Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Tzipora Goldkorn"'
Autor:
Simone Filosto, Elaine M Khan, Emiliana Tognon, Cathleen Becker, Majid Ashfaq, Tommer Ravid, Tzipora Goldkorn
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23240 (2011)
Crystallographic studies have offered understanding of how receptor tyrosine kinases from the ErbB family are regulated by their growth factor ligands. A conformational change of the EGFR (ErbB1) was shown to occur upon ligand binding, where a solely
Externí odkaz:
https://doaj.org/article/ad7c71ddeaeb48ff8095e88b9c2d16a6
The EGF receptor (EGFR) and its downstream signaling are implicated in lung cancer development. Therefore, much effort was spent in developing specific tyrosine kinase inhibitors (TKI) that bind to the EGFR ATP-pocket, blocking EGFR phosphorylation/s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325091d5fce579e687513e256da0cd4d
https://doi.org/10.1158/1535-7163.c.6536080
https://doi.org/10.1158/1535-7163.c.6536080
PDF file - 1448K, Phosphorylation of Y845-EGFR does not control the CS-driven aberrant EGFR activation, nor the subsequent TKI resistance. A. Serum starved NIH-3T3 cells stably over expressing either WT or Y845F MT EGFR were incubated (or not) with 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200318cf6ac8c8faa3567e7bac6710fc
https://doi.org/10.1158/1535-7163.22501135.v1
https://doi.org/10.1158/1535-7163.22501135.v1
PDF file - 359K, Aberrant CS-dependent activation of Src is inhibited by PP1 and PP2, Src Family Kinase (SFK) inhibitors. A549 cells were incubated (or not) for 30' with 10microM PP1-PP2 (5-5 microM) and then treated, or not (-), with EGF (100 ng/ml)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658e105fa91ff104a6384fe23ba81c6d
https://doi.org/10.1158/1535-7163.22501141.v1
https://doi.org/10.1158/1535-7163.22501141.v1
PDF file - 902K, Src binds to EGFR under CS exposure in a manner that is not exclusively dependent on Src or EGFR kinase activity. A. Serum starved A549 cells were incubated for 30' with 10 microM Src family kinase inhibitors, PP1-PP2 (5-5 microM), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010f630e82f3bed42fe2825e7464d668
https://doi.org/10.1158/1535-7163.22501138.v1
https://doi.org/10.1158/1535-7163.22501138.v1