Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Tyson V"'
Autor:
Dani Dumitriu, Andréane Lavallée, Jessica L. Riggs, Cynthia A. Frosch, Tyson V. Barker, Debra L. Best, Brenda Blasingame, Jessica Bushar, Dominique Charlot-Swilley, Elizabeth Erickson, Morgan A. Finkel, Bryn Fortune, Leah Gillen, Marty Martinez, Usha Ramachandran, Lee M. Sanders, David W. Willis, Nikki Shearman
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Here, we introduce the Early Relational Health (ERH) Learning Community's bold, large-scale, collaborative, data-driven and practice-informed research agenda focused on furthering our mechanistic understanding of ERH and identifying feasible and effe
Externí odkaz:
https://doaj.org/article/3fd62bed61744b56b45d374077fde46c
Autor:
Kathryn Davidson, Paul Grevitt, Maria F. Contreras-Gerenas, Katherine S. Bridge, Miguel Hermida, Kunal M. Shah, Faraz K. Mardakheh, Mark Stubbs, Rosemary Burke, Pedro Casado, Pedro R. Cutillas, Sarah A. Martin, Tyson V. Sharp
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which suppresses tumorigenesis via a number of different mechanisms. Approximately 45% of non-small c
Externí odkaz:
https://doaj.org/article/006a5cc989ef440e83fa93a4ded65708
Autor:
Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Externí odkaz:
https://doaj.org/article/3c3cfae19b254f35bbc5345f4b26032c
Autor:
Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting‐Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei‐Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala‐Dilke, Ian Spendlove, Tyson V Sharp
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp 1-18 (2018)
Abstract The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β subunits. Prolonged HIF expression is a key contri
Externí odkaz:
https://doaj.org/article/9b04680e29334b599d9575042b42aeeb
Autor:
Duncan C. Miller, Stephen C. Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C. Edwards, James S. Ware, Tyson V. Sharp, Tristan R. McKay, Leo Dunkel, Pier D. Lambiase, Andrew Tinker
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 233-244 (2017)
The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode of action in human induced pl
Externí odkaz:
https://doaj.org/article/ca9d87c0e4fa49e08673fd8726d3486f
Autor:
George A. Buzzell, John E. Richards, Lauren K. White, Tyson V. Barker, Daniel S. Pine, Nathan A. Fox
Publikováno v:
NeuroImage, Vol 157, Iss , Pp 13-26 (2017)
The ability to self-detect errors and dynamically adapt behavior is a cornerstone of higher-level cognition, requiring coordinated activity from a network of neural regions. However, disagreement exists over how the error-monitoring system develops t
Externí odkaz:
https://doaj.org/article/193d3956a05d4b7f9dadae33c2278028
Autor:
Katherine S. Bridge, Kunal M. Shah, Yigen Li, Daniel E. Foxler, Sybil C.K. Wong, Duncan C. Miller, Kathryn M. Davidson, John G. Foster, Ruth Rose, Michael R. Hodgkinson, Paulo S. Ribeiro, A. Aziz Aboobaker, Kenta Yashiro, Xiaozhong Wang, Paul R. Graves, Michael J. Plevin, Dimitris Lagos, Tyson V. Sharp
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 173-187 (2017)
As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assemb
Externí odkaz:
https://doaj.org/article/dd86764956e7461fbbd192078a7216b7
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80470 (2013)
TNF receptor-associated factors (TRAFs) are multifunctional adaptor proteins involved in temporal and spatial coordination of signals necessary for normal immune function. Here, we report that TRAF3, a TRAF family member with a key role in Toll-like
Externí odkaz:
https://doaj.org/article/bfa6dd80fe3247e9a1d816bbb0458385
Autor:
Cristina González-Estévez, Daniel A Felix, Matthew D Smith, Jordi Paps, Simon J Morley, Victoria James, Tyson V Sharp, A Aziz Aboobaker
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002619 (2012)
Planarian flatworms are able to both regenerate their whole bodies and continuously adapt their size to nutrient status. Tight control of stem cell proliferation and differentiation during these processes is the key feature of planarian biology. Here
Externí odkaz:
https://doaj.org/article/bf3c1da8bcdb470b8094fc4192252b8e