nih.gov/10567954

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The influence of hypothermia (surface cooling) on the time-course of action and on the pharmacokinetics of rocuronium in humans

Autor: A M, Beaufort, J M, Wierda, M, Belopavlovic, P J, Nederveen, U W, Kleef, S, Agoston

Publikováno v: European journal of anaesthesiology. Supplement. 11

Hypothermia prolongs the time-course of action of non-depolarizing neuromuscular blocking agents. The mechanism, however, is unknown. We studied the influence of hypothermia (by surface cooling, nasopharyngeal temperatureor = 31 degrees C) on the tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31b08208fdc963f500335688d9101adf
https://pubmed.ncbi.nlm.nih.gov/8557016

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Pharmacokinetics and pharmacodynamics of pipecuronium in patients with cirrhosis

Autor: G, D'Honneur, M, Khalil, C, Dominique, J P, Haberer, U W, Kleef, P, Duvaldestin

Publikováno v: Anesthesia and analgesia. 77(6)

To determine the effect of liver cirrhosis on the pharmacokinetics and pharmacodynamics of pipecuronium, the authors administered 100 micrograms/kg of pipecuronium intravenously to eight patients with liver cirrhosis and eight patients with normal li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b4596c26371d19e3ba642891811da1e
https://pubmed.ncbi.nlm.nih.gov/8250313

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The pharmacokinetics, urinary and biliary excretion of pipecuronium bromide

Autor: J M, Wierda, J, Szenohradszky, A P, De Wit, G, Zentai, S, Agoston, M, Kakas, U W, Kleef, D K, Meijer

Publikováno v: European journal of anaesthesiology. 8(6)

The pharmacodynamics and -kinetics of pipecuronium were studied in 12 patients, six of whom received 100 micrograms kg-1 for laryngectomy (Group L), and six who underwent choledochotomy after insertion of the T-drain and were given 50 micrograms kg-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::852c69fd326207246803a28dde606cb9
https://pubmed.ncbi.nlm.nih.gov/1662599

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5β-PREGNAN-3α-OL-20-ONE IN URINE

Autor: H. J. van der Molen, U. W. Kleef

Publikováno v: Acta Endocrinologica. 41:247-258

The occurrence, metabolic formation and degradation of 5β-pregnan-3α-ol-20-one are reviewed. Estimation of 5β-pregnan-3α-ol-20-one in urine has shown that: under acid conditions 5β-pregnane-3α,17α,20α-triol is destroyed with partial formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d83f7d0eea41e11067c5ae8d71d4526c
https://doi.org/10.1530/acta.0.0410247

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