Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Tzu-Kang Sang"'
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Transactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the br
Externí odkaz:
https://doaj.org/article/2dd5abe025f24522a5522a7f507980b3
Autor:
Ya-Chu Chang, Yu-Xiang Peng, Bo-Hua Yu, Henry C. Chang, Pei-Shin Liang, Ting-Yi Huang, Chao-Jie Shih, Li-An Chu, Tzu-Kang Sang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Cells maintain a constant cytoplasm to nucleus volume ratio, although the role of DNA damage is not well explored. Here, the authors use Drosophila to connect TER94, the fly homolog of VCP, to disruption of DNA damage repair, leading to ubiquitinated
Externí odkaz:
https://doaj.org/article/a98e31b8568b4570a73299717fbf8dd4
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101430- (2022)
Summary: The adult Drosophila compound eye is an ideal in vivo model for studying biological questions. However, light microscopy of this tissue requires cumbersome embedding and sectioning. Here, we document detailed whole-mount procedures for immun
Externí odkaz:
https://doaj.org/article/d3babca89d064c709519af086311c2f0
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-11 (2018)
Abstract Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurode
Externí odkaz:
https://doaj.org/article/09e32575c0f84fc3b37d7db170bc58ad
Autor:
Cyong-Jhih Liang, Ya-Chu Chang, Henry C Chang, Chung-Kang Wang, Yu-Chien Hung, Ying-Er Lin, Chia-Ching Chan, Chun-Hong Chen, Hui-Yun Chang, Tzu-Kang Sang
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004675 (2014)
Mutations in VCP (Valosin-containing protein), an AAA ATPase critical for ER-associated degradation, are linked to IBMPFD (Inclusion body myopathy with Paget disease and frontotemporal dementia). Using a Drosophila IBMPFD model, we have identified th
Externí odkaz:
https://doaj.org/article/df6a857e18bb458baecd4cb72562d104
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 3, Iss 2, p 19 (2016)
Valosin-containing protein (VCP) is a highly conserved mechanoenzyme that helps maintain protein homeostasis in all cells and serves specialized functions in distinct cell types. In skeletal muscle, it is critical for myofibrillogenesis and atrophy.
Externí odkaz:
https://doaj.org/article/db80b5018d5842c9a13da8036c8355cb
Autor:
Ya-Chu Chang, Wan-Tzu Hung, Yun-Chin Chang, Henry C Chang, Chia-Lin Wu, Ann-Shyn Chiang, George R Jackson, Tzu-Kang Sang
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001288 (2011)
Inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) is caused by mutations in Valosin-containing protein (VCP), a hexameric AAA ATPase that participates in a variety of cellular processes such as protein degradat
Externí odkaz:
https://doaj.org/article/f23b0eb21649402aaea7f70140adef5b
Publikováno v:
Frontiers in Genetics; 3/9/2023, Vol. 14, p1-15, 15p
Autor:
Chih-Ping Hung, Cheng-Yuan Lin, Tzu-Kang Sang, Hui-Yun Chang, Ann-Shyn Chiang, Li-An Chu, Jia-Chi Wang, Jing-Yi Jeng, Lee Sun
Dopamine (DA) is an essential neurotransmitter modulating motor and cognitive functions. Several neurological disorders, including Parkinson’s disease (PD) and drug addiction, are the result of DA system dysfunction; however, it remains incomplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8344e70543e9b596fc2f8fd23c9d3ef
https://doi.org/10.1101/2020.09.04.283911
https://doi.org/10.1101/2020.09.04.283911
Autor:
Lee Sun, Ren-Huei Shiu, Rui Han, Hao Chi, Chung-Chuan Lo, Hui-Yun Chang, Tzu-Min Wei, Tzu-Kang Sang, Chien-Ping Hsieh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Hyperphosphorylated and truncated tau variants are enriched in neuropathological aggregates in diseases known as tauopathies. However, whether the interaction of these posttranslational modifications affects tau toxicity as a whole remains unresolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97aed9ceb8b1d80e516c63f0bbd2299
http://europepmc.org/articles/PMC7417559
http://europepmc.org/articles/PMC7417559