Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Tzuhua Lin"'
Autor:
Hirohito Hirata, Ning Zhang, Masaya Ueno, Danial Barati, Junichi Kushioka, Huaishuang Shen, Masanori Tsubosaka, Masakazu Toya, Tzuhua Lin, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang, Stuart B. Goodman
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Despite the high incidence of fractures and pseudoarthrosis in the aged population, a potential role for the use of mesenchymal stem cells (MSCs) in the treatment of bone defects in elderly patients has not been elucidated. Inflam
Externí odkaz:
https://doaj.org/article/4e47b8d5e4ec43a6a039cdfb7fe1fce0
Autor:
Ning Zhang, Takeshi Utsunomiya, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Ejun Huang, Claire Rhee, Zhenyu Yao, Stuart B. Goodman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Wear particles from total joint arthroplasties (TJAs) induce chronic inflammation, macrophage infiltration and lead to bone loss by promoting bone destruction and inhibiting bone formation. Inhibition of particle-associated chronic inflammation and t
Externí odkaz:
https://doaj.org/article/332f48442ae748e9b278e78ff0ed5e85
Autor:
Masaya Ueno, Ning Zhang, Hirohito Hirata, Danial Barati, Takeshi Utsunomiya, Huaishuang Shen, Tzuhua Lin, Masahiro Maruyama, Ejun Huang, Zhenyu Yao, Joy Y. Wu, Stefan Zwingenberger, Fan Yang, Stuart B. Goodman
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Mesenchymal stem cell (MSC)-based therapy and novel biomaterials are promising strategies for healing of long bone critical size defects. Interleukin-4 (IL-4) over-expressing MSCs within a gelatin microribbon (µRB) scaffold was previously shown to e
Externí odkaz:
https://doaj.org/article/bff4714009c849f2861241bb573887e4
Autor:
Takeshi Utsunomiya, Ning Zhang, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Claire Rhee, Ejun Huang, Zhenyu Yao, Stuart B. Goodman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Chronic inflammation is a common feature in many diseases of different organ systems, including bone. However, there are few interventions to mitigate chronic inflammation and preserve host tissue. Previous in vitro studies demonstrated that precondi
Externí odkaz:
https://doaj.org/article/4f5da5a03ba94294b69e67c9b3a3439e
Autor:
Stuart B. Goodman, Tzuhua Lin
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Healing of fractures and bone defects normally follows an orderly series of events including formation of a hematoma and an initial stage of inflammation, development of soft callus, formation of hard callus, and finally the stage of bone remodeling.
Externí odkaz:
https://doaj.org/article/37972b384c104caf80f80ec46250cd93
Autor:
Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao, Stuart B. Goodman
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-9 (2017)
Abstract Background Mesenchymal stem cells (MSCs) are capable of immunomodulation and tissue regeneration, highlighting their potential translational application for treating inflammatory bone disorders. MSC-mediated immunomodulation is regulated by
Externí odkaz:
https://doaj.org/article/bdb9c4a9a385448699e152d9a02873a1
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
When presented with an adverse stimulus, organisms evoke an immediate, pre-programmed, non-specific innate immune response. The purpose of this reaction is to maintain the organism's biological integrity and function, mitigate or eradicate the injuri
Externí odkaz:
https://doaj.org/article/7523bb26bad74ad7bbde26172c80b6cb
Autor:
Akira Nabeshima, Tahsin N. Khan, Taishi Sato, Zhenyu Yao, Eemeli Jämsen, Emmanuel Gibon, Stuart B. Goodman, Tzuhua Lin, Jukka Pajarinen
Publikováno v:
J Biomed Mater Res A
Periprosthetic osteolysis remains as a major complication of total joint replacement surgery. Modulation of macrophage polarization with interleukin-4 (IL-4) has emerged as an effective means to limit wear particle-induced osteolysis. The aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d389684f6a72bad30bfffaa24887f8
https://doi.org/10.1002/jbm.a.37142
https://doi.org/10.1002/jbm.a.37142
Autor:
Monica Romero-Lopez, Chi-Wen Lo, Claire Rhee, Rebecca Dubowitz, Tzuhua Lin, Jukka Pajarinen, Zhong Li, John Hanlon, Bruce A. Bunnell, Benjamen O’Donnell, Hang Lin, Zhenyu Yao, Masahiro Maruyama, Stuart B. Goodman, Rocky S. Tuan
Publikováno v:
Tissue Engineering Part A. 26:1099-1111
As musculoskeletal (MSK) disorders continue to increase globally, there is an increased need for novel, in vitro models to efficiently study human bone physiology in the context of both healthy and diseased conditions. For these models, the inclusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e56538435dfcdc924e08f3cdc1aa4d0
https://doi.org/10.1089/ten.tea.2020.0041
https://doi.org/10.1089/ten.tea.2020.0041
Autor:
Danial Barati, Claire Rhee, Tzuhua Lin, Fan Yang, Ejun Huang, Ning Zhang, Yusuke Kohno, Stefan Zwingenberger, Monica Romero-Lopez, Zhenyu Yao, Masaya Ueno, Stuart B. Goodman, Bogdan Conrad, Takeshi Utsunomiya, Chi-Wen Lo, Masahiro Maruyama, Xinming Tong
Publikováno v:
J Biomed Mater Res A
Mesenchymal stem cell (MSC)-based therapy is a promising strategy for bone repair. Furthermore, the innate immune system, and specifically macrophages, plays a crucial role in the differentiation and activation of MSCs. The anti-inflammatory cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2e5592a6df2eabc980b8b98ddc7dc
https://doi.org/10.1002/jbm.a.36982
https://doi.org/10.1002/jbm.a.36982