Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tysheena P. Charles"'
Autor:
Venkata S. Bollimpelli, Pradeep B. J Reddy, Sailaja Gangadhara, Tysheena P. Charles, Samantha L. Burton, Gregory K. Tharp, Tiffany M. Styles, Celia C. Labranche, Justin C. Smith, Amit A. Upadhyay, Anusmita Sahoo, Traci Legere, Ayalnesh Shiferaw, Vijayakumar Velu, Tianwei Yu, Mark Tomai, John Vasilakos, Sudhir P. Kasturi, George M. Shaw, David Montefiori, Steven E. Bosinger, Pamela A. Kozlowski, Bali Pulendran, Cynthia A. Derdeyn, Eric Hunter, Rama R. Amara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2
Externí odkaz:
https://doaj.org/article/101d7faa095245b791894f88734b70d5
Autor:
Tysheena P Charles, Samantha L Burton, Prabhu S Arunachalam, Christopher A Cottrell, Leigh M Sewall, Venkata S Bollimpelli, Sailaja Gangadhara, Antu K Dey, Andrew B Ward, George M Shaw, Eric Hunter, Rama R Amara, Bali Pulendran, Marit J van Gils, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009257 (2021)
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robus
Externí odkaz:
https://doaj.org/article/9eebb505e6de4f35a7e3bc5ad081b207
Autor:
Daniel L. Moss, Samuel J. Landry, Kummer A Nicholas, Tysheena P. Charles, Pawan Bhat, Avik Bhattacharya, Ramgopal R. Mettu, Peyton W Moore
Publikováno v:
Biochemistry. 61:1585-1599
Antigen processing in the class II MHC pathway depends on conventional proteolytic enzymes, potentially acting on antigens in native-like conformational states. CD4+ epitope dominance arises from a competition between antigen folding, proteolysis, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fd1ddf983f30c6a16cb92459280f0f
https://doi.org/10.1021/acs.biochem.2c00237
https://doi.org/10.1021/acs.biochem.2c00237
Autor:
Min Gu, Derrick R. Samuelson, Nicholas M. de la Rua, Tysheena P. Charles, Christopher M. Taylor, Meng Luo, Robert W. Siggins, Judd E. Shellito, David A. Welsh
Publikováno v:
Microbiol Immunol
The gut microbiota has a fundamental role in the development and the maturation of the host immune system. Both innate and adaptive immune cells have critical functions in microbial pathogen containment and clearance, but the regulation of the commen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d0113be1d50d510f838829c2dddfec
https://doi.org/10.1111/1348-0421.12963
https://doi.org/10.1111/1348-0421.12963
Autor:
Nicholas M de la Rua, Derrick Richard Samuelson, Tysheena P Charles, David Allen Welsh, Judd E. Shellito
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Pneumocystis pneumonia is a major cause of morbidity and mortality among immunocompromised patients, especially in the context of HIV/AIDS. In the murine model of Pneumocystis pneumonia, CD4+ T-cells are required for clearance of a primary infection
Externí odkaz:
https://doaj.org/article/c6705c2cbddb4e6f846328e546355e3b
Autor:
Traci Legere, Pradeep B. J. Reddy, Korey A. Walter, Bali Pulendran, Prabhu S. Arunachalam, Shankar Subramaniam, Florian Wimmers, Madeleine K D Scott, Celia C. LaBranche, Bertrand Z. Yeung, John P. Vasilakos, Venkata S. Bollimpelli, Samantha L. Burton, Sailaja Gangadhara, Sudhir Pai Kasturi, Shakti Gupta, Cynthia A. Derdeyn, Caroline Petitdemange, Pamela A. Kozlowski, David C. Montefiori, Tiffany M. Styles, Thomas J. Ketas, John P. Moore, Chil Yong Kang, Rama Rao Amara, Eric Hunter, George M. Shaw, Purvesh Khatri, Mark A. Tomai, Anthony Tsai, David Masopust, Vineet Joag, Clare F. Quarnstrom, Tysheena P. Charles
Publikováno v:
Nature Medicine
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad3f6afa379c5c408d930aefb7aaee
https://doi.org/10.1038/s41591-020-0858-8
https://doi.org/10.1038/s41591-020-0858-8
Publikováno v:
The Journal of clinical investigation. 129(11)
HVTN 505 is a preventative vaccine efficacy trial testing DNA followed by recombinant adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and transgendered persons who have sex with men in the United States. Identified immune correlates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7891aef53256abce84fd2edcf5dd934d
https://pubmed.ncbi.nlm.nih.gov/31589165
https://pubmed.ncbi.nlm.nih.gov/31589165
Autor:
Christopher A. Cottrell, Eric Hunter, L.M. Sewall, Venkata S. Bollimpelli, Prabhu S. Arunachalam, Tysheena P. Charles, Cynthia A. Derdeyn, Rama Rao Amara, Sailaja Gangadhara, Marit J. van Gils, Samantha L. Burton, George M. Shaw, Andrew B. Ward, Antu K. Dey, Bali Pulendran
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009257 (2021)
PLoS Pathogens
PLoS pathogens, 17(2):e1009257. Public Library of Science
PLoS Pathogens
PLoS pathogens, 17(2):e1009257. Public Library of Science
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d5aae89199ec88663ec2eec961cdb7
https://doi.org/10.1371/journal.ppat.1009257
https://doi.org/10.1371/journal.ppat.1009257
Autor:
Judd E. Shellito, David A. Welsh, Christopher M. Taylor, Meng Luo, Derrick R. Samuelson, Eugene Blanchard, Tysheena P. Charles, Nicholas M. de la Rua
Publikováno v:
Experimental Lung Research. 42:425-439
Pneumocystis pneumonia is a major cause of morbidity and mortality in patients infected with HIV/AIDS. In this study, we evaluated the intestinal microbial communities associated with the development of experimental Pneumocystis pneumonia, as there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcf1c321e0ae8d8d9c0431fb2bbdea8
https://doi.org/10.1080/01902148.2016.1258442
https://doi.org/10.1080/01902148.2016.1258442
Publikováno v:
Journal of Immunological Methods. 432:72-81
T-cell CD4+ epitopes are important targets of immunity against infectious diseases and cancer. State-of-the-art methods for MHC class II epitope prediction rely on supervised learning methods in which an implicit or explicit model of sequence specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dd937f477525f9aaa166f903073eed
https://doi.org/10.1016/j.jim.2016.02.013
https://doi.org/10.1016/j.jim.2016.02.013