Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Tyrosine protein kinase (Tyrosine kinase)"'
Publikováno v:
The Journal of Biological Chemistry
The nonreceptor protein tyrosine kinase Fyn and protein Ser/Thr phosphatase 2A (PP2A) are major multifunctional signaling molecules. Deregulation of Fyn and altered PP2A methylation are implicated in cancer and Alzheimer's disease (AD). Here, we test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dc235bb9757b5a3d752f93788ff7e8
https://pubmed.ncbi.nlm.nih.gov/33380425
https://pubmed.ncbi.nlm.nih.gov/33380425
Autor:
Chakroborty, D. (Deepankar), Kurppa, K. J. (Kari J.), Paatero, I. (Ilkka), Ojala, V. K. (Veera K.), Koivu, M. (Marika), Tamirat, M. Z. (Mahlet Z.), Koivunen, J. P. (Jussi P.), Jänne, P. A. (Pasi A.), Johnson, M. S. (Mark S.), Elo, L. L. (Laura L.), Elenius, K. (Klaus)
Cancer tissues harbor thousands of mutations, and a given oncogene may be mutated at hundreds of sites, yet only a few of these mutations have been functionally tested. Here, we describe an unbiased platform for the functional characterization of tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::423369ba2e53263180ddb05b27e01fdd
http://urn.fi/urn:nbn:fi-fe202003097621
http://urn.fi/urn:nbn:fi-fe202003097621
Publikováno v:
The Journal of Biological Chemistry
Cdc42 is a Rho-family small G protein that has been widely studied for its role in controlling the actin cytoskeleton and plays a part in several potentially oncogenic signaling networks. Similar to most other small G proteins, Cdc42 binds to many do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31521ae3b4bed12d3c3b80a8cc44b1e7
https://www.repository.cam.ac.uk/handle/1810/264658
https://www.repository.cam.ac.uk/handle/1810/264658
Autor:
Bernhard Nieswandt, Ying-Jie Wang, Steve P. Watson, Dylan M. Owen, Craig E. Hughes, Leyre Navarro-Núñez, David A. Jackson, Michael L. Dustin, Natalie S. Poulter, Eelo Gitz, Michael R. Douglas, Alice Y. Pollitt, Steven G. Thomas
Publikováno v:
The Journal of Biological Chemistry
Background: The interaction of platelet CLEC-2 with Podoplanin is critical for development of the lymphatics. Results: CLEC-2 forms a central cluster upon engagement with Podoplanin, which clusters Podoplanin. Clustering is dependent on Syk and is cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8cb6bf2688a85fac3da1e893a80e28
https://doi.org/10.1074/jbc.m114.584284
https://doi.org/10.1074/jbc.m114.584284
Autor:
Yuichi Sekine, Misa Nakasuji, Osamu Ikeda, Asuka Nanbo, Tadashi Matsuda, Akihiro Mizushima, Kenji Oritani, Yuto Miyasaka, Akihiko Yoshimura, Chikako Yamamoto, Ryuta Muromoto
Publikováno v:
Journal of Biological Chemistry. 285:38093-38103
Signal transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein, which contains pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, as well as a signal transducer and an activator of transcription 3 (STAT3)-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084134c2d2bf7ba39205f3567703537a
https://doi.org/10.1074/jbc.m110.162388
https://doi.org/10.1074/jbc.m110.162388
Autor:
Partha S. Mitra, Sunit K. Chakraborty, Nikhil K. Basu, Ida S. Owens, Tapas Saha, Mousumi Basu
Publikováno v:
The Journal of Biological Chemistry
Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in different tissues, it preferentially detoxifies genotoxic 4-OH-estradiol and 4-OH-estrone (4-OHE(1)) with barely detectable 17β-estradiol (E(2)) conversion following expression in COS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02dfcd1ecbaa88ba34e73540b707930
http://europepmc.org/articles/PMