Zobrazeno 1 - 10
of 550
pro vyhledávání: '"U, Hübscher"'
Publikováno v:
Journal of Biological Chemistry. 268:15070-15079
We have purified a high molecular weight complex (RC-1) from calf thymus nuclei that catalyzes a recombinational repair of double-strand gaps and deletions in DNA by gene conversion as well as cross-over events leading to cointegrant products. These
Publikováno v:
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)). 72(12)
The aim of this study was to investigate which meaning is attributed to health by the general population. Furthermore, the relationship between health satisfaction and health importance was also analysed.A sample of 4,808 representatively selected su
Publikováno v:
Journal of Virology. 65:3175-3184
DNA amplification of the helper-dependent parvovirus AAV (adeno-associated virus) can be induced by a variety of genotoxic agents in the absence of coinfecting helper virus. Here we investigated whether the origin of AAV type 2 DNA replication cloned
Autor:
U, Hübscher, Y S, Seo
Publikováno v:
Molecules and cells. 12(2)
DNA replication is one of the most important events in living cells, and it is still a key problem how the DNA replication machinery works in its details. A replication fork has to be a very dynamic apparatus since frequent DNA polymerase switches fr
Publikováno v:
Progress in nucleic acid research and molecular biology. 65
In eukaryotic cells, DNA transactions such as replication, repair, and transcription require a large set of proteins. In all of these events, complexes of more than 30 polypetides appear to function in highly organized and structurally well-defined m
Autor:
D, Georlette, Z O, Jónsson, F, Van Petegem, J, Chessa, J, Van Beeumen, U, Hübscher, C, Gerday
Publikováno v:
European journal of biochemistry. 267(12)
The cloning, overexpression and characterization of a cold-adapted DNA ligase from the Antarctic sea water bacterium Pseudoalteromonas haloplanktis are described. Protein sequence analysis revealed that the cold-adapted Ph DNA ligase shows a signific
Publikováno v:
The Journal of biological chemistry. 274(47)
Among the different base excision repair pathways known, the long patch base excision repair of apurinic/apyrimidinic sites is an important mechanism that requires proliferating cell nuclear antigen. We have reconstituted this pathway using purified
Publikováno v:
Journal of molecular biology. 285(1)
Proliferating cell nuclear antigen can interact with DNA polymerase epsilon on linear DNA templates, even in the absence of other auxiliary factors (replication factor C, replication protein A), and thereby stimulate its primer recognition and DNA sy
Autor:
U, Hübscher
Publikováno v:
Schweizerische medizinische Wochenschrift. 128(35)
The maintenance of genetic information in a cell is ensured by essential macromolecular events called DNA replication and DNA repair. The cell possesses many control mechanisms that allow the optimal strategy under extreme physiological conditions. A
Publikováno v:
Oncogene. 17(7)
Two distinct pathways for completion of base excision repair (BER) have been discovered in eukaryotes: the DNA polymerase beta (Pol beta)-dependent short-patch pathway that involves the replacement of a single nucleotide and the long-patch pathway th