Adenovirus-mediated expression of MOAP-1, Bax and RASSF1A antagonizes chemo-drug resistance of human breast cancer cells expressing cancer stem cell markers

Autor: Ee Wern Tan, Amar Daud Iskandar Abdullah, Long Chiau Ming, Chit Laa Poh, Bey Hing Goh, Tze Pheng Lau, Kuan Onn Tan

Publikováno v: Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116744- (2024)

Cancer is one of the major leading causes of mortality globally and chemo-drug-resistant cancers pose significant challenges to cancer treatment by reducing patient survival rates and increasing treatment costs. Although the mechanisms of chemoresist

Externí odkaz: https://doaj.org/article/11e0dda9558e489c9e574098bdd6f361

Correction: Assessment of Telomere Length in Archived Formalin-Fixed, Paraffinized Human Tissue Is Confounded by Chronological Age and Storage Duration.

Autor: Po-Lian Kong, Lai-Meng Looi, Tze-Pheng Lau, Phaik-Leng Cheah

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168238 (2016)

[This corrects the article DOI: 10.1371/journal.pone.0161720.].

Externí odkaz: https://doaj.org/article/14302db0b0b043e78ec24ad62cd61f7b

Association between PDCD1 Gene Polymorphisms and Risk of Systemic Lupus Erythematosus in Three Main Ethnic Groups of the Malaysian Population

Autor: Lay-Hoong Lian, Tze Pheng Lau, Xiu Jia Sim, Kek Heng Chua, T E Cheah

Publikováno v: International Journal of Molecular Sciences
Volume 16
Issue 5
Pages 9794-9803
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 9794-9803 (2015)

The programmed cell death 1 (PDCD1) gene encodes for the PD-1 (programmed death 1) molecule, which negatively regulates self-reactive T- and B-cells in the maintenance of peripheral tolerance. A previous report had shown the development of lupus-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c698a174e25f33477578f56c01b51936
https://doi.org/10.3390/ijms16059794

NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer

Autor: Ping Chin Lee, Ida Hilmi, L.H. Lian, April Camilla Roslani, Kek Heng Chua, Khean-Lee Goh, Tze Pheng Lau

Publikováno v: Genetics and Molecular Research. 13:7079-7085

Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9083982650a98424a1fffd752f25fc
https://doi.org/10.4238/2014.march.19.3

Genetic Polymorphisms of the Interleukin-1 beta (IL-1.BETA.) -511 and +3954 Single Nucleotide Polymorphisms (SNPs) in Malaysian Systemic Lupus Erythematosus (SLE) Patients

Autor: Lay-Hoong Lian, Kek Heng Chua, Tze-Pheng Lau, S.Y. Tan, Zhuang-Yun Tee

Publikováno v: Journal of Health Science. 55:657-662

Systemic lupus erythematosus (SLE) is an autoimmune disorder whereby the immune system's components act upon our body's self-antigens. The pathogenesis is mainly due to the hyperactivity of T helper cells and B lymphocytes, as well as an abnormal apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::112cfc4aced1defbe79bed7c1144e6c3
https://doi.org/10.1248/jhs.55.657