How to develop a controlled human infection model for Clostridioides difficile.

Autor: Hensen ADO; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands., Vehreschild MJGT; Department of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; German Center for Infection Research (DZIF), Cologne, Germany., Gerding DN; Department of Veterans Affairs, Edward Hines Jr VA Hospital, Hines, IL, United States., Krut O; Paul-Ehrlich-Institut (PEI), Langen, Germany., Chen W; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States., Young VB; Department of Internal Medicine/Infectious Diseases Division and the Department of Microbiology & Immunology, The University of Michigan, Ann Arbor, MI, United States., Tzipori S; Division of Infectious Disease and Global Health, Tufts University, Medford, MA, United States., Solbach P; First Department of Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany., Gibani MM; Department of Infectious Disease, Imperial College London (ICL), London, United Kingdom., Chiu C; Department of Infectious Disease, Imperial College London (ICL), London, United Kingdom., de Keersmaecker SCJ; Transversal Activities in Applied Genomics, Sciensano, Brussels, Belgium., Dasyam D; GSK, Rixensart, Belgium., Morel S; GSK, Rixensart, Belgium., Devaster JM; GSK, Rixensart, Belgium., Corti N; European Vaccine Initiative (EVI), Heidelberg, Germany., Kuijper EJ; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands., Roestenberg M; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands. Electronic address: m.roestenberg@lumc.nl., Smits WK; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Publikováno v: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2024 Aug 29. Date of Electronic Publication: 2024 Aug 29.

PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.

Autor: Shepard RM; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Ghebremedhin A; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Pratumchai I; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Robinson SR; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; New England Regional Biosafety Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Betts C; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA., Hu J; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Sasik R; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA., Fisch KM; Center for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Zak J; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Chen H; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Paradise M; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Rivera J; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Amjad M; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Uchiyama S; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Seo H; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Campos AD; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Dayao DA; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA., Piedra-Mora C; Department of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Das S; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Hasteh F; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Russo H; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Sun X; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Xu L; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Crotty Alexander LE; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Duran JM; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Odish M; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Pretorius V; Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA., Kirchberger NC; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA., Chin SM; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Von Schalscha T; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Cheresh D; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Morrey JD; Institute for Antiviral Research, Animal, Dairy, and Veterinary Science, Utah State University, Logan, UT 84322, USA., Alargova R; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., O'Connell B; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., Martinot TA; Infinity Pharmaceuticals, Cambridge, MA 02138, USA., Patel SP; Department of Medicine/Medical Oncology, University of California, San Diego, La Jolla, CA 92093, USA., Nizet V; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Martinot AJ; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; New England Regional Biosafety Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.; Department of Comparative Pathobiology, Section of Pathology, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA., Coussens LM; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA., Teijaro JR; Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA., Varner JA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Jul 03; Vol. 16 (754), pp. eadi6887. Date of Electronic Publication: 2024 Jul 03.

Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies.

Autor: Debatis M; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Danz H; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Tremblay JM; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Gaspie K; Division of Animal Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Kudej RK; Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Vigdorovich V; Center for Global Infectious Disease Research, Seattle Children's Hospital, Seattle, WA, United States of America., Sather N; Center for Global Infectious Disease Research, Seattle Children's Hospital, Seattle, WA, United States of America., Jaskiewicz JJ; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America., Shoemaker CB; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States of America.

Publikováno v: PloS one [PLoS One] 2023 Nov 27; Vol. 18 (11), pp. e0291937. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).

Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies.

Autor: Thran M; CureVac SE, 72076, Tübingen, Germany., Pönisch M; CureVac SE, 72076, Tübingen, Germany., Danz H; Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA., Horscroft N; CureVac SE, 72076, Tübingen, Germany., Ichtchenko K; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, 10016, USA., Tzipori S; Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA., Shoemaker CB; Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA. charles.shoemaker@tufts.edu.

Publikováno v: Scientific reports [Sci Rep] 2023 Sep 05; Vol. 13 (1), pp. 14632. Date of Electronic Publication: 2023 Sep 05.

Characterization of WRSs2 and WRSs3, new second-generation virG(icsA)-based Shigella sonnei vaccine candidates with the potential for reduced reactogenicity

Autor: Barnoy, S., Jeong, K.I., Helm, R.F., Suvarnapunya, A.E., Ranallo, R.T., Tzipori, S., Venkatesan, M.M.

Publikováno v: In Vaccine 10 February 2010 28(6):1642-1654