Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways.

Autor: Hsu CH; Department of Emergency Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei City, 11031, Taiwan; Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Weng PW; Department of Orthopaedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Department of Orthopaedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan., Chen MY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang Ho Hospital, New Taipei City, 23561, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Yeh CT; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang Ho Hospital, New Taipei City, 23561, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan; Continuing Education Program of Food Biotechnology Applications, College of Science and Engineering, National Taitung University, Taitung, 95092, Taiwan., Setiawan SA; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Yadav VK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang Ho Hospital, New Taipei City, 23561, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan., Wu ATH; Ph.D. Program of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan., Tzeng DTW; School of Life Sciences, The Chinese University of Hong Kong, 999077, Hong Kong Special Administrative Region of China; Lifebit, London, EC2A 2AP, UK., Gong JX; Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China; Shenzhen Bay Laboratory, Shenzhen, 518055, China., Yang Z; Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China; State Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education and Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China; Shenzhen Bay Laboratory, Shenzhen, 518055, China. Electronic address: zyang@pku.edu.cn., Tzeng YM; Department of Applied Science, National Taitung University, Taitung, 95092, Taiwan; Department of Applied Chemistry, Chaoyang University of Technology, Taichung, 41349, Taiwan. Electronic address: ymtzeng@nttu.edu.tw.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2023 Jan 25; Vol. 370, pp. 110329. Date of Electronic Publication: 2022 Dec 22.

Transcriptomic discovery of a theranostic signature (SERPINE1/MMP3/COL1A1/SPP1) for head and neck squamous cell carcinomas and identification of antrocinol as a candidate drug.

Autor: Shih ML; Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan., Lee JC; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Chenggong Road, Taipei, 114, Taiwan., Cheng SY; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Chenggong Road, Taipei, 114, Taiwan., Lawal B; UPMC Hillman Cancer Center, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Graduate Institute for Cancer Biology & Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address: bashirlawal12@gmail.com., Ho CL; Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan., Wu CC; Department of Radiation Oncology, Columbia Irving University Medical Center, Manhattan, NY, USA., Tzeng DTW; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, 999077, China., Chen JH; Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan., Wu ATH; The PhD Program of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 110, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 110, Taiwan; Clinical Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, 110, Taiwan; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 110, Taiwan. Electronic address: chaw1211@tmu.edu.tw.

Publikováno v: Computers in biology and medicine [Comput Biol Med] 2022 Nov; Vol. 150, pp. 106185. Date of Electronic Publication: 2022 Oct 17.

Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate.

Autor: Wu ATH; The Ph.D. Program of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Clinical Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan., Lawal B; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.; Graduate Institute for Cancer Biology & Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., Wei L; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan.; Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei 11031, Taiwan., Wen YT; Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei 11031, Taiwan., Tzeng DTW; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China., Lo WC; School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan.

Publikováno v: Pharmaceutics [Pharmaceutics] 2021 Sep 24; Vol. 13 (10). Date of Electronic Publication: 2021 Sep 24.

Effects of artificial light at night (ALAN) on gene expression of Aquatica ficta firefly larvae.

Autor: Chen YR; Department of Entomology, National Taiwan University, Taiwan., Wei WL; Institute of Biotechnology, National Taiwan University, Taiwan., Tzeng DTW; School of Life Sciences, The Chinese University of Hong Kong, China., Owens ACS; Department of Entomology, National Taiwan University, Taiwan., Tang HC; Taipei Zoo, Conservation and Research Center, Taiwan., Wu CS; Tree Garden Company, Taiwan., Lin SS; Institute of Biotechnology, National Taiwan University, Taiwan., Zhong S; School of Life Sciences, The Chinese University of Hong Kong, China., Yang EC; Department of Entomology, National Taiwan University, Taiwan. Electronic address: ecyang@ntu.edu.tw.

Publikováno v: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Jul 15; Vol. 281, pp. 116944. Date of Electronic Publication: 2021 Mar 26.

The Gut Microbiome Is Associated with Clinical Response to Anti-PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer.

Autor: Peng Z; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Cheng S; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Kou Y; Xbiome, Shenzhen, China., Wang Z; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Jin R; Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Medical Immunology (Ministry of Health), Peking University, Beijing, China., Hu H; Xbiome, Shenzhen, China., Zhang X; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Gong JF; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Li J; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Lu M; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Wang X; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Zhou J; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Lu Z; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China., Zhang Q; Xbiome, Shenzhen, China., Tzeng DTW; Xbiome, Shenzhen, China., Bi D; Xbiome, Shenzhen, China., Tan Y; Xbiome, Shenzhen, China. shenlin@bjmu.edu.cn yant@xbiome.com., Shen L; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. shenlin@bjmu.edu.cn yant@xbiome.com.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2020 Oct; Vol. 8 (10), pp. 1251-1261. Date of Electronic Publication: 2020 Aug 27.