Zobrazeno 1 - 10 of 110 pro vyhledávání: '"U, Regenass"'
1
Indole Alkaloids within vitroAntiproliferative Activity from the Ammoniacal Extract ofNauclea orientalis1
Autor: C. A. J. Erdelmeier, Otto Sticher, U. Regenass, Topul Rali
Publikováno v: Planta Medica. 58:43-48
Nine angustine-type alkaloids were isolated from ammoniacal extracts of Nauclea orientalis L. (Rubiaceae). Three of them, 10-hydroxyangustine and the two diastereoisomeric 3,14-dihydroangustolines, have not been described in the literature thus far.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::368a1f830375e15197643cb04c2a3d08
https://doi.org/10.1055/s-2006-961387
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2
Sequence specific antisense oligonucleotide analog interference with spermidine/spermine N1-acetyltransferase gene expression
Autor: M, Fogel-Petrovic, S, Vujcic, R, Häner, U, Regenass, H, Mett, C W, Porter
Publikováno v: Anticancer research. 16(5A)
Induction of the polyamine acetylating enzyme, spermidine/spermine N1-acetyltransferase (SSAT), is one of several biochemical effects associated with the antiproliferative action of polyamine analogs such as N1, N11 diethylnorspermine (DENSPM). Findi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bcf6486b19f04c0a39d3fb0c164304b
https://pubmed.ncbi.nlm.nih.gov/8917345
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3
4,5-bis(4-fluoroanilino)phthalimide: A selective inhibitor of the epidermal growth factor receptor signal transduction pathway with potent in vivo antitumor activity
Autor: E, Buchdunger, H, Mett, U, Trinks, U, Regenass, M, Müller, T, Meyer, P, Beilstein, B, Wirz, P, Schneider, P, Traxler
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 1(8)
Deregulated signal transduction via the epidermal growth factor (EGF) receptor family of tyrosine protein kinase growth factor receptors is associated with proliferative diseases such as cancer and psoriasis. In an attempt to selectively block signal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9f8edbee9857254cd5db359729ad966
https://pubmed.ncbi.nlm.nih.gov/9816050
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4
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity
Autor: U, Regenass, H, Mett, J, Stanek, M, Mueller, D, Kramer, C W, Porter
Publikováno v: Cancer research. 54(12)
Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been shown to have significant antitumor activity in several human solid tumor systems (U. Regena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0be310ba2ab029d6a0fd478e2f2a10da
https://pubmed.ncbi.nlm.nih.gov/8205541
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5
Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251
Autor: E, Andrejauskas-Buchdunger, U, Regenass
Publikováno v: Cancer research. 52(19)
The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dd22affeb2c6bc9c635d437deb9d20d
https://pubmed.ncbi.nlm.nih.gov/1394140
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6
New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity
Autor: U, Regenass, G, Caravatti, H, Mett, J, Stanek, P, Schneider, M, Müller, A, Matter, P, Vertino, C W, Porter
Publikováno v: Cancer research. 52(17)
Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57b0cce2f6151d15499b73e2b26894f6
https://pubmed.ncbi.nlm.nih.gov/1511437
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7
Indole alkaloids with in vitro antiproliferative activity from the ammoniacal extract of Nauclea orientalis
Autor: C A, Erdelmeier, U, Regenass, T, Rali, O, Sticher
Publikováno v: Planta medica. 58(1)
Nine angustine-type alkaloids were isolated from ammoniacal extracts of Nauclea orientalis L. (Rubiaceae). Three of them, 10-hydroxyangustine and the two diastereoisomeric 3,14-dihydroangustolines, have not been described in the literature thus far.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::354c16f2bc2742f854de3648c3f9e242
https://pubmed.ncbi.nlm.nih.gov/1620742
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9
Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors
Autor: J F, Geissler, P, Traxler, U, Regenass, B J, Murray, J L, Roesel, T, Meyer, E, McGlynn, A, Storni, N B, Lydon
Publikováno v: The Journal of biological chemistry. 265(36)
Various derivatives of thiazolidine-diones have been identified as tyrosine protein kinase inhibitors. The epidermal growth factor (EGF) receptor kinase and c-src kinase were inhibited in vitro with IC50 values in the range of 1-7 microM. The v-abl t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91d1c038a37017741b55ad199ef96b8c
https://pubmed.ncbi.nlm.nih.gov/2176210
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