Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Tzintzuni Garcia"'
Autor:
Tatiana L. Fonseca, Tzintzuni Garcia, Gustavo W. Fernandes, T. Murlidharan Nair, Antonio C. Bianco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence
Externí odkaz:
https://doaj.org/article/5587b3ecf19b472a84494cfe82d8da0a
Autor:
Michael Princiotta, Arjun Balar, Gary Steinberg, Randy Sweis, Guilhem Richard, Tzintzuni Garcia, Matthew Ardito, William Martin, Gad Berdugo, Anne de Groot
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/f8c302c3585a41be8045150f5ef3f8ed
Autor:
Alvaro N. Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, Heather E. Wheeler, Jason M. Torres, Eric S. Torstenson, Kaanan P. Shah, Tzintzuni Garcia, Todd L. Edwards, Eli A. Stahl, Laura M. Huckins, GTEx Consortium, Dan L. Nicolae, Nancy J. Cox, Hae Kyung Im
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variat
Externí odkaz:
https://doaj.org/article/74f1758878ad410698934b8de48e83e1
Autor:
Heather E Wheeler, Kaanan P Shah, Jonathon Brenner, Tzintzuni Garcia, Keston Aquino-Michaels, GTEx Consortium, Nancy J Cox, Dan L Nicolae, Hae Kyung Im
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006423 (2016)
Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the heritability and the distribution of effect sizes acro
Externí odkaz:
https://doaj.org/article/ce2c5a4a51da475dbdc271bd21549451
Autor:
Antonio C. Bianco, Gustavo W. Fernandes, Tzintzuni Garcia, Tatiana L. Fonseca, T. Murlidharan Nair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific
Autor:
Raymond Powell, Phuong-My Do, Mark A. Jensen, Tanja Davidsen, Michael S. Fitzsimons, Karl Rademacher, Daniel P. Miller, Ariz Zubair, Christina K. Yung, Francisco M. Ortuño, Stuti Agrawal, Allison Heath, James C. Angelakos, Kim Cullion, Shenglai Li, Yajing Tang, Janice Lodato, Martin L. Ferguson, Gajanan Ganji, Liming Yang, Kang Han, Sid Joshi, Jesús Pedrosa, Lincoln Stein, Zhining Wang, Jeffrey A. Mazzone, Plamen Martinov, Bessie Rogel, Alex Wilmer, Yuanheng Zhao, Vincent Ferretti, Mathangi Thiagarajan, Zhenyu Zhang, Francois Gerthoffert, Koji Miyauchi, Christian Dompierre, Jonathan Spring, Kaman Wu, Laxmi Lolla, Kyle M. Hernandez, Heather D. Troyer, Ian J. Miller, William P. Wysocki, Joseph Sislow, Linda Xiang, Mark W. Murphy, Joshua S. Miller, Jeffrey Burt, James J. Porter, Shane Wilson, Maksim An, Robert L. Grossman, Sean Sullivan, Bilal Baqar, Renuka Arya, Joseph Tadashi Yamada, Daniela S. Gerhard, Miyuki Fukuma, Maxim Y. Popov, Rosita Bajari, Thomas Nullet, Tara M. Lichtenberg, Jeremiah Savage, Tzintzuni Garcia, Fauzi Gomez, Samantha Rich, Louis M. Staudt, Bedford L. West, Ajinkya Kadam, Kyle A. Schmitt, Phuong L. Pham, Richard Jackson, Michael Ford, Sharon Gaheen, Himanso Sahni, Rowland O. Ogwara, Chang Wang, Victoria E. Kraft, Aishmit Khurana, Sameera S. George, Fay Chu, Colin P. Reid, Christine Yu, Jean C. Zenklusen, Ann Catton, Biju Issac, Justin H. B. Barnowski, Kyle M. J. Kim, Brandon F. Chan, Trevar J. Simmons, Junjun Zhang
Publikováno v:
