Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors

Autor: Tony Eight Lin, Li-Chin Sung, Min-Wu Chao, Min Li, Jia-Huei Zheng, Tzu-Ying Sung, Jui-Hua Hsieh, Chia-Ron Yang, Hsueh-Yun Lee, Er-Chieh Cho, Kai-Cheng Hsu

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 226-235 (2022)

Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent i

Externí odkaz: https://doaj.org/article/4eee7f20c593416abeb5853c9de04c92

ACR11 modulates levels of reactive oxygen species and salicylic acid-associated defense response in Arabidopsis

Autor: Shashi Kant Singh, Tzu-Ying Sung, Tsui-Yun Chung, Shao-Yu Lin, Sang-Chu Lin, Jo-Chien Liao, Wei-Yu Hsieh, Ming-Hsiun Hsieh

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)

Abstract The ACT domain (aspartate kinase, chorismate mutase and TyrA), an allosteric effector binding domain, is commonly found in amino acid metabolic enzymes. In addition to ACT domain-containing enzymes, plants have a novel family of ACT domain r

Externí odkaz: https://doaj.org/article/8ef539a3f5f944f0b2640f3ec0334312

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Autor: Tony Eight Lin, Wei-Chun HuangFu, Min-Wu Chao, Tzu-Ying Sung, Chao-Di Chang, Yi-Ying Chen, Jui-Hua Hsieh, Huang-Ju Tu, Han-Li Huang, Shiow-Lin Pan, Kai-Cheng Hsu

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the path

Externí odkaz: https://doaj.org/article/53feeaf4e47a4482ada47bbc6e155336

Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors

Autor: Jui-Yi Hsu, Kai-Cheng Hsu, Ching Sun, Ching-Hsuan Chou, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Shih-Chung Yen, Chia-Ron Yang, Wei-Jan Huang

Publikováno v: Biomedicine & Pharmacotherapy. 159:114258

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c181638690d86f44a0cafeba15fd391f
https://doi.org/10.1016/j.biopha.2023.114258

Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

Autor: Kai Cheng Hsu, Tony Eight Lin, Liang Chieh Chen, Huang Ju Tu, Chia-Ron Yang, Min Wu Chao, Wei Chun HuangFu, Shiow Lin Pan, Tzu Ying Sung, Wei Jan Huang, Shih Chung Yen, Chao Di Chang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 98-108 (2021)

The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa48ff72915f71f9bb552eb8d86b042f
http://europepmc.org/articles/PMC7655034