Zobrazeno 1 - 10
of 129
pro vyhledávání: '"U, Prabhakar"'
Autor:
U. Prabhakar, R. Vora, M. Nakada, M. DeWitte, R. E. Corringham, C. Sturgeon, Duncan I. Jodrell, S. A. Hoare, Ewan Brown, John F. Smyth, David Propper, Frances R. Balkwill, Rhona Aird, Kellie A. Charles, R. L. Rye
Publikováno v:
Annals of Oncology. 19:1340-1346
Background Tumour necrosis factor-α (TNF-α) is an important regulator of the chronic inflammation contributing to tumour progression. Infliximab, an anti-TNF-α monoclonal antibody was investigated in this trial of patients with advanced cancer. Th
Publikováno v:
Drug Safety. 31:885-960
Publikováno v:
Molecular and Cellular Biochemistry. 197:53-59
Neutral endopeptidase (NEP, 24.11) is an ectoenzyme involved in the degradation of peptide hormones such as endothelin (ET), atrial natriuretic factor and enkephalins. The current study was designed to assess the involvement of NEP in ischemia-induce
Publikováno v:
International Journal of Immunopharmacology. 17:221-224
We examined the effects of adenosine A 1 and A 2 receptor agonists on LPS-stimulated TNFα production by human monocytes isolated from peripheral blood. We have demonstrated that CGS-21680, a highly selective A 2 agonist inhibited production of TNFα
Autor:
U. Prabhakar, Nicholas D. James, Robert E. Hawkins, X. Qin, JF Rossi, Peter F.A. Mulders, H. Davis, B. Berns, Ivo Kocák, S. Négrier
Publikováno v:
British Journal of Cancer, 103, 1154-62
British Journal of Cancer, 103, 8, pp. 1154-62
British Journal of Cancer, 103, 8, pp. 1154-62
Item does not contain fulltext BACKGROUND: Serum interleukin (IL)-6 levels correlate with disease outcomes in renal cell carcinoma (RCC) patients. Siltuximab, a chimeric, murine-human mAb against IL-6, was evaluated in a three-part phase I/II study i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ba6d2277dc239096ac215b957829af
http://hdl.handle.net/2066/87631
http://hdl.handle.net/2066/87631
Autor:
B. Sleight, Greg Yanik, Alan S. Gamis, Shalini Shenoy, John E. Levine, Thomas Braun, Ann E. Haight, Kirk R. Schultz, R. Vora, U. Prabhakar
Publikováno v:
Biology of Blood and Marrow Transplantation. 12(2)
Akademický článek
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Publikováno v:
Biochemical and Biophysical Research Communications. 241:212-214
In this study, the involvement of osteopontin in a rat model of ischemia-induced acute renal failure (ARF) was evaluated. In unilaterally nephrectomized Sprague Dawley rats where the left artery was occluded for 30 min., plasma creatinine levels incr
Publikováno v:
Agents and Actions. 39:C64-C66
Exposure of human monocytes (HM) to E. coli lipopolysaccharide (LPS) results in measurable production of both IL-1 beta and TNF alpha in culture supernatants. It has previously been reported that the elevation of cAMP levels in HM selectively suppres
Publikováno v:
Molecular and cellular biochemistry. 197(1-2)
Neutral endopeptidase (NEP, 24.11) is an ectoenzyme involved in the degradation of peptide hormones such as endothelin (ET), atrial natriuretic factor and enkephalins. The current study was designed to assess the involvement of NEP in ischemia-induce