Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tze How Mok"'
Autor:
Tze How Mok, Akin Nihat, Connie Luk, Danielle Sequeira, Mark Batchelor, Simon Mead, John Collinge, Graham S. Jackson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or re
Externí odkaz:
https://doaj.org/article/df04884ac887422694fcb1d5a25cc4e0
Autor:
David Mengel, Tze How Mok, Akin Nihat, Wen Liu, Robert A. Rissman, Douglas Galasko, Henrik Zetterberg, Simon Mead, John Collinge, Dominic M. Walsh
Publikováno v:
Cells, Vol 10, Iss 12, p 3514 (2021)
This study investigates the diagnostic and prognostic potential of different forms of tau in biofluids from patients with Creutzfeldt-Jakob disease (CJD). Extracellular tau, which is molecularly heterogeneous, was measured using ultra-sensitive custo
Externí odkaz:
https://doaj.org/article/cdbdd2558fdc456aa6bffb6167e61b9a
Autor:
Nicholas Brennecke, Ignazio Cali, Tze How Mok, Helen Speedy, Genomics England Research Consortium, Laszlo L. P. Hosszu, Christiane Stehmann, Laura Cracco, Gianfranco Puoti, Thomas W. Prior, Mark L. Cohen, Steven J. Collins, Simon Mead, Brian S. Appleby
Publikováno v:
Viruses, Vol 13, Iss 9, p 1794 (2021)
Genetic prion disease accounts for 10–15% of prion disease. While insertion of four or more octapeptide repeats are clearly pathogenic, smaller repeat insertions have an unclear pathogenicity. The goal of this case series was to provide an insight
Externí odkaz:
https://doaj.org/article/c04a6d71b61f49a99831430bef4d4116
Autor:
Liane S. Canas, Carole H. Sudre, Enrico De Vita, Akin Nihat, Tze How Mok, Catherine F. Slattery, Ross W. Paterson, Alexander J.M. Foulkes, Harpreet Hyare, M. Jorge Cardoso, John Thornton, Jonathan M. Schott, Frederik Barkhof, John Collinge, Sébastien Ourselin, Simon Mead, Marc Modat
Publikováno v:
NeuroImage: Clinical, Vol 24, Iss , Pp - (2019)
Prion diseases are a group of rare neurodegenerative conditions characterised by a high rate of progression and highly heterogeneous phenotypes. Whilst the most common form of prion disease occurs sporadically (sporadic Creutzfeldt–Jakob disease, s
Externí odkaz:
https://doaj.org/article/7a1f7d14910546ba9474019266b13c9d
Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease
Autor:
Tze How Mok, Akin Nihat, Nour Majbour, Danielle Sequeira, Leah Holm-Mercer, Thomas Coysh, Lee Darwent, Mark Batchelor, Bradley R Groveman, Christina D Orr, Andrew G Hughson, Amanda Heslegrave, Rhiannon Laban, Elena Veleva, Ross W Paterson, Ashvini Keshavan, Jonathan M Schott, Imogen J Swift, Carolin Heller, Jonathan D Rohrer, Alexander Gerhard, Christopher Butler, James B Rowe, Mario Masellis, Miles Chapman, Michael P Lunn, Jan Bieschke, Graham S Jackson, Henrik Zetterberg, Byron Caughey, Peter Rudge, John Collinge, Simon Mead
Human prion diseases are remarkable for long incubation times followed typically by rapid clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are remarkably useful in the clinical phase, but their potential to predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01793c1b3a290902fc8ea00f8ec41a6a
https://www.repository.cam.ac.uk/handle/1810/350803
https://www.repository.cam.ac.uk/handle/1810/350803
Autor:
Tze How Mok, Akin Nihat, Nour Majbour, Danielle Sequeira, Leah Holm-Mercer, Thomas Coysh, Lee Darwent, Mark Batchelor, Bradley R Groveman, Christina D Orrù, Andrew G Hughson, Amanda Heslegrave, Rhiannon Laban, Elena Veleva, Ross W Paterson, Ashvini Keshavan, Jonathan Schott, Imogen J Swift, Carolin Heller, Jonathan D Rohrer, Alexander Gerhard, Christopher Butler, James B Rowe, Mario Masellis, Miles Chapman, Michael P Lunn, Jan Bieschke, Graham Jackson, Henrik Zetterberg, Byron Caughey, Peter Rudge, John Collinge, Simon Mead
Human prion diseases are remarkable for long incubation times followed by typically rapid clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are remarkably useful in the clinical phase, but their potential to predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da3aac789cb837499652c75f72d24073
https://doi.org/10.1101/2022.10.30.22281644
https://doi.org/10.1101/2022.10.30.22281644
Autor:
Mark Batchelor, Akin Nihat, Graham S. Jackson, Danielle Sequeira, Tze How Mok, John Collinge, Connie Luk, Simon Mead
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant t
Autor:
Tze How Mok, Simon Mead
Publikováno v:
Current Opinion in Neurobiology. 61:82-88
Therapeutic strategies and study designs for neurodegenerative diseases have started to explore the potential of preventive treatment in healthy people, emphasising characterisation of biomarkers capable of indicating proximity to clinical onset. Thi
Autor:
Akin Nihat, Tze How Mok, Hans Odd, Andrew Geoffrey Bourne Thompson, Diana Caine, Kirsty McNiven, Veronica O'Donnell, Selam Tesfamichael, Peter Rudge, John Collinge, Simon Mead
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 93(4)
ObjectiveTo use a robust statistical methodology to develop and validate clinical rating scales quantifying longitudinal motor and cognitive dysfunction in sporadic Creutzfeldt-Jakob disease (sCJD) at the bedside.MethodsRasch analysis was used to ite
Autor:
Danielle Sequeira, Aaron Jesuthasan, Harpreet Hyare, Hans Odd, Peter Rudge, Tze How Mok, Akin Nihat, John Collinge, Simon Mead
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:A101.2-A101
IntroductionMRI sensitivity of up to 96% for pre-mortem diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) has previously been reported. However, in 2012, Carswell et al. found that the initial neuroradio- logical report often failed to identify