Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tzuen Yih Saw"'
Autor:
Susana P. Egusquiaguirre, Suhu Liu, Isidora Tošić, Kevin Jiang, Sarah R. Walker, Maria Nicolais, Tzuen Yih Saw, Michael Xiang, Katarina Bartel, Erik A. Nelson, David A. Frank
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 1, Pp 47-59 (2020)
The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, thro
Externí odkaz:
https://doaj.org/article/0f1cc32cc4fa4d529fb5cf2e51cc4247
Publikováno v:
Redox Biology, Vol 4, Iss C, Pp 308-320 (2015)
Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatop
Externí odkaz:
https://doaj.org/article/a183d62c5eb14522963187a9663b6db9
Autor:
Katarina Bartel, David A. Frank, Maria Nicolais, Suhu Liu, Kevin Jiang, Michael Xiang, Erik A. Nelson, Isidora Tošić, Sarah R. Walker, Susana P. Egusquiaguirre, Tzuen Yih Saw
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 1, Pp 47-59 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The transcription factor STAT3 regulates genes governing critical cellular processes such as proliferation, survival, and self-renewal. While STAT3 transcriptional function is activated rapidly and transiently in response to physiologic signals, thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cf80ee3ee967c77f904340659b0f08
http://www.sciencedirect.com/science/article/pii/S147655861930209X
http://www.sciencedirect.com/science/article/pii/S147655861930209X
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8697c6f995cc7793d964608a1b5c4531
https://pubmed.ncbi.nlm.nih.gov/34288055
https://pubmed.ncbi.nlm.nih.gov/34288055
Autor:
Chee Wai Fong, San Choon Kong, Kee Pah Lim, Jordan Petkov, Tzuen Yih Saw, Wei Ney Yap, Esther Sook Miin Wong, Cheryl Wei Ling Teo, Najib Abdul Malik
Publikováno v:
Journal of Nutritional Science and Vitaminology. 65:318-327
Ulcerative colitis (UC) is characterized by damaged colonic mucosa and submucosa layers that are caused by excessive inflammatory reactions and oxidative stress. This study aimed to examine the use of tocotrienol-rich fraction (TRF) in mitigating dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e845b187415a640e06ffcd39612dcad
https://doi.org/10.3177/jnsv.65.318
https://doi.org/10.3177/jnsv.65.318
Publikováno v:
Redox Biology, Vol 4, Iss C, Pp 308-320 (2015)
Redox Biology
Redox Biology
Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ab142df2b33df5b74bd59e3a7042d9
http://www.sciencedirect.com/science/article/pii/S2213231715000142
http://www.sciencedirect.com/science/article/pii/S2213231715000142
Publikováno v:
Toxicology in Vitro. 19:145-154
The aim was to compare the use of different cell-material contact test methods with two different biological systems (cell line and tooth slice cultures) for cytotoxicity assessment of dental materials. Cytotoxicity of composites polymerized with two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09499531379af7fcac1fd3b986187f00
https://doi.org/10.1016/j.tiv.2004.08.006
https://doi.org/10.1016/j.tiv.2004.08.006
Autor:
Chia-Tien Chang, Min Zhang, S. Tiong Ong, An Qi Lim, Sharon Xiaodai Lim, Kassoum Nacro, Soo Yong Tan, Hung Fan, Charles Chuah, David A. Rizzieri, David A. Fruman, Jeffrey Hill, Tzuen Yih Saw, Matthew R. Janes
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Chronic myeloid leukemia responds well to therapy targeting the oncogenic fusion protein BCR-ABL1 in chronic phase, but is resistant to treatment after it progresses to blast crisis (BC). BC is characterized by elevated β-catenin signaling in granul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6658fa846d7e354df7347c7785bd36c3
https://doi.org/10.1073/pnas.1301838110
https://doi.org/10.1073/pnas.1301838110
Autor:
Dieu-Hung Lao, Tzuen Yih Saw, Chye Yun Yu, Chee Wai Fong, Permeen Yusoff, Sumana Chandramouli, Rebecca A. Jackson, Graeme R. Guy, Robin J. Philp
Publikováno v:
The Journal of biological chemistry. 282(12)
In the context of fibroblast growth factor (FGF) signaling, Sprouty2 (Spry2) is the most profound inhibitor of the Ras/ERK pathway as compared with other Spry isoforms. An exclusive, necessary, but cryptic PXXPXR motif in the C terminus of Spry2 is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1262186062259ee24a065960e1f00594
https://pubmed.ncbi.nlm.nih.gov/17255109
https://pubmed.ncbi.nlm.nih.gov/17255109
Autor:
Chee Wai Fong, Hwei Fen Leong, Chye Yun Yu, Permeen Yusoff, Lai Peng Tai, Tzuen Yih Saw, Sumana Chandramouli, Dieu-Hung Lao, Graeme R. Guy
Publikováno v:
The Journal of biological chemistry. 281(40)
Because the Sprouty (Spry) proteins were shown to be inhibitors of the mainstream Ras/ERK pathway, there has been considerable interest in ascertaining their mechanism of action especially since a possible role as tumor suppressors for these inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bee318df659d2d0542415d14ee4966b
https://pubmed.ncbi.nlm.nih.gov/16893902
https://pubmed.ncbi.nlm.nih.gov/16893902