Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Tzyy-Wen Chiou"'
Publikováno v:
Tzu-Chi Medical Journal, Vol 33, Iss 2, Pp 122-127 (2021)
Alzheimer's disease (AD) is a neurodegenerative disease with a variety of causes. Traditional Chinese medicine (TCM), which includes the two main approaches of acupuncture and herbal medication, views the human body as a self-controlled system networ
Externí odkaz:
https://doaj.org/article/3fb1c068e42f4381835d80d106242bf7
Publikováno v:
Tzu-Chi Medical Journal, Vol 32, Iss 2, Pp 113-120 (2020)
Exosomes, 60-200-nm extracellular vesicles secreted from cells, have been used as an active pharmaceutical ingredient or drug carrier in disease treatment. Human- and plant-derived exosomes are registered in clinical trials, but more complete reports
Externí odkaz:
https://doaj.org/article/3ffa698069ec4788987d32cb9de5fdff
Autor:
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching-I Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2883 (2022)
Retinal pigmented epithelial (RPE) cells possess high mitochondria content for energy production, which is required for phagocytosis and vision cycle metabolism. The mitochondrial integrity in RPE cells helps the homeostasis of photoreceptor turnover
Externí odkaz:
https://doaj.org/article/d6fd512db1684aceadcf9f78e93e6335
Autor:
Hsiao-Chien Ting, Hong-Lin Su, Mei-Fang Chen, Horng-Jyh Harn, Shinn-Zong Lin, Tzyy-Wen Chiou, Chia-Yu Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13462 (2022)
Human pluripotent stem cell (hPSC)-derived motor neurons (MNs) act as models for motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS) or spinal muscular atrophy. However, the MN differentiation efficiency and viability following
Externí odkaz:
https://doaj.org/article/46dcde4890f14eefafdf129cba716348
Autor:
Wei Wuli, Shinn-Zong Lin, Shee-Ping Chen, Bakhos A. Tannous, Wen-Sheng Huang, Peng Yeong Woon, Yang-Chang Wu, Hsueh-Hui Yang, Yi-Cheng Chen, Renata Lopes Fleming, Jack T. Rogers, Catherine M. Cahill, Tsung-Jung Ho, Tzyy-Wen Chiou, Horng-Jyh Harn
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10554 (2022)
Presenilin-1 (PSEN1) is a crucial subunit within the γ-secretase complex and regulates β-amyloid (Aβ) production. Accumulated evidence indicates that n-butylidenephthalide (BP) acts effectively to reduce Aβ levels in neuronal cells that are deriv
Externí odkaz:
https://doaj.org/article/e71022bbf83e4230b93d793420625efb
Autor:
Chia-Yu Chang, Hsiao-Chien Ting, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin, Tsung-Jung Ho
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Human pluripotent stem cells (hPSCs) are sources of several somatic cell types for human developmental studies, in vitro disease modeling, and cell transplantation therapy. Improving strategies of derivation of high-purity specific neural and glial l
Externí odkaz:
https://doaj.org/article/19e6e33b787640fd9267f2eb9a798cff
Autor:
Ching-Ann Liu, Wei-Hsiu Liu, Hsin-I Ma, Yuan-Hao Chen, Dueng-Yuan Hueng, Wen-Chiuan Tsai, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Jen-Wei Liu, Jui-Hao Lee, Tsung-Lang Chiu
Publikováno v:
Cancers, Vol 14, Iss 4, p 1051 (2022)
In recurrent glioblastoma, Gliadel wafer implantation after surgery has been shown to result in incomplete chemical removal of residual tumor and development of brain edema. Furthermore, temozolomide (TMZ) resistance caused by O6-methylguanine-DNA-me
Externí odkaz:
https://doaj.org/article/0094a1155e044e648df9824ca8ef0d5c
Autor:
Christine Chang, Jen-Wei Liu, Bo Cheng Chen, Zhe Sheng Jiang, Chi Tang Tu, Che Hung Su, Hsin Han Yang, Zong Qi Liu, Yu Chen Deng, Chih Yu Chen, Sheng-Tzung Tsai, Shinn Zong Lin, Tzyy-Wen Chiou
Publikováno v:
Cell Transplantation, Vol 29 (2020)
Patients with multiple system atrophy (MSA), a progressive neurodegenerative disorder of adult onset, were found less than 9 years of life expectancy after onset. The disorders include bradykinesia and rigidity commonly seen in Parkinsonism disease a
Externí odkaz:
https://doaj.org/article/85e7ed77e3ee4c979063f4ab66717be5
Autor:
Hsin-Han Yang, I-Tsang Chiang, Jen-Wei Liu, Jeanne Hsieh, Jui-Hao Lee, Huai-En Lu, Hwa-Sung Tso, Yu-Chen Deng, Jo-Chi Kao, Jhen-Rong Wu, Horng-Jyh Harn, Tzyy-Wen Chiou
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1391 (2022)
Spinocerebellar ataxia type 3 (SCA3) is characterized by the over-repetitive CAG codon in the ataxin-3 gene (ATXN3), which encodes the mutant ATXN3 protein. The pathological defects of SCA3 such as the impaired aggresomes, autophagy, and the proteaso
Externí odkaz:
https://doaj.org/article/99c025697dde47e4bec9d38f6fd28839
Autor:
Ko-Chang Huang, Ming-Hsi Chuang, Zung-Sheng Lin, Yi-Chun Lin, Chun-Hung Chen, Chao-Liang Chang, Pi-Chun Huang, Wan-Sin Syu, Tzyy-Wen Chiou, Zih-Han Hong, Yu-Chen Tsai, Horng-Jyh Harn, Po-Cheng Lin, Shinn-Zong Lin
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Currently, the only effective therapy for cirrhosis of the liver is liver transplantation. However, finding a compatible liver is difficult due to the low supply of healthy livers and the ever-increasing demand. However, stem-cell therapy may offer a
Externí odkaz:
https://doaj.org/article/54ae61e1368e4408815d3464d74f598d