Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages

Autor: Tzanko S. Stantchev, Autumn Zack-Taylor, Nicholas Mattson, Klaus Strebel, Christopher C. Broder, Kathleen A. Clouse

Publikováno v: Viruses, Vol 11, Iss 10, p 889 (2019)

Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to in

Externí odkaz: https://doaj.org/article/ce7db01973744e66ab00ae78a2ea6111

Cell Adhesion Promotes Ebola Virus Envelope Glycoprotein-Mediated Binding and Infection

Autor: Matthew I. Bonaparte, Tzanko S. Stantchev, Christopher C. Broder, Sue E. Delos, Judith M. White, Derek Dube, Amy H. Bouton, Kathryn L. Schornberg

Publikováno v: Journal of Virology. 82:7238-7242

Ebola virus infects a wide variety of adherent cell types, while nonadherent cells are found to be refractory. To explore this correlation, we compared the ability of pairs of related adherent and nonadherent cells to bind a recombinant Ebola virus r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43784f1d79626bf811141ae477600c3d
https://doi.org/10.1128/jvi.00425-08

Human immunodeficiency virus type-1 and chemokines: beyond competition for common cellular receptors

Autor: Tzanko S. Stantchev, Christopher C. Broder

Publikováno v: Cytokine & Growth Factor Reviews. 12:219-243

The chemokines and their receptors have been receiving exceptional attention in recent years following the discoveries that some chemokines could specifically block human immunodeficiency virus type 1 (HIV-1) infection and that certain chemokine rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3c4bc71f8dc1dabb1687749244fd8d
https://doi.org/10.1016/s1359-6101(00)00033-2

A Mechanism of Resistance to HIV-1 Entry: Inefficient Interactions of CXCR4 with CD4 and gp120 in Macrophages

Autor: Dimiter S. Dimitrov, Yan-Ru Feng, David Norwood, Xiaodong Xiao, Tzanko S. Stantchev, Christopher C. Broder

Publikováno v: Virology. 259(1):1-6

To test the hypothesis that inefficient interactions of CXCR4 with CD4 and gp120 could affect HIV-1 entry, we incubated macrophages, monocytes, and lymphocytes with gp120 and coimmunoprecipitated CD4 by using anti-CXCR4 antibodies. CD4 was efficientl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803609f2e5382687b52e8d61e2086fb1

Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection

Autor: Bharat Khurana, Prasun K Moitra, Mary Lou Cutler, Lei Zhuang, Tzanko S. Stantchev, Peter D'Arpa, Christopher C. Broder

Publikováno v: Khurana, Bharat; Zhuang, Lei; Moitra, Prasun K; Stantchev, Tzanko S; Broder, Christopher C; Cutler, Mary Lou; D'Arpa, Peter (2010). Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection. Virology journal, 7, p. 332. London: BioMed Central 10.1186/1743-422X-7-332
Virology Journal, Vol 7, Iss 1, p 332 (2010)
Virology Journal

Background Host determinants of HIV-1 viral tropism include factors from producer cells that affect the efficiency of productive infection and factors in target cells that block infection after viral entry. TRIM5α restricts HIV-1 infection at an ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cdc6243347ae6350d7d60eeae2a1a4
https://doi.org/10.1186/1743-422x-7-332