Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Tzyy Nan Huang"'
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002646 (2024)
Autism spectrum disorders (ASDs) are considered neural dysconnectivity syndromes. To better understand ASD and uncover potential treatments, it is imperative to know and dissect the connectivity deficits under conditions of autism. Here, we apply a w
Externí odkaz:
https://doaj.org/article/9190e9a0a2f0453983e3c146e54fddb1
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102290- (2023)
Summary: Synaptopathy, which encompasses morphological deficits and any abnormal protein distribution of synapses, is a critical feature of many neurological diseases. We here provide a protocol using mice stably expressing a Thy1-YFP transgene to as
Externí odkaz:
https://doaj.org/article/b8145b0642d9404c8b1f3866a6eed28c
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-18 (2020)
Abstract Background Dendritic spines, the actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain. Many actin-regulating molecules modulate dendritic spine morphology. Since dendriti
Externí odkaz:
https://doaj.org/article/2990e166d76f40158b42912c504e9d01
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-16 (2019)
Abstract Background Autism spectrum disorders (ASD) exhibit two clusters of core symptoms, i.e., social and communication impairment, and repetitive behaviors and sensory abnormalities. Our previous study demonstrated that TBR1, a causative gene of A
Externí odkaz:
https://doaj.org/article/7b086e58e5854fb28456dd338096fc28
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101949- (2021)
Summary: Both genetic variations and nutritional deficiency are associated with autism spectrum disorders and other neurological disorders. However, it is less clear whether or how nutritional deficiency and genetic variations influence each other un
Externí odkaz:
https://doaj.org/article/056428542bc84c8fbd6a468379699fa5
Autor:
Pu-Yun Shih, Bing-Yuan Hsieh, Ming-Hui Lin, Tzyy-Nan Huang, Ching-Yen Tsai, Wen-Li Pong, Sue-Ping Lee, Yi-Ping Hsueh
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: Synaptic dysregulation is a critical feature of autism spectrum disorders (ASDs). Among various autism-associated genes, cortactin binding protein 2 (CTTNBP2) is a cytoskeleton regulator predominantly expressed in neurons and highly enriched
Externí odkaz:
https://doaj.org/article/4705c044a0114ade85d5375f647d0732
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107835- (2020)
Summary: Neurofibromatosis type 1 (NF1) is a dominant genetic disorder manifesting, in part, as cognitive defects. Previous study indicated that neurofibromin (NF1 protein) interacts with valosin-containing protein (VCP)/P97 to control dendritic spin
Externí odkaz:
https://doaj.org/article/6d1ddbf8978747b1a3520f5720b232a1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The two hemispheres of the vertebrate brain are connected through several commissures. Although the anterior commissure (AC) is the most conserved white matter structure in the brains of different vertebrates, its complete physiological functionality
Externí odkaz:
https://doaj.org/article/36203b6ed64e490285fc3a49609f1a30
Autor:
Tzu-Li Yen, Tzyy-Nan Huang, Ming-Hui Lin, Tsan-Ting Hsu, Ming-Hsuan Lu, Pu-Yun Shih, Jacob Ellegood, Jason Lerch, Yi-Ping Hsueh
Publikováno v:
Brain. 146:2612-2626
Autism spectrum disorders caused by both genetic and environmental factors are strongly male-biased neuropsychiatric conditions. However, the mechanism underlying the sex bias of autism spectrum disorders remains elusive. Here, we use a mouse model i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e6ece795b10726d4d0363cd8e2be4d
https://doi.org/10.1093/brain/awac429
https://doi.org/10.1093/brain/awac429
Autor:
Tzyy-Nan Huang, Tsan-Ting Hsu, Ming-Hui Lin, Hsiu-Chun Chuang, Hsiao-Tang Hu, Cheng-Pu Sun, Mi-Hua Tao, John Y. Lin, Yi-Ping Hsueh
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 34-48.e4 (2019)
Summary: Impaired interhemispheric connectivity is commonly found in various psychiatric disorders, although how interhemispheric connectivity regulates brain function remains elusive. Here, we use the mouse amygdala, a brain region that is critical
Externí odkaz:
https://doaj.org/article/2ff79722249e40269b089631aef4f2e1