Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host

Autor: S. Ribes, L. Zacke, S. Nessler, N. Saiepour, E. Avendaño-Guzmán, M. Ballüer, U. K. Hanisch, R. Nau

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)

Abstract Background Bacterial meningitis is a fatal disease with a mortality up to 30% and neurological sequelae in one fourth of survivors. Available vaccines do not fully protect against this lethal disease. Here, we report the protective effect of

Externí odkaz: https://doaj.org/article/48bd525594714007bb2206482d10b752

Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice.

Autor: Wei, Wei^1,2 (AUTHOR), Lattau, Seyed Siyawasch Justus¹ (AUTHOR), Xin, Wenqiang¹ (AUTHOR), Pan, Yongli¹ (AUTHOR), Tatenhorst, Lars¹ (AUTHOR), Zhang, Lin¹ (AUTHOR), Graf, Irina¹ (AUTHOR), Kuang, Yaoyun¹ (AUTHOR), Zheng, Xuan¹ (AUTHOR), Hao, Zhongnan¹ (AUTHOR), Popa‐Wagner, Aurel³ (AUTHOR), Gerner, Stefan T.⁴ (AUTHOR), Huber, Sabine⁴ (AUTHOR), Nietert, Manuel⁵ (AUTHOR), Klose, Christian⁶ (AUTHOR), Kilic, Ertugrul⁷ (AUTHOR), Hermann, Dirk M.³ (AUTHOR), Bähr, Mathias¹ (AUTHOR), Huttner, Hagen B.⁴ (AUTHOR), Liu, Hua² (AUTHOR)

Publikováno v: Advanced Science. 11/6/2024, Vol. 11 Issue 41, p1-20. 20p.

Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation

Autor: Satyabrata Kar, Sylvain Doré, D. Seto, Rémi Quirion, U.-K. Hanisch

Publikováno v: Proceedings of the National Academy of Sciences. 94:14054-14059

Insulin-like growth factors-I and -II (IGF-I and -II) are structurally related mitogenic polypeptides with potent growth promoting effects. These peptides and their corresponding IGF-I and -II receptors are selectively localized in the brain. To date

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5869e546182c27f323d94db83f57a148
https://doi.org/10.1073/pnas.94.25.14054

Microglia Properties

Autor: U.-K. Hanisch, D. van Rossum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc09c352312613cc64e054acf83e624b
https://doi.org/10.1016/b978-008045046-9.01013-5

Biochemical analysis of proteasomes from mouse microglia: induction of immunoproteasomes by interferon-gamma and lipopolysaccharide

Autor: R, Stohwasser, J, Giesebrecht, R, Kraft, E C, Müller, K G, Häusler, H, Kettenmann, U K, Hanisch, P M, Kloetzel

Publikováno v: Glia. 29(4)

The 20S proteasome is a multicatalytic threonine protease and serves to process peptides that are subsequently presented as antigenic epitopes by MHC class I molecules. In the brain, microglial cells are the major antigen presenting cells and they re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e050ee96e7c75b4f96eb1f0ac332878
https://pubmed.ncbi.nlm.nih.gov/10652445