Unique Allelic eQTL Clusters in Human MHC Haplotypes

Autor: Tze Hau Lam, Meixin Shen, Matthew Zirui Tay, Ee Chee Ren

Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2595-2604 (2017)

The control of gene regulation within the major histocompatibility complex (MHC) remains poorly understood, despite several expression quantitative trait loci (eQTL) studies revealing an association of MHC gene expression with independent tag-single

Externí odkaz: https://doaj.org/article/6bca2d0a10fd46deac2944d5b3362366

Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter

Autor: Hui Ling Ko, Tze Hau Lam, Huijin Ng, Jiaying Toh, Liang Wei Wang, Ee Chee Ren

Publikováno v: Journal of Hepatology. 68:42-52

Background & Aims The Hepatitis B Virus (HBV) may gain entry into non-liver cells but does not actively replicate in them. We investigated the possibility that these cells possess mechanisms that block HBV core promoter (HBVCP) transcription, specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c560db749085f19d8bdcfdfad32ce8ec
https://doi.org/10.1016/j.jhep.2017.08.033

Understanding the microbial basis of body odor in pre-pubescent children and teenagers

Autor: Jianjun Li, Tze Hau Lam, Ping Hu, Rong Kong, Jiquan Liu, Dan Schnell, Davide Verzotto, David Frederick Swaile, Jay P. Tiesman, Niranjan Nagarajan, Thi My Uyen Ton, Yang Lu, Amanda Hui Qi Ng, Purbita Brahma, May Ong, Ping Liu

Publikováno v: Microbiome 6 (2018). doi:10.1186/s40168-018-0588-z
info:cnr-pdr/source/autori:Lam T.H.; Verzotto D.; Brahma P.; Ng A.H.Q.; Hu P.; Schnell D.; Tiesman J.; Kong R.; Ton T.M.U.; Li J.; Ong M.; Lu Y.; Swaile D.; Liu P.; Liu J.; Nagarajan N./titolo:Understanding the microbial basis of body odor in pre-pubescent children and teenagers/doi:10.1186%2Fs40168-018-0588-z/rivista:Microbiome/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Microbiome
Microbiome, Vol 6, Iss 1, Pp 1-14 (2018)

Background Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it is believed to give rise to body odor in humans. While mechanisms of odor generation have been widely studied in adults, little is kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c32c16c42eb2fc5f078d82332e8917

Synthesis and potent cytotoxic activity of 8- and 9-anilinophenanthridine-7,10-diones

Autor: Tze Hau Lam, Paul H. Bernardo, Jasmeet K. Khanijou, Joo Chuan Tong, Christina L. L. Chai

Publikováno v: Tetrahedron Letters. 52:92-94

A series of 8-anilino and 9-anilinophenanthridine-7,10-diones was prepared and screened against various cancer cell lines to measure anti-proliferative activity. The compounds tested display potent cytotoxic activity in the micromolar and sub-micromo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3acade7126b3e562ef4d033c720f2d2
https://doi.org/10.1016/j.tetlet.2010.10.170

CLEVER: A general design tool for combinatorial libraries

Autor: Tze Hau, Lam, Paul H, Bernardo, Christina L L, Chai, Joo Chuan, Tong

Publikováno v: Methods in molecular biology (Clifton, N.J.). 685

CLEVER is a computational tool designed to support the creation, manipulation, enumeration, and visualization of combinatorial libraries. The system also provides a summary of the diversity, coverage, and distribution of selected compound collections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c273a27dfb8d0d5689d8bebfa9eb825
https://pubmed.ncbi.nlm.nih.gov/20981533