Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Tyrza van Leeuwen"'
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Akademický článek
Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron Microscopy
Autor: Floris J. van Dalen, Thomas Bakkum, Tyrza van Leeuwen, Mirjam Groenewold, Edgar Deu, Abraham J. Koster, Sander I. van Kasteren, Martijn Verdoes
Publikováno v: Frontiers in Chemistry, Vol 8 (2021)
Cathepsin S is a lysosomal cysteine protease highly expressed in immune cells such as dendritic cells, B cells and macrophages. Its functions include extracellular matrix breakdown and cleavage of cell adhesion molecules to facilitate immune cell mot
Externí odkaz: https://doaj.org/article/0e57f5aafb46434b937c798381c0488d
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3
Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ
Autor: Diana Torres-García, Merel A. T. van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G. J. Groenewold, Alexi J. C. Sarris, Luuk Klein, Herman S. Overkleeft, Sander I. van Kasteren
Publikováno v: RSC Chemical Biology, 3(11), 1325-1330. ROYAL SOC CHEMISTRY
Bioorthogonal chemistry combines well with activity-based protein profiling, as it allows for the introduction of detection tags without significantly influencing the physiochemical and biological functions of the probe. In this work, we introduced m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0bda1d05d8c8f55b116c8859d7773c
http://hdl.handle.net/1887/3497774
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4
Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens
Autor: Can Araman, Mikkel H. S. Marqvorsen, René E. M. Toes, Marcel Camps, George M.C. Janssen, Ferry Ossendorp, Clarissa R. Nascimento, Gerard J. P. van Westen, Willemijn van der Wulp, G. J. Mirjam Groenewold, Arieke S. B. Kampstra, Thomas Bakkum, Tyrza van Leeuwen, Antonius P A Janssen, Herman S. Overkleeft, Peter A. van Veelen, Sander I. van Kasteren, Bogdan I. Florea, Linda Pieper Pournara
Publikováno v: RSC Chemical Biology, 2(3), 855-862. Royal Society of Chemistry ({RSC})
Rsc Chemical Biology
RSC Chemical Biology, 2(3), 855-862. ROYAL SOC CHEMISTRY
RSC Chemical Biology
Proteolysis is fundamental to many biological processes. In the immune system, it underpins the activation of the adaptive immune response: degradation of antigenic material into short peptides and presentation thereof on major histocompatibility com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba3d5912bbcee81d239494de3691466
https://hdl.handle.net/1887/3192759
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5
Application of a highly selective Cathepsin S two-step activity-based probe in multicolor bio-orthogonal correlative light-electron microscopy
Autor: Sander I. van Kasteren, Thomas Bakkum, Floris J. van Dalen, Tyrza van Leeuwen, Edgar Deu, Mirjam Groenewold, Martijn Verdoes, Abraham J. Koster
Publikováno v: Frontiers in Chemistry, 8. FRONTIERS MEDIA SA
Frontiers in Chemistry, 8, 628433
Frontiers in Chemistry, Vol 8 (2021)
Frontiers in Chemistry, 8
Frontiers in Chemistry
Thomas Bakkum
Cathepsin S is a lysosomal cysteine protease highly expressed in immune cells such as dendritic cells, B cells and macrophages. Its functions include extracellular matrix breakdown and cleavage of cell adhesion molecules to facilitate immune cell mot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136c938f05f4c28d223608888eebfc33
https://doi.org/10.3389/fchem.2020.628433
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6
Bioorthogonal correlative light-electron microscopy of mycobacterium tuberculosis in macrophages reveals the effect of antituberculosis drugs on subcellular bacterial distribution
Autor: Mirjam Groenewold, Mariëlle C. Haks, Thomas Bakkum, Martijn J.C. van der Lienden, Suzanne C. van Veen, Tom H. M. Ottenhoff, Kimberley V. Walburg, Nikolaos Oikonomeas-Koppasis, Erik Bos, Abraham J. Koster, Matthias T. Heemskerk, Tyrza van Leeuwen, Sander I. van Kasteren
Publikováno v: ACS Central Science
ACS Central Science, 6(11), 1997-2007. AMER CHEMICAL SOC
ACS Central Science, Vol 6, Iss 11, Pp 1997-2007 (2020)
Bioorthogonal correlative light-electron microscopy (B-CLEM) can give a detailed overview of multicomponent biological systems. It can provide information on the ultrastructural context of bioorthogonal handles and other fluorescent signals, as well
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7fbcee29f2d13994997387ad518859
https://hdl.handle.net/1887/3184855
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7
Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes
Autor: Thomas Bakkum, Alexi J. C. Sarris, Dimitrios Poulcharidis, Herman S. Overkleeft, Daphne M. van Elsland, Tyrza van Leeuwen, Sander I. van Kasteren
Publikováno v: ACS Chemical Biology
ACS Chemical Biology, 13(5), 1173-1179
One of the areas in which bioorthogonal chemistry-chemistry performed inside a cell or organism-has become of pivotal importance is in the study of host-pathogen interactions. The incorporation of bioorthogonal groups into the cell wall or proteome o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559a74515ca78009adf04743f33eb87d
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