Targeting the interaction of pleiotrophin and VEGFA165 with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis

Autor: Choleva, Effrosyni, Menounou, Lydia, Ntenekou, Despoina, Kastana, Pinelopi, Tzoupis, Ηaralampos, Katraki-Pavlou, Stamatiki, Drakopoulou, Maria, Spyropoulos, Dimitrios, Andrikopoulou, Anastasia, Kanellopoulou, Vasiliki, Enake, Michaela-Karina, Beis, Dimitris, Papadimitriou, Evangelia

Publikováno v: In European Journal of Pharmacology 15 August 2024 977

Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on α ν β 3 integrin expression.

Autor: Lamprou M; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Kastana P; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Kofina F; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Tzoupis Η; Department of Chemistry, University of Patras, Patras, Greece., Barmpoutsi S; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Sajib MS; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA., Koutsioumpa M; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece.; Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA., Poimenidi E; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece.; Dual Training in Intensive Care Medicine and Anaesthesia, Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, UK., Zompra AA; Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Tassopoulos D; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Choleva E; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece., Tselios T; Department of Chemistry, University of Patras, Patras, Greece., Mikelis CM; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA., Papadimitriou E; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. epapad@upatras.gr.

Publikováno v: Angiogenesis [Angiogenesis] 2020 Nov; Vol. 23 (4), pp. 621-636. Date of Electronic Publication: 2020 Jul 17.