Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126

Autor: Tzu-Wei Tan, Chin-Jung Hsu, Wei-Hung Yang, Ying-Erh Chou, Yi-Chin Fong, Chih-Hsin Tang

Publikováno v: International Immunopharmacology. 22:107-114

Chondrosarcoma, a primary malignant bone cancer, has a potent capacity to invade locally and cause distant metastasis, especially to the lungs. Patients diagnosed with it have poor prognosis. Naringin, polymethoxylated flavonoid commonly found in cit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1658193e82ca4982a7e130ba150256
https://doi.org/10.1016/j.intimp.2014.06.029

D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways

Autor: Chi-Cheng Chen, Wen Chi Chen, Chih-Hsin Tang, Tzu-Wei Tan, Tien-Huang Lin, Shang-Sen Lee, Hsin-Ho Liu, Teng-Fu Hsieh, Tsung-Hsun Tsai

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 9790-9802 (2013)
International Journal of Molecular Sciences; Volume 14; Issue 5; Pages: 9790-9802
International Journal of Molecular Sciences

Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. D-pinitol, a 3-methoxy analogue of d-chiro-inositol, was identified as an active principle in soy foods and legumes, and it has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1ff895b2b4585728d9333a7d79c86a
http://www.mdpi.com/1422-0067/14/5/9790

CCN3 increases BMP-4 expression and bone mineralization in osteoblasts

Autor: Chih-Hsin Tang, Horng-Chaung Hsu, Der Yang Cho, Chien-Chung Kuo, Jen Jyh Lin, Tzu Wei Tan, Yi Hung Chen, Yi-Chin Fong, Chun-Hao Tsai, Jung Tzu Chang, Yuan Lin Huang, Yen-Jen Chen

Publikováno v: Journal of Cellular Physiology. 227:2531-2541

The nephroblastoma overexpressed (NOV) gene, also called CCN3, regulates differentiation of skeletal mesenchymal cells. Bone morphogenetic proteins (BMPs) play important roles in osteoblast differentiation and bone formation, but the effects of CCN3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0067f6d55a008fc728ac9f945a27833
https://doi.org/10.1002/jcp.22991

The novel isoflavone derivatives inhibit RANKL-induced osteoclast formation

Autor: Ju Fang Liu, Tzu Wei Tan, Chih-Hsin Tang, Chih-Shiang Chang, Shan Chi Liu

Publikováno v: European Journal of Pharmacology. 648:59-66

Isoflavones are compounds structurally similar to the mammalian estrogens and have received considerable attention for their preventive actions on bone loss. Here, we synthesized the novel isoflavone derivatives and examined their activities in bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88403f9eddb66188d0dabc87194e3c9b
https://doi.org/10.1016/j.ejphar.2010.08.052

CTGF enhances migration and MMP-13 up-regulation via αvβ3 integrin, FAK, ERK, and NF-κB-dependent pathway in human chondrosarcoma cells

Autor: Chih-Hsin Tang, Tzu-Wei Tan, Horng-Chaung Hsu, Wei-Hung Yang, Chih Ho Lai, Yi-Chin Fong, Hsien-Te Chen, Chun-Yiu Huang

Publikováno v: Journal of Cellular Biochemistry. 107:345-356

Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7d833259a576c04a883195f95d5e20
https://doi.org/10.1002/jcb.22132