Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tze Chiun Lim"'
Publikováno v:
Experimental dermatologyREFERENCES. 30(5)
Publikováno v:
Acta Biomaterialia. 46:266-277
The use of human induced pluripotent stem cells (hiPSCs) for clinical tissue engineering applications requires expansion and differentiation of the cells using defined, xeno-free substrates. The screening and selection of suitable synthetic substrate
Autor:
Markus M. Nöthen, Bryan Siu Yin Ho, Michael P. Philpott, Axel M. Hillmer, Yee Yen Sia, Paul L. Bigliardi, Elaine G.Y. Chew, Stefanie Heilmann, Joanna H.J. Tan, Xingliang Liu, Andrew C.A. Wan, Tze Chiun Lim, Adiam W. Bahta
Publikováno v:
Journal of Investigative Dermatology. 136:1559-1567
Androgenetic alopecia (AGA) is a common heritable and androgen-dependent hair loss condition in men. Twelve genetic risk loci are known to date, but it is unclear which genes at these loci are relevant for AGA. Dermal papilla cells (DPCs) located in
Autor:
Chan Du, Hong Fang Lu, Meng Fatt Leong, Andrew C.A. Wan, Jia Kai Lim, Tze Chiun Lim, Ying Ping Chua
Publikováno v:
Biofabrication. 9(2)
Cardiotoxicity is one of the major reasons for clinical drug attrition. In vitro tissue models that can provide efficient and accurate drug toxicity screening are highly desired for preclinical drug development and personalized therapy. Here, we repo
Autor:
Andrew C.A. Wan, Hong Fang Lu, Jackie Y. Ying, Meng Fatt Leong, Shujun Gao, Tze Chiun Lim, Chan Du
Publikováno v:
Biomaterials. 34:7064-7072
The hair follicle is a regenerating organ that produces a new hair shaft during each growth cycle. Development and cycling of the hair follicle is governed by interactions between the epithelial and mesenchymal components. Therefore, development of a
Autor:
Deepak Raghothaman, Eng Hin Lee, Meng Fatt Leong, Zheng Ser, Andrew C.A. Wan, Tze Chiun Lim, Zheng Yang
Publikováno v:
Biomedical materials (Bristol, England). 11(2)
Repair of critical-size articular cartilage defects typically involves delivery of cells in biodegradable, 3D matrices. Differences in the developmental status of mesenchymal stem cells (MSCs) and terminally differentiated mature chondrocytes might b
Publikováno v:
Rapid Prototyping Journal. 14:246-253
PurposeThe purpose of this paper is to develop a new bio‐plotter using a rapid freeze prototyping (RFP) technique and to investigate its potential applications in fabricating tissue scaffolds.Design/methodology/approachThe development of cryogenic
Publikováno v:
Virtual and Physical Prototyping. 3:25-31
A major challenge in tissue engineering has been the creation of scaffolds with controlled complex geometries. Rapid prototyping (RP) has the ability to produce complex three-dimensional structures with precise control of pore size, geometry and conn
Autor:
Chou Chai, Hong Fang Lu, Tze Chiun Lim, Shujun Gao, Meng Fatt Leong, Andrew C.A. Wan, Jia Kai Lim, Kah-Leong Lim
Publikováno v:
Biomaterials. 35(9)
A defined xeno-free system for patient-specific iPSC derivation and differentiation is required for translation to clinical applications. However, standard somatic cell reprogramming protocols rely on using MEFs and xenogeneic medium, imposing a sign
Autor:
Andrew C.A. Wan, Tze Chiun Lim, Zheng Yang, Eng Hin Lee, Meng Fatt Leong, Jerry K. C. Toh, Deepak Raghothaman
Publikováno v:
Biomaterials. 35(9)
Cell-cell and cell-matrix interactions are important events in directing stem cell chondrogenesis, which can be promoted in matrix microenvironments presenting appropriate ligands. In this study, interfacial polyelectrolyte complexation (IPC) based h