Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Tze K, Lau"'
Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing.
Autor:
Eric Z Chen, Rossa W K Chiu, Hao Sun, Ranjit Akolekar, K C Allen Chan, Tak Y Leung, Peiyong Jiang, Yama W L Zheng, Fiona M F Lun, Lisa Y S Chan, Yongjie Jin, Attie T J I Go, Elizabeth T Lau, William W K To, Wing C Leung, Rebecca Y K Tang, Sidney K C Au-Yeung, Helena Lam, Yu Y Kung, Xiuqing Zhang, John M G van Vugt, Ryoko Minekawa, Mary H Y Tang, Jun Wang, Cees B M Oudejans, Tze K Lau, Kypros H Nicolaides, Y M Dennis Lo
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21791 (2011)
Massively parallel sequencing of DNA molecules in the plasma of pregnant women has been shown to allow accurate and noninvasive prenatal detection of fetal trisomy 21. However, whether the sequencing approach is as accurate for the noninvasive prenat
Externí odkaz:
https://doaj.org/article/79bcfe2a4cb842b498a88221fab38ddf
Autor:
Dana W Y Tsui, Y M Doris Lam, Wing S Lee, Tak Y Leung, Tze K Lau, Elizabeth T Lau, Mary H Y Tang, Ranjit Akolekar, Kypros H Nicolaides, Rossa W K Chiu, Y M Dennis Lo, Stephen S C Chim
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15069 (2010)
BACKGROUND: Noninvasive prenatal diagnosis of fetal aneuploidy by maternal plasma analysis is challenging owing to the low fractional and absolute concentrations of fetal DNA in maternal plasma. Previously, we demonstrated for the first time that fet
Externí odkaz:
https://doaj.org/article/7d90812ce3f54b7d970b0abfb0cce9a4
Autor:
Yu K Tong, Rossa W K Chiu, Ranjit Akolekar, Tak Y Leung, Tze K Lau, Kypros H Nicolaides, Y M Dennis Lo
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15244 (2010)
BACKGROUND: The putative promoter of the holocarboxylase synthetase (HLCS) gene on chromosome 21 is hypermethylated in placental tissues and could be detected as a fetal-specific DNA marker in maternal plasma. Detection of fetal trisomy 21 (T21) has
Externí odkaz:
https://doaj.org/article/f19c720cb318488a803636a4e4e16669
Autor:
Macy M S Heung, Shengnan Jin, Nancy B Y Tsui, Chunming Ding, Tak Y Leung, Tze K Lau, Rossa W K Chiu, Y M Dennis Lo
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5858 (2009)
BACKGROUND:Placental mRNA was detected in maternal whole blood, raising the possibility of using maternal blood for noninvasive prenatal diagnosis. We investigated fetal mRNA detection in maternal whole blood and determined if it offered advantages o
Externí odkaz:
https://doaj.org/article/a2f6e058596948d6b622f534a0e20e96
Autor:
Tak Yeung Leung, K.C. Allen Chan, Claudia Chi, Rezan A. Kadir, Rossa W.K. Chiu, Gillian Mellars, Nancy B.Y. Tsui, Edward G. D. Tuddenham, Y.M. Dennis Lo, Tze K. Lau
Publikováno v:
Blood. 117:3684-3691
Hemophilia is a bleeding disorder with X-linked inheritance. Current prenatal diagnostic methods for hemophilia are invasive and pose a risk to the fetus. Cell-free fetal DNA analysis in maternal plasma provides a noninvasive mean of assessing fetal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1874d73bddc4c4b6f61b2a5751a8c1
https://doi.org/10.1182/blood-2010-10-310789
https://doi.org/10.1182/blood-2010-10-310789
Autor:
Katherine C.K. Chow, Tak Yeung Leung, Rossa W.K. Chiu, Y.M. Dennis Lo, Kypros H. Nicolaides, Ranjit Akolekar, Nancy B.Y. Tsui, Tze K. Lau
Publikováno v:
Clinical Chemistry. 56:73-81
Background: Maternal plasma mRNA encoded by the PLAC4 gene (placenta-specific 4), which is transcribed from chromosome 21 in placental cells, is a potential marker for the noninvasive assessment of chromosome 21 dosage in the fetus. We evaluated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6d1fa30c592546c366e77bfc7fe535
https://doi.org/10.1373/clinchem.2009.132662
https://doi.org/10.1373/clinchem.2009.132662
Autor:
Rossa W.K. Chiu, Tze K. Lau, Blenda C.K. Wong, Y.M. Dennis Lo, Nancy B.Y. Tsui, Tak Yeung Leung
Publikováno v:
Prenatal Diagnosis. 29:1031-1037
Objective Non-invasive prenatal diagnosis of chromosome aneuploidies has been achieved by measuring the ratio of two alleles of a single nucleotide polymorphism (SNP) in circulating placental mRNA (the RNA–SNP allelic ratio approach) in maternal pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74053f72016731fa16529e0ac4692bb1
https://doi.org/10.1002/pd.2340
https://doi.org/10.1002/pd.2340
Autor:
Michelle H. Y. Tsui, Tze K. Lau, Daljit Singh Sahota, Tak Yeung Leung, Y.M. Dennis Lo, Winnie W. I. Pang, Rossa W.K. Chiu
Publikováno v:
Prenatal Diagnosis. 29:495-504
Objective To evaluate whether circulating placental mRNAs in maternal plasma could serve as markers for the assessment of fetal growth or intrauterine growth restriction (IUGR). Methods From a panel of placental transcripts detectable in maternal pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f370c7e7fb14c397b4e68cecab554cb9
https://doi.org/10.1002/pd.2230
https://doi.org/10.1002/pd.2230
Autor:
Torpong Sanguansermsri, Fiona M.F. Lun, K.C. Allen Chan, Charles R. Cantor, Nancy B.Y. Tsui, Chanane Wanapirak, Tak Yeung Leung, Tze K. Lau, Y.M. Dennis Lo, Katherine C.K. Chow, Pimlak Charoenkwan, Wyatt Y. W. Lo, Rossa W.K. Chiu
Publikováno v:
Proceedings of the National Academy of Sciences. 105:19920-19925
Prenatal diagnosis of monogenic diseases, such as cystic fibrosis and β-thalassemia, is currently offered as part of public health programs. However, current methods based on chorionic villus sampling and amniocentesis for obtaining fetal genetic ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fb3e6974327b41360ff3ddd319f413
https://doi.org/10.1073/pnas.0810373105
https://doi.org/10.1073/pnas.0810373105
Autor:
Lisa Y.S. Chan, Wing Shan Lee, Yu K. Tong, Tak Yeung Leung, Shengnan Jin, Chunming Ding, Ningning Yang, Y.M. Dennis Lo, Rossa W.K. Chiu, Yongjie Jin, Tze K. Lau, Tracy Yuen Han Lee, Fiona M.F. Lun, Stephen S.C. Chim
Publikováno v:
Clinical Chemistry. 54:500-511
Background: The presence of fetal DNA in maternal plasma represents a source of fetal genetic material for noninvasive prenatal diagnosis; however, the coexisting background maternal DNA complicates the analysis of aneuploidy in such fetal DNA. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29048e18464c5e118de58ae952d1cea4
https://doi.org/10.1373/clinchem.2007.098731
https://doi.org/10.1373/clinchem.2007.098731