Zobrazeno 1 - 10
of 199
pro vyhledávání: '"U Helena, Danielson"'
Autor:
Daniela Cederfelt, Dilip Badgujar, Ayan Au Musse, Bernhard Lohkamp, U. Helena Danielson, Doreen Dobritzsch
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1763 (2023)
The activity of β-ureidopropionase, which catalyses the last step in the degradation of uracil, thymine, and analogous antimetabolites, is cooperatively regulated by the substrate and product of the reaction. This involves shifts in the equilibrium
Externí odkaz:
https://doaj.org/article/b1ca3c457cbe4892b9e70fd103dea448
Autor:
Mostafa Fekry, Khyati K. Dave, Dilip Badgujar, Emil Hamnevik, Oskar Aurelius, Doreen Dobritzsch, U. Helena Danielson
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1360 (2023)
Tyrosinases belong to the type-III copper enzyme family, which is involved in melanin production in a wide range of organisms. Despite similar overall characteristics and functions, their structures, activities, substrate specificities and regulation
Externí odkaz:
https://doaj.org/article/62941f7a897a42679d655a7346dc81f4
Autor:
Jie Yang, Vladimir O. Talibov, Stefan Peintner, Claire Rhee, Vasanthanathan Poongavanam, Matthis Geitmann, Matteo Rossi Sebastiano, Bernd Simon, Janosch Hennig, Doreen Dobritzsch, U. Helena Danielson, Jan Kihlberg
Publikováno v:
ACS Omega, Vol 5, Iss 8, Pp 3979-3995 (2020)
Externí odkaz:
https://doaj.org/article/49645015752a4b7e83c6cc6080b839b7
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced hepatocellular carci
Externí odkaz:
https://doaj.org/article/55b8ebab05a845dda7c6c094c3087697
Autor:
Rasel Al-Amin, Lars Johansson, Eldar Abdurakhmanov, Nils Landegren, Liza Löf, Linda Arngården, Andries Blokzijl, Richard Svensson, Maria Hammond, Peter Lönn, Johannes Haybaeck, Masood Kamali-Moghaddam, Annika Jensen, U Helena Danielson, Per Artursson, Thomas Lundbäck, Ulf Landegren
Publikováno v:
Nucleic acids research. 50(22)
Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolution is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79adb2953b2ab6b08676aeb2f8a0724f
https://pubmed.ncbi.nlm.nih.gov/36189884
https://pubmed.ncbi.nlm.nih.gov/36189884
Autor:
Rasel A. Al-Amin, Phathutshedzo M. Muthelo, Eldar Abdurakhmanov, Cécile Vincke, Shahnaz P. Amin, Serge Muyldermans, U. Helena Danielson, Ulf Landegren
Publikováno v:
Analytical chemistry. 94(28)
High-quality affinity probes are critical for sensitive and specific protein detection, in particular for detection of protein biomarkers in the early phases of disease development. Proximity extension assays (PEAs) have been used for high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc76fafe80fffec7eeaba9dd4f304557
https://pubmed.ncbi.nlm.nih.gov/35786874
https://pubmed.ncbi.nlm.nih.gov/35786874
Autor:
Doreen Dobritzsch, Daniela Cederfeldt, Daniele Tedesco, Martin J. Talu, Alberto Del Rio, Xavier Barril, Marina Naldi, Giovanna Forte, Paola Sanese, Edoardo Fabini, Vladimir O. Talibov, Elisabetta Manoni, Martina Lepore Signorile, Manuela Bartolini, Moira Rachman, Edward A. FitzGerald, U. Helena Danielson, Cristiano Simone, Filip Mihalic
Publikováno v:
ChemBioChem (Internet) 22 (2021). doi:10.1002/cbic.202000736
info:cnr-pdr/source/autori:Talibov, Vladimir O.; Fabini, Edoardo; FitzGerald, Edward A.; Tedesco, Daniele; Cederfeldt, Daniela; Talu, Martin J.; Rachman, Moira M.; Mihalic, Filip; Manoni, Elisabetta; Naldi, Marina; Sanese, Paola; Forte, Giovanna; Lepore Signorile, Martina; Barril, Xavier; Simone, Cristiano; Bartolini, Manuela; Dobritzsch, Doreen; Del Rio, Alberto; Danielson, U. Helena/titolo:Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase/doi:10.1002%2Fcbic.202000736/rivista:ChemBioChem (Internet)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
'ChemBioChem ', vol: 22, pages: 1597-1608 (2021)
Chembiochem
info:cnr-pdr/source/autori:Talibov, Vladimir O.; Fabini, Edoardo; FitzGerald, Edward A.; Tedesco, Daniele; Cederfeldt, Daniela; Talu, Martin J.; Rachman, Moira M.; Mihalic, Filip; Manoni, Elisabetta; Naldi, Marina; Sanese, Paola; Forte, Giovanna; Lepore Signorile, Martina; Barril, Xavier; Simone, Cristiano; Bartolini, Manuela; Dobritzsch, Doreen; Del Rio, Alberto; Danielson, U. Helena/titolo:Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase/doi:10.1002%2Fcbic.202000736/rivista:ChemBioChem (Internet)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
'ChemBioChem ', vol: 22, pages: 1597-1608 (2021)
Chembiochem
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4a6e19b0c90178582e337d6fd34b9f
https://doi.org/10.1002/cbic.202000736
https://doi.org/10.1002/cbic.202000736
Publikováno v:
Marine Drugs, Vol 11, Iss 11, Pp 4279-4293 (2013)
The screening of extracts from marine organisms is a widely used strategy to discover new drug leads. A common problem in the screening process is the generation of false positive hits through unspecific effects from the complex chemical composition
Externí odkaz:
https://doaj.org/article/d29205b896b34901b6f23ab1c976bcfc
Autor:
U. Helena Danielson, Helena Nordström, Tom Dzus, Valeria Napolitano, Giulia Opassi, Gerhard Klebe, Arne Lundin, Francesca Magari
Publikováno v:
Protein Science
Protein Science : A Publication of the Protein Society
Protein Science : A Publication of the Protein Society
Procedures for producing and exploring Trypanosoma cruzi farnesyl pyrophosphate synthase (tcFPPS) for surface plasmon resonance (SPR) biosensor‐driven fragment‐based discovery have been established. The method requires functional sensor surfaces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4244925221396853671363436167464e
https://doi.org/10.1002/pro.3834
https://doi.org/10.1002/pro.3834
Autor:
Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O. Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J. Craig, Yoseph Atilaw, Anja Sandström, Lindon W. K. Moodie, Åke Lundkvist, Martijn J. van Hemert, Johan Neyts, Johan Lennerstrand, Jan Kihlberg, Kristian Sandberg, U. Helena Danielson, Jens Carlsson
Publikováno v:
Journal of the American Chemical Society, 144(7), 2905-2920. AMER CHEMICAL SOC
Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946c3c3e10aa0c690988b970c049d161
http://hdl.handle.net/1887/3479854
http://hdl.handle.net/1887/3479854
