Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tzu-Lang Chen"'
Publikováno v:
Molecules, Vol 27, Iss 22, p 8015 (2022)
Primary liver cancer is the fifth leading death of cancers in men, and hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancer cases. Sorafenib is a first-line drug for advanced-stage HCC patients. Sorafenib is a mul
Externí odkaz:
https://doaj.org/article/58d842b9d31641f2aea0db9d1e82d3fa
Autor:
Yuan-Hsi Wang, Fat-Moon Suk, Chao-Lien Liu, Tzu-Lang Chen, Yuh-Ching Twu, Ming-Hua Hsu, Yi-Jen Liao
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Hepatic stellate cells (HSCs) are the major profibrogenic cells that promote the pathogenesis of liver fibrosis. The crosstalk between transforming growth factor-β1 (TGF-β1) signaling and lipopolysaccharide (LPS)-induced NF-κB signaling plays a cr
Externí odkaz:
https://doaj.org/article/ccbc78ac3d6d44d0a03ba68121acccde
Autor:
Yi-Jen Liao, Meng-Wei Lin, Chia-Hung Yen, Yu-Ting Lin, Chung-Kwe Wang, Shiu-Feng Huang, Kuan-Hsuan Chen, Ching-Ping Yang, Tzu-Lang Chen, Ming-Feng Hou, Yi-Ming Arthur Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77586 (2013)
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. However, little is known about the significance of NPC2 in cancer. In this study, we have pinpoin
Externí odkaz:
https://doaj.org/article/3b4f7bf6085b47ccba95eab8a859c50f
Autor:
Tzu-Lang Chen, 陳次郎
97
Glycine N-methyltransferase (GNMT) is a tumor suppressor gene for liver cancer. It affects DNA methylation and DNA stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine and binding to folate. GNMT also serves as
Glycine N-methyltransferase (GNMT) is a tumor suppressor gene for liver cancer. It affects DNA methylation and DNA stability by regulating the ratio of S-adenosylmethionine to S-adenosylhomocysteine and binding to folate. GNMT also serves as
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/79839328086210735445
Publikováno v:
The Journal of Nutritional Biochemistry. 115:109267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8190476d75a3b32de7013e3828d99651
https://doi.org/10.1016/j.jnutbio.2023.109267
https://doi.org/10.1016/j.jnutbio.2023.109267
Autor:
Fat Moon Suk, Yuan Hsi Wang, Chien Ying Wu, Tzu Lang Chen, Chiao Fan Liu, Wan Chun Chiu, Yi Jen Liao
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8567, p 8567 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8567, p 8567 (2021)
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor in the world. Sorafenib is the first-line drug for patients with advanced HCC. However, long-term treatment with sorafenib often results in reduced sensitivity of tumor cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7850ae806dad4a337ed5eb35b4795429
Autor:
Yi Jen Liao, Tzong Shyuan Lee, Yi Ming Arthur Chen, Shiu Feng Huang, Li Ying Liao, Ren Shyan Liu, Chung Kwe Wang, Hsiang An Wang, Tzu Lang Chen
Publikováno v:
Molecular Medicine. 18:412-422
Nonalcoholic fatty liver disease (NAFLD) is associated with the development of metabolic syndromes and hepatocellular carcinoma (HCC). Cholesterol accumulation is related to NAFLD, whereas its detailed mechanism is not fully understood. Previously, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc74959d066d080aebabdfdecd94b7e9
https://doi.org/10.2119/molmed.2011.00258
https://doi.org/10.2119/molmed.2011.00258
Autor:
Yi-Jen Liao, Tzu-Lang Chen, Tzong-Shyuan Lee, Hsiang-An Wang, Chung-Kwe Wang, Liao, Li-Ying, Ren-Shyan Liu, Shiu-Feng Huang, Chen, Yi-Ming
Glycine N-Methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259a16f3564b29c1e48f3004d4378a9e
Autor:
Yi Jen Liao, Chau Heng Chien, Tzu Lang Chen, Shih Ping Liu, Chung Kwe Wang, Shiu Feng Huang, Ting Fen Tsai, Yi Ming Arthur Chen, Kuan Hsuan Chen
Publikováno v:
Proteomics. Clinical applications. 4(4)
Purpose: Previously, we reported that glycine N-methyltransferase (GNMT) interacts with benzo[a]pyrene (BaP) and inhibits BaP-DNA adducts formation. In addition, Gnmt knockout (Gnmt−/−) mice developed chronic hepatitis and hepatocellular carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2f05f61de42bfa418c4bbf136f35ca
https://pubmed.ncbi.nlm.nih.gov/21137059
https://pubmed.ncbi.nlm.nih.gov/21137059
Autor:
Yi-Jen Liao1, Tzu-Lang Chen1, Tzong-Shyuan Lee2, Hsiang-An Wang1, Chung-Kwe Wang3, Li-Ying Liao4, Ren-Shyan Liu5, Shiu-Feng Huang6, Yi-Ming Arthur Chen1,7,8 arthur@ym.edu.tw
Publikováno v:
Molecular Medicine. Mar2012, Vol. 18 Issue 3, p412-422. 15p.