Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tyrrell Norris"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59429 (2013)
The γ-aminobutyric acid A (GABA(A)) ion channels are important drug targets for treatment of neurological and psychiatric disorders. Finding GABA(A) channel subtype selective allosteric modulators could lead to new improved treatments. However, the
Externí odkaz:
https://doaj.org/article/85e7da534be14af897f32604d7d63b3d
Autor:
Catherine Bardelle, Rob Howes, Roger Clark, Mark Wigglesworth, Mei Ding, Wendy Williams, Tyrrell Norris, Anna Backmark
Publikováno v:
SLAS Discovery. 23:719-731
Flow cytometry is a powerful tool providing multiparametric analysis of single cells or particles. The introduction of faster plate-based sampling technologies on flow cytometers has transformed the technology into one that has become attractive for
Autor:
Fanny Langlet, Christoph Buettner, Daniel Lindén, Kumiko S. Aizawa, Domenico Accili, Ling Wang, Rebecca A. Haeusler, Elke Ericson, Anders Johansson, Joshua R. Cook, Tyrrell Norris
Publikováno v:
Cell. 171:824-835.e18
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight c
Autor:
Michael W. Wood, Rita Raddatz, Alan J. Cross, Richard C. Hastings, Shigeru Tanaka, Erik Ryberg, Norio Sakai, James Bostwick, Peter J. Greasley, Tyrrell Norris
Publikováno v:
The FASEB Journal. 28
GPR6 is a Class A G protein-coupled receptor and a member of a highly related subset that includes GPR3 and GPR12. Although GPR6 is a constitutively-active orphan GPCR, it has been reported that some signaling activity may be enhanced by lipids. Foll
Autor:
Naomi J. Logsdon, Clay W Scott, Alexander Graham, Tyrrell Norris, Cindy Sobotka-Briner, Stephen J. Hubbs, Deidre E. Wilkins
Publikováno v:
Cytokine. 12:858-866
The functional IL-5 receptor is a heteromeric complex consisting of an alpha and beta subunit. The cloning, sequencing and expression of guinea-pig IL-5Ralpha and beta subunits is described. The guinea-pig IL-5Ralpha subunit cDNA encodes a protein of
Autor:
Ann W. Fieles, Michel Goedert, Tyrrell Norris, Virginia M.-Y. Lee, Claudia B. Caputo, Clay W Scott, Mathew M.S. Lo, Pauline G. Dargis
Publikováno v:
Brain research. Molecular brain research. 20(3)
Tau protein is a neuronal microtubule-associated protein that promotes the assembly and stability of microtubules. To evaluate the biological significance of tau isoform diversity, NIH-3T3 cells were stably transfected with cDNAs encoding each of the
Publikováno v:
Journal of neuroscience research. 33(1)
Expression of tau protein in non-neuronal cells can result in a redistribution of the microtubule cytoskeleton into thick bundles of tau-containing microtubules (Lewis et al.: Nature 342:498-505, 1989; Kanai et al.: J Cell Biol 109:1173-1184, 1989).