Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Tyzoon K. Nomanbhoy"'
Autor:
Tsuyoshi Imasaki, Patrick Baumann, Claudine Bisson, Ashish Radadiya, Yuichiro Takagi, David W. Rice, Svetlana E. Sedelnikova, Nigel G. J. Richards, Adriana Coricello, Tyzoon K. Nomanbhoy, Alexandria H. Berry, Sabine Wenzel, John W. Kozarich, Yi Jin, Brian E. Nordin, Wen Zhu, Francisco Martínez-Márquez
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Communications Biology
Communications Biology
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a bona fide drug
Autor:
Tyzoon K. Nomanbhoy, Sabine Wenzel, Alexandria H. Berry, Brian E. Nordin, Nigel G. J. Richards, Tsuyoshi Imasaki, David W. Rice, Claudine Bisson, Wen Zhu, Francisco Martínez-Márquez, Adriana Coricello, Patrick Baumann, Yuichiro Takagi, Ashish Radadiya, John W. Kozarich, Svetlana E. Sedelnikova, Yi Jin
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-1 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-1 (2019)
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a
Autor:
Zinan Zhang, Myriam Boukhali, Zainab M. Doctor, Jennifer L. Green, Calla M. Olson, James E. Bradner, Richard A. Young, Nathanael S. Gray, Nicholas Kwiatkowski, Eric S. Fischer, Tinghu Zhang, Wilhelm Haas, Baishan Jiang, Tyzoon K. Nomanbhoy, Georg E. Winter, Michael A. Erb, Yanke Liang
Publikováno v:
Nature Chemical Biology. 14:163-170
Cyclin dependent kinase 9 (CDK9), a key regulator of transcriptional elongation, is a promising target for cancer therapy, particularly for cancers driven by transcriptional dysregulation. Here, we report the characterization of NVP-2 (3), a selectiv
Autor:
Kevin B. Dagbay, Tyzoon K. Nomanbhoy, John W. Kozarich, Jennifer L. Green, Eric Okerberg, Sergey N. Savinov, Ishankumar V Soni, Arwin Aban, Jeanne A. Hardy
Publikováno v:
Biochemistry. 58(52)
Acyl phosphates of ATP (ATPAc) and related nucleotides have proven to be useful for the interrogation of known nucleotide binding sites via specific acylation of conserved lysines (K). In addition, occasional K acylations are identified in proteins w
Autor:
Senait Alemayehu, Jonathan S. Rosenblum, Geeta Sharma, Tyzoon K. Nomanbhoy, Arwin Aban, Maria Sykes, John W. Kozarich, Subha Vogeti, Jiangyue Wu, Heidi E. Brown
Publikováno v:
Biochemistry. 55:5434-5441
Palbociclib is a cyclin-dependent kinase (CDK) 4/CDK6 inhibitor approved for breast cancer that is estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative. We profiled palbociclib in cells either sensitive or resi
Autor:
Wen Zhu, Brian E. Nordin, John W. Kozarich, David W. Rice, Yi Jin, Svetlana E. Sedelnikova, Nigel G. J. Richards, Yuichiro Takagi, Sabine Wenzel, Claudine Bisson, Ashish Radadiya, Alexandria H. Berry, Patrick Baumann, Tsuyoshi Imasaki, Tyzoon K. Nomanbhoy
Expression of the enzyme human asparagine synthetase (ASNS) promotes metastatic progression in breast cancer, which affects L-asparagine levels and tumor cell invasiveness. Human ASNS has therefore emerged as abona fidedrug target for cancer therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278fe1ec095c7d5883329324ce978eb5
Autor:
Jiangyue Wu, Laia Monserrat, Violeta Serra, Josilyn Sejd, Marta Palafox, Senait Alemayehu, Jennifer L. Green, Eric Okerberg, Arwin Aban, Tyzoon K. Nomanbhoy, Maria Sykes
Publikováno v:
Molecular cancer therapeutics. 18(4)
The interaction of a drug with its target is critical to achieve drug efficacy. In cases where cellular environment influences target engagement, differences between individuals and cell types present a challenge for a priori prediction of drug effic
Autor:
Helge Weissig, Shyama Sidique, John W. Kozarich, Emme C.K. Lin, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Junichi Ishiyama, Yi Hu, Bei Li, Christopher M. Amantea
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0e539b27866c3e1d8419d25b4f8e3
https://europepmc.org/articles/PMC5081620/
https://europepmc.org/articles/PMC5081620/
Autor:
Helge Weissig, Bei Li, Junichi Ishiyama, Yi Hu, Shyama Sidique, Tyzoon K. Nomanbhoy, Jonathan S. Rosenblum, Emme C.K. Lin, Christopher A. Amantea, John W. Kozarich
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal and tissue-restricted delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49cdb1aa5edb36cb53312a114b6d1f
https://doi.org/10.1101/038513
https://doi.org/10.1101/038513
Autor:
Jennifer R. Chapman, Tyzoon K. Nomanbhoy, Matthew P. Patricelli, Hwan Geun Choi, Elena M. Cortizas, John Matthews, Nathanael S. Gray, Dita Gratzinger, Robert Tibshirani, Daxing Zhu, Ramiro E. Verdun, Ragini Shyam, Ranjana H. Advani, Jianming Zhang, Li Tan, Andrew J. Gentles, Yasodha Natkunam, Ezequiel Martinez, Xiaoyu Jiang, Sara J. Buhrlage, Izidore S. Lossos, Shruti Bhatt, Shideh Chinichian
Publikováno v:
Blood. 128(2)
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, yet 40% to 50% of patients will eventually succumb to their disease, demonstrating a pressing need for novel therapeutic options. Gene expression profiling has