Výsledky vyhledávání - "Tzu L. Phang"

Akademický článek

Platelet Gene Expression as a Biomarker Risk Stratification Tool in Acute Myocardial Infarction: A Pilot Investigation

Autor: David C. Calverley, Ivan P. Casserly, Qamrul G. Choudhury, Tzu L. Phang, Bifeng Gao, John C. Messenger, Mark W. Geraci

Publikováno v: Clinical Medicine Insights: Blood Disorders, Vol 2010, Iss 3, Pp 9-15 (2010)

Platelets play a major role in the pathophysiology of acute myocardial infarction (AMI). Recent evidence reveals megakaryocyte-derived platelet pre-mRNA is spliced to mRNA and then translated into functional proteins in response to external stimulati

Externí odkaz: https://doaj.org/article/5fe8b5d582f44d77b6c005ab7607ecec

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HLA homozygosity is associated with Non-Hodgkin lymphoma

Autor: Christina L, Roark, Bethany E, Ho, Michael T, Aubrey, Cheri, Anobile, Sapir, Israeli, Tzu L, Phang, Danielle, Braxton, Andrea P, Ho, Brian M, Freed

Publikováno v: Human Immunology. 83:730-735

The "heterozygote advantage" hypothesis has been postulated regarding the role of human leukocyte antigen (HLA) in non-Hodgkin lymphoma (NHL), where homozygous loci are associated with an increased risk of disease. In this retrospective study, we ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1df7e8c9a7c2d25f5fa84cefe17a4e5
https://doi.org/10.1016/j.humimm.2022.08.002

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Building a Vertically-Integrated Genomic Learning Health System: The Colorado Center for Personalized Medicine Biobank

Precision medicine initiatives across the globe have led to a revolution of repositories linking large-scale genomic data with electronic health records, enabling genomic analyses across the entire phenome. Many of these initiatives focus solely on r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8471beca0a0725070c7875392f2fbde9
https://doi.org/10.1101/2022.06.09.22276222

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JMJD5 couples with CDK9 to release the paused RNA polymerase II

Publikováno v: Proc Natl Acad Sci U S A

More than 30% of genes in higher eukaryotes are regulated by RNA polymerase II (Pol II) promoter proximal pausing. Pausing is released by the positive transcription elongation factor complex (P-TEFb). However, the exact mechanism by which this occurs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4bc0587078cd17f5e2fd8c86b37513
https://doi.org/10.1073/pnas.2005745117

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Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans

Autor: Anna Kerege, Bryan C. Bergman, Allison Strauss, Dominik Lutter, Daniel H. Bessesen, Darcy E. Kahn, Kathleen A. Harrison, Leigh Perreault, Tzu L. Phang, Sean A. Newsom, Elisabeth Graf, Jan Krumsiek, Simona Zarini, Stephan Sachs, Thomas Schwarzmayr, Susanna M. Hofmann, Jonathan A. Schoen

Publikováno v: Am. J. Physiol. Endocrinol. Metab. 316, E866-E879 (2019)
Am J Physiol Endocrinol Metab

Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in humans to test for the ability to induce insulin resistance in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f7692fa312bcb0f71ce51fae138624
https://doi.org/10.1152/ajpendo.00243.2018

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Low-Coverage Whole Genome Sequencing Using Laser Capture Microscopy with Combined Digital Droplet PCR: An Effective Tool to Study Copy Number and Kras Mutations in Early Lung Adenocarcinoma Development

Autor: Mark W. Geraci, Huaxin Zhou, Catherine R. Sears, Robert S Stearman, Elizabeth A. Mickler, Tzu L. Phang

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12034, p 12034 (2021)

Defining detailed genomic characterization of early tumor progression is critical to identifying key regulators and pathways in carcinogenesis as potentially druggable targets. In human lung cancer, work to characterize early cancer development has m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eea64bb0d8857c6d4355c5b03b0da8d
https://doi.org/10.3390/ijms222112034

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Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy

Autor: Sarah K. Sasse, Reynold A. Panettieri, Tzu L. Phang, Anthony N. Gerber, Vineela Kadiyala, Thomas Danhorn

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 57:226-237

Glucocorticoids exert important therapeutic effects on airway smooth muscle (ASM), yet few direct targets of glucocorticoid signaling in ASM have been definitively identified. Here, we show that the transcription factor, Krüppel-like factor 15 (KLF1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d0d744ffd68af7436b18c0e9d9b8b0
https://doi.org/10.1165/rcmb.2016-0357oc

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