Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tzutshin Wong"'
Autor:
Kevin R. Alliston, Tzutshin Wong, Swathi Mohan, Zhong Lai, Nga T. Vu, Christopher S. Groutas, William C. Groutas, Norman M. Schechter
Publikováno v:
Archives of Biochemistry and Biophysics. 436:1-7
We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine protease tryptase. The inhibitors were readily obtained by attaching various heterocyclic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a518414731795613c5a7bf23d5da5a
https://doi.org/10.1016/j.abb.2005.01.022
https://doi.org/10.1016/j.abb.2005.01.022
Autor:
Tzutshin Wong, David M. Eichhorn, William C. Groutas, Christopher S. Groutas, Kevin R. Alliston, Zhong Lai, John R. Hoidal, Jiaying Zhong, Xiangdong Gan
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:6249-6254
The pathogenesis of a range of human diseases arises from the aberrant activity of proteolytic enzymes. Agents capable of selectively modulating the activity of these enzymes are of potential therapeutic value. Thus, there is a continuing need for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846aba63fcdaf7e7d13ad90ffc9bbc3a
https://doi.org/10.1016/j.bmc.2004.08.044
https://doi.org/10.1016/j.bmc.2004.08.044
Autor:
Zhong Lai, Kevin R. Alliston, William C. Groutas, Tzutshin Wong, Xiangdong Gan, Jiaying Zhong, Christopher S. Groutas, Hongyi Yu
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd18400faad750031c5bcb127e0fa1b1
https://doi.org/10.1002/chin.200444143
https://doi.org/10.1002/chin.200444143
Autor:
Kevin R. Alliston, Christopher S. Groutas, Jiaying Zhong, Xiangdong Gan, William C. Groutas, Tzutshin Wong, Zhong Lai, Hongyi Yu
Publikováno v:
Journal of combinatorial chemistry. 6(4)
Exploratory studies related to the design and synthesis of functionalized cyclic sulfamides (I) as potential inhibitors of proteolytic enzymes were carried out. The structural motif and three diversity sites embodied in the scaffold render it amenabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d0d7e54617129aacc7b2237914a145
https://pubmed.ncbi.nlm.nih.gov/15244417
https://pubmed.ncbi.nlm.nih.gov/15244417