Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tzu-Lan Yeh"'
Publikováno v:
npj Quantum Information, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Prediction of tautomers plays an essential role in computer-aided drug discovery. However, it remains a challenging task nowadays to accurately predict the canonical tautomeric form of a given drug-like molecule. Lack of extensive tautomer d
Externí odkaz:
https://doaj.org/article/37e7089f569f4addb3e5077c3ca8c3cc
Autor:
Tzu-Lan Yeh, 葉姿蘭
93
By using x-ray scattering and multiple diffraction techniques, this study seeks to revisit the dynamic transition of charge density waves in K0.3MoO3, a quasi-one-dimensional charge-density-wave material, under applied voltage. The three-wave
By using x-ray scattering and multiple diffraction techniques, this study seeks to revisit the dynamic transition of charge density waves in K0.3MoO3, a quasi-one-dimensional charge-density-wave material, under applied voltage. The three-wave
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/38890970499072998491
Prediction of tautomers plays an essential role in computer-aided drug discovery. However, it remains a challenging task nowadays to accurately predict the canonical tautomeric form of a given drug-like molecule. Lack of extensive tautomer databases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d208236a02c6a66de6bbc25de90e9477
Autor:
Martine I. Abboud, William D. Figg, Anthony Tumber, Gareth W. Langley, Kerstin Lippl, Christopher W. Pugh, Tzu-Lan Yeh, Christopher T. Lohans, Rasheduzzaman Chowdhury, Peter J. Ratcliffe, Christopher J. Schofield, James P. Holt-Martyn, Michael A. McDonough
Publikováno v:
Chemmedchem
The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late
Autor:
Christian R. Wick, Nicole Orth, Kerstin Fey, Eva Heinze, Anthony Tumber, Martine I. Abboud, Timothy Clark, Björn Buchholz, Gunnar Schley, Nicolai Burzlaff, Marleen Mayer, Tzu-Lan Yeh, Christopher J. Schofield, Carsten Willam
Publikováno v:
ChemMedChem. 14:94-99
Prolyl hydroxylation domain (PHD) enzymes catalyze the hydroxylation of the transcription factor hypoxia‐inducible factor (HIF) and serve as cellular oxygen sensors. HIF and the PHD enzymes regulate numerous potentially tissue‐protective target g
Autor:
Isabelle Moneke, Roland Schüle, Erik Schleicher, Akane Kawamura, Silke Lassmann, Hanna Tarhonskaya, Dina Robaa, Kuo-Feng Hsu, Martine I. Abboud, Rebecca L. Hancock, Wolfgang Sippl, Henriette Franz, Kerstin Lippl, Christopher J. Schofield, Nicolas P F Barthes, Theresa D. Ahrens, Manfred Jung, Sarah E. Wilkins, Sandra Wenzler, Martin Roatsch, Tzu Lan Yeh, Inga Hoffmann, Sven Diederichs, Kerstin Serrer
Publikováno v:
ACS chemical biology. 14(8)
Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are epigenetic eraser enzymes involved in the regulation of gene expression and are emerging drug targets in oncology. We screened a set of clinica
Autor:
Manfred Jung, Martin Roatsch, Inga Hoffmann, Martine I. Abboud, Rebecca L. Hancock, Hanna Tarhonskaya, Kuo-Feng Hsu, Sarah E. Wilkins, Tzu-lan Yeh, Kerstin Lippl, Kerstin Serrer, Isabelle Moneke, Theresa D. Ahrens, Dina Robaa, Sandra Wenzler, Henriette Franz, Wolfgang Sippl, Silke Lassmann, Sven Diederichs, Erik Schleicher, Christopher J. Schofield, Akane Kawamura, Roland Schüle
Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are epigenetic eraser enzymes involved in the regulation of gene expression and are emerging drug targets in oncology. We screened a set of clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e472f20dd442521931b9fcd32e8099d
https://doi.org/10.26434/chemrxiv.7699853
https://doi.org/10.26434/chemrxiv.7699853
Autor:
Emily Flashman, Cyrille C. Thinnes, Christopher W. Pugh, Anthony Tumber, Kerstin Lippl, Rasheduzzaman Chowdhury, James P. Holt-Martyn, Ivanhoe K. H. Leung, Christopher J. Schofield, Timothy D. W. Claridge, Dong Zhang, Peter J. Ratcliffe, Thomas M. Leissing, Akane Kawamura, Tzu-Lan Yeh, Xin Lu, Christopher T. Lohans, Ian J. Clifton, Martine I. Abboud, Helen Morcrette, Onur Atasoylu
Publikováno v:
'Chemical Science ', vol: 8, pages: 7651-7668 (2017)
Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1–3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe cellular, bioph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918d41d85b4f6b3a130b75a3f25860f0
https://doi.org/10.1039/c7sc02103h
https://doi.org/10.1039/c7sc02103h
Autor:
Alexandra Giatromanolaki, Efthimios Sivridis, Christopher J. Schofield, Christos E. Zois, Martine I. Abboud, Dimitra Kalamida, C. Simopoulos, Michael I. Koukourakis, Adrian L. Harris, Tzu-Lan Yeh, Savvas P. Tokmakidis, Ilias V. Karagounis, Stamatia Pouliliou, Timothy D. W. Claridge
Publikováno v:
Scientific Reports
The mechanism of Amifostine (WR-2721) mediated radioprotection is poorly understood. The effects of amifostine on human basal metabolism, mouse liver metabolism and on normal and tumor hepatic cells were studied. Indirect calorimetric canopy tests sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388b9a910a18f9c4c62b6968bc2c8c05
https://doi.org/10.1038/srep30986
https://doi.org/10.1038/srep30986
Autor:
Rachel Schiller, Jacob T. Bush, G Scozzafava, James Wickens, Ganesha Rai, Bryan T. Mott, Akane Kawamura, Anthony Tumber, Clarisse Lejeune, Mun Chiang Chan, Tzu-Lan Yeh, James S. O. McCullagh, Hwanho Choi, David J. Maloney, Christopher J. Schofield
Publikováno v:
ChemMedChem
Chemmedchem
Chemmedchem
The 2-oxoglutarate (2OG)-dependent Jumonji C domain (JmjC) family is the largest family of histone lysine demethylases. There is interest in developing small-molecule probes that modulate JmjC activity to investigate their biological roles. 5-Carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1052dfdee934f6f0cda848f1ab26d89f
https://ora.ox.ac.uk/objects/uuid:cc2a3734-4a5d-4aa5-b621-f371f424091f
https://ora.ox.ac.uk/objects/uuid:cc2a3734-4a5d-4aa5-b621-f371f424091f