Nature Genetics. 53:257-262
The National Cancer Institute (NCI) Genomic Data Commons (GDC) contains more than 2.9 petabytes of genomic and associated clinical data from more than 60 NCI-funded and other contributed cancer genomics research projects. The GDC consists of five app
Autor:
Sonia L Hernandez, Henar Cuervo, Jessica J Kandel, Fernando Flores-Guzman, Tzintzuni Garcia, Peter Hahn, Rebecca Kirschner, Ann M Defnet, Naina Bagrodia, Mildred Nelson, Henry Biermann, Stephanie Shen, Lydia L Wu
Publikováno v:
Vascular Cell. 13
Autor:
Michael F. Princiotta, Anne S. De Groot, Randy F. Sweis, Matthew Ardito, Tzintzuni Garcia, William D. Martin, Alec Kacew, Gary D. Steinberg, Gad Berdugo, Arjun Vasant Balar, Guilhem Richard
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Improvement of risk stratification through prognostic biomarkers may enhance the personalization of cancer patient monitoring and treatment. We used Ancer, an immunoinformatic CD8, CD4, and regulatory T cell neoepitope screening system, to perform an
Autor:
Gad Berdugo, Randy F. Sweis, Michael F. Princiotta, Gary D. Steinberg, Guilhem Richard, Anne S. De Groot, Matthew Ardito, Tzintzuni Garcia, Arjun Vasant Balar, William J. Martin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Improvement of current prognosis biomarkers will enhance our ability to identify cancer patients at higher risk of recurrence and will further advance the personalization of patient monitoring and treatment. We hypothesized that the presen
Autor:
Stuti Agrawal, Plamen Martinov, Kaman Wu, Raymond Powell, Louis M. Staudt, Chang Wang, Tanja Davidsen, Bessie Rogel, Yuanheng Zhao, Aishmit Khurana, Joshua S. Miller, Thomas Nullet, Zhining Wang, Michael S. Fitzsimons, Daniela S. Gerhard, Maxim Y. Popov, Fay Chu, Colin P. Reid, Christine Yu, Sharon Gaheen, Kim Cullion, Junjun Zhang, Allison Heath, Phuong L. Pham, Himanso Sahni, Rowland O. Ogwara, Jeremiah Savage, Gajanan Ganji, Jeffrey A. Mazzone, Lincoln Stein, Kyle A. Schmitt, Bedford L. West, Vincent Ferretti, Alex Wilmer, Jesús Pedrosa, Fauzi Gomez, Zhenyu Zhang, William P. Wysocki, Renuka Arya, Mark W. Murphy, Ajinkya Kadam, Victoria E. Kraft, Linda Xiang, Jean C. Zenklusen, Trevar J. Simmons, Maksim An, Shane Wilson, Heather D. Troyer, Samantha Rich, Ian J. Miller, Jeffrey Burt, Daniel P. Miller, James C. Angelakos, Tzintzuni Garcia, Richard Jackson, Phuong-My Do, Michael Ford, Ann Catton, Laxmi Lolla, Kyle M. Hernandez, Francisco M. Ortuño, Sean Sullivan, Bilal Baqar, Sameera S. George, Martin L. Ferguson, Koji Miyauchi, Biju Issac, Mark A. Jensen, Robert L. Grossman, Shenglai Li, Joseph Tadashi Yamada, Karl Rademacher, Joseph Sislow, Tara M. Lichtenberg, Sid Joshi, Christina K. Yung, Mathangi Thiagarajan, James J. Porter, Miyuki Fukuma, Rosita Bajari, Kang Han, Francois Gerthoffert, Janice Lodato, Justin H. B. Barnowski, Kyle M. J. Kim, Brandon F. Chan, Ariz Zubair, Yajing Tang, Liming Yang, Christian Dompierre, Jonathan Spring
Publikováno v:
Nature Genetics. 53:935-935