Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Tyuji, Hoshino"'
Publikováno v:
Chemical and Pharmaceutical Bulletin. 71:360-367
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807871a03c263ff8f38b01dcf8d675f7
https://doi.org/10.1248/cpb.c23-00035
https://doi.org/10.1248/cpb.c23-00035
Publikováno v:
Materials & Design, Vol 199, Iss , Pp 109429- (2021)
Fatty acid-based in situ forming systems that carry vancomycin HCl (VCM) have been developed to treat local Gram-positive infections. However, little is known about mechanistic formation of fat-based in situ forming matrices. In this study, VCM-loade
Externí odkaz:
https://doaj.org/article/1a07d0e2368f4068abcdaa8e74a08dcb
Autor:
Barbara Herlah, Andrej Hoivik, Luka Jamšek, Katja Valjavec, Norio Yamamoto, Tyuji Hoshino, Krištof Kranjc, Andrej Perdih
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 539 (2022)
The emergence of SARS-CoV-2, responsible for the global COVID-19 pandemic, requires the rapid development of novel antiviral drugs that would contribute to an effective treatment alongside vaccines. Drug repurposing and development of new molecules t
Externí odkaz:
https://doaj.org/article/8d0e56a5c12d46d488d1637e278c88c0
Autor:
Yan Guo, Tyuji Hoshino
Publikováno v:
Crystal Growth & Design. 22:6751-6765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e92553ece28a85292439b613dffeba9
https://doi.org/10.1021/acs.cgd.2c00901
https://doi.org/10.1021/acs.cgd.2c00901
Publikováno v:
Journal of Chemical Information and Modeling. 62:6762-6774
Chemotherapy of human immunodeficiency virus type-1 (HIV-1) has significantly developed over the last three decades. The emergence of drug-resistant variants is, however, still a severe problem. The RNase H activity of HIV-1 reverse transcriptase is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2278e83bcefd72c90394d1aaefd5c6
https://doi.org/10.1021/acs.jcim.2c00537
https://doi.org/10.1021/acs.jcim.2c00537
Autor:
Michiyoshi Nukaga, Tyuji Hoshino, Akiko Takaya, Taichi Kamo, Keiichi Kuroda, Tomoki Yoneda, Usaki Hayashi, Shota Kondo, Satoshi Fudo
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:1179-1183
Metallo-beta-lactamases (MBLs) are significant threats to humans because they deteriorate many kinds of beta-lactam antibiotics and are key enzymes responsible for multi-drug resistance of bacterial pathogens. As a result of in vitro screening, two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338177d891375c86816ac2547f371d74
https://doi.org/10.1248/cpb.c21-00611
https://doi.org/10.1248/cpb.c21-00611
Autor:
Mizuna, Takahashi, Takahiro, Tsuchikawa, Takaki, Hiwasa, Toru, Nakamura, Koji, Hontani, Toshihiro, Kushibiki, Kazuho, Inoko, Hironobu, Takano, Yutaka, Hatanaka, Kazuyuki, Matsushita, Hisahiro, Matsubara, Tyuji, Hoshino, Masayuki, Ohtsuka, Hideaki, Shimada, Kimitaka, Tanaka, Yoshitsugu, Nakanishi, Toshimichi, Asano, Takehiro, Noji, Keisuke, Okamura, Toshiaki, Shichinohe, Satoshi, Hirano
Publikováno v:
Oncology Reports. 49
Biliary cancer has a poor prognosis due to a lack of specific biomarkers and difficulty in diagnosis. The present study aimed to identify serum tumor markers for the diagnosis of biliary cancer via serological identification of antigens by recombinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2521318301a1f847d8803c6df4fa69e2
https://doi.org/10.3892/or.2022.8471
https://doi.org/10.3892/or.2022.8471
Autor:
Kouichi Kitamura, Tyuji Hoshino, Atsushi Okabe, Masaki Fukuyo, Bahityar Rahmutulla, Nobuko Tanaka, Sohei Kobayashi, Tomoaki Tanaka, Takashi Shida, Mashiro Ueda, Toshinari Minamoto, Hisahiro Matsubara, Atsushi Kaneda, Kazuyuki Matsushita
This study indicated the novel impaired mechanism of ribosomal RNA (rRNA) transcription that causes cancer development. Human transcription factor IIH (TFIIH) is an essential factor with a seven-subunit core, including the P62 subunit, and is pivotal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3825fb7d2b2a7d5c152e21cee672fdf5
https://doi.org/10.21203/rs.3.rs-1722555/v2
https://doi.org/10.21203/rs.3.rs-1722555/v2
Publikováno v:
Journal of Chemical Information and Modeling. 61:2396-2406
Antibodies are one of the most important protein molecules in biopharmaceutics. Due to the recent advance in technology for producing monoclonal antibodies, many structural data are available on the antigen-antibody complexes. To characterize the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9758b9f9b16be66afb5b3c3186de5c
https://doi.org/10.1021/acs.jcim.1c00167
https://doi.org/10.1021/acs.jcim.1c00167
Autor:
Michael J Yoon, Elise T. Zeiser, Joseph R Johnson, Magdalena A Taracilia, Scott A. Becka, Krisztina M. Papp-Wallace, Michiyoshi Nukaga, Tyuji Hoshino
Publikováno v:
ACS Infectious Diseases. 7:826-837
Burkholderia cepacia complex (Bcc) poses a serious health threat to people with cystic fibrosis or compromised immune systems. Infections often arise from Bcc strains, which are highly resistant to many classes of antibiotics, including β-lactams.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f20e7c8bf17760c108a89e830b5bafe
https://doi.org/10.1021/acsinfecdis.0c00682
https://doi.org/10.1021/acsinfecdis.0c00682