Zobrazeno 1 - 10
of 359
pro vyhledávání: '"U Storb"'
Publikováno v:
The Journal of Immunology. 157:4458-4463
Previous experiments have suggested an important role for the Ig enhancers and transcription in targeting somatic hypermutation. To determine whether the requirement of the enhancers is Ig chain specific, we analyzed two lambda 2 light chain transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8141e94bb9a2670f4579c4c9a5c5a818
https://doi.org/10.4049/jimmunol.157.10.4458
https://doi.org/10.4049/jimmunol.157.10.4458
Publikováno v:
The Journal of Immunology. 147:2354-2358
A strong transcriptional enhancer was identified for the human lambda L chain Ig gene complex. Enhancer activity was measured by activation of the chloramphenicol acetyl transferase (CAT) gene in a transient assay using both mouse and human B lymphoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ee835f1bfeebb46698b4f00503c47d
https://doi.org/10.4049/jimmunol.147.7.2354
https://doi.org/10.4049/jimmunol.147.7.2354
Publikováno v:
The Journal of Immunology. 146:2826-2835
A rearrangement test gene, pHRD, containing the mouse IgH enhancer and the metallothionein promoter, has previously been shown to rearrange efficiently after transfection into a pre-B cell line. Experiments are now reported that assess the requiremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cd1c5885aa2c3a37e140dd4e7545a7d
https://doi.org/10.4049/jimmunol.146.8.2826
https://doi.org/10.4049/jimmunol.146.8.2826
Publikováno v:
The Journal of Immunology. 144:4857-4862
A cDNA clone was isolated from a mouse pre-B cell line, the sequence of which has a very high homology with rat and human thymosin beta 4 genes. However, the mouse clone has an insertion of 98 bp relative to the published rat and human sequences upst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96fb2ef9a431618695f430032cb792a3
https://doi.org/10.4049/jimmunol.144.12.4857
https://doi.org/10.4049/jimmunol.144.12.4857
Autor:
U, Storb, A, Peters, E, Klotz, N, Kim, H M, Shen, J, Hackett, B, Rogerson, R, O'Brien, T E, Martin
Publikováno v:
The International journal of developmental biology. 42(7)
This review describes studies on somatic hypermutation of immunoglobulin genes that were started in the mid-80s in collaboration with Ralph Brinster. Almost all of the experiments were carried out using Ig transgenes as targets for the somatic mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb202b8ede151e49853211dab9fe464f
https://pubmed.ncbi.nlm.nih.gov/9853828
https://pubmed.ncbi.nlm.nih.gov/9853828
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(2)
We have characterized a novel substrate for somatic hypermutation, confirming that non-Ig sequences can be targeted for mutation and demonstrating that this substrate allows for the rapid assay for mutations. An artificial sequence containing alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a8750482aa1372c9a671d6c8032c92b
https://pubmed.ncbi.nlm.nih.gov/9670955
https://pubmed.ncbi.nlm.nih.gov/9670955
Publikováno v:
Current topics in microbiology and immunology. 229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17da974dbedc030d11a376dba84c2aca
https://pubmed.ncbi.nlm.nih.gov/9479844
https://pubmed.ncbi.nlm.nih.gov/9479844
Publikováno v:
The Journal of Experimental Medicine
gamma 2b transgenic mice have a severe B cell defect, apparently caused by strong feedback inhibition of endogenous H-gene rearrangement coupled with an inability of gamma 2b to provide the survival/maturation functions of mu. A unique gamma 2b trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31cbd2ebc0dc1903c7f2354cf379dbc7
https://pubmed.ncbi.nlm.nih.gov/7869028
https://pubmed.ncbi.nlm.nih.gov/7869028
Autor:
U, Storb, P, Engler, E, Klotz, A, Weng, D, Haasch, C, Pinkert, L, Doglio, M, Glymour, R, Brinster
Publikováno v:
Current topics in microbiology and immunology. 182
Transgenic mice are discussed which carry a rearrangement test transgene. The methylation status of the transgene varies, depending on the background mouse strain. When the transgene is bred into the C57BL/6 strain, it is completely methylated and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6444d373078f8d7d1ba6fa590d97114
https://pubmed.ncbi.nlm.nih.gov/1490348
https://pubmed.ncbi.nlm.nih.gov/1490348
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 146(9)
Experiments with transgenic mice carrying rearranged Ig transgenes have shown that membrane bound Ig molecules cause feedback inhibition of endogenous Ig gene rearrangement. However, this inhibition is never complete. It has been postulated that esca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8ffbf9560cec53c885c71488c8c2959
https://pubmed.ncbi.nlm.nih.gov/2016544
https://pubmed.ncbi.nlm.nih.gov/2016544