Zobrazeno 1 - 10
of 15
pro vyhledávání: '"U A Germann"'
Publikováno v:
Current Genetics. 19:375-381
Rapidly growing cultures of N. crassa do not produce laccase. Exposure of this fungus to different inducing agents leads to a de novo biosynthesis of extracellular laccase in vegetative cultures. In this study the induction of laccase after addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d82c877be37fdc0b1613e3b16355d3
https://doi.org/10.1007/bf00309598
https://doi.org/10.1007/bf00309598
Autor:
U A, Germann, T C, Chambers
Publikováno v:
Cytotechnology. 27(1-3)
Inherent or acquired resistance of tumor cells to cytotoxic drugs represents a major limitation to the successful chemotherapeutic treatment of cancer. During the past three decades dramatic progress has been made in the understanding of the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a120518b2b78b9a4eed58e83bb962d13
https://pubmed.ncbi.nlm.nih.gov/19002782
https://pubmed.ncbi.nlm.nih.gov/19002782
Publikováno v:
Current medicinal chemistry. 6(9)
p38 MAP kinase is a member of the family of kinases which mediate intracellular transduction pathways. The activation of this particular MAP kinase pathway is in response to a broad variety of extracellular stimuli. Subsequent downstream events trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cf7ee3406ff5ec078c97e52789f4567
https://pubmed.ncbi.nlm.nih.gov/10495353
https://pubmed.ncbi.nlm.nih.gov/10495353
Autor:
U A, Germann
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a98e7815177d0154eacad947172bfabd
https://pubmed.ncbi.nlm.nih.gov/9113648
https://pubmed.ncbi.nlm.nih.gov/9113648
Publikováno v:
Cytokines and molecular therapy. 2(1)
Gene fusions can be employed to ensure concomitant expression of two different proteins under the same transcriptional control elements. We have synthesized a retroviral expression vector (pHaMG1) containing a human multidrug resistance (MDR1)-glucoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::314e96899dd1998b1ac61e5ffae0faa4
https://pubmed.ncbi.nlm.nih.gov/9384689
https://pubmed.ncbi.nlm.nih.gov/9384689
Publikováno v:
Genes, chromosomescancer. 10(4)
The physiologic expression of the human multidrug resistance MDR1 gene product P-glycoprotein is controlled in a tissue- and cell-specific manner, but the regulatory mechanisms have not been characterized in great detail. Studies by Kohno et al. [(19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::652ebe86da2ddbdb50a3d460c28ebc1d
https://pubmed.ncbi.nlm.nih.gov/7522541
https://pubmed.ncbi.nlm.nih.gov/7522541
Publikováno v:
The Journal of biological chemistry. 267(7)
Drug-resistant tumor cells actively extrude a variety of chemotherapeutic agents by the action of the multi-drug resistance (MDR1) gene product, the plasma membrane P-glycoprotein. In this report we show that the expression of the human MDR1 gene in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92a7ce2c7ebdfacbe3e59889af12c08f
https://pubmed.ncbi.nlm.nih.gov/1347044
https://pubmed.ncbi.nlm.nih.gov/1347044
Autor:
U A Germann, Konrad Lerch
Publikováno v:
Biochemical Journal. 245:479-484
The copper-uptake process in the cell-wall-deficient slime variant of the fungus Neurospora crassa was compared with that in a wild-type strain. In both organisms investigated most of the copper is taken up from the culture medium during the exponent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b584b3d6445898d7997d3928bfc8c8a3
https://doi.org/10.1042/bj2450479
https://doi.org/10.1042/bj2450479
Publikováno v:
The Journal of biological chemistry. 263(2)
The complete structures of the laccase genes isolated from two different Neurospora crassa wild-type strains are described. The genes were cloned by screening partial genomic DNA libraries with a nick-translated laccase-specified 1.36-kilobase SalI f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64eac67f89c0715d60565ca54b781af1
https://pubmed.ncbi.nlm.nih.gov/2961749
https://pubmed.ncbi.nlm.nih.gov/2961749
Publikováno v:
The Journal of biological chemistry. 264(13)
A novel fusion gene has been created in which the expression of a dominant selectable marker, the human multidrug resistance gene, is directly linked to the expression of human adenosine deaminase cDNA. The chimeric gene was inserted between the long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4fa5235fa5fe858060341951c83a163
https://pubmed.ncbi.nlm.nih.gov/2565338
https://pubmed.ncbi.nlm.nih.gov/2565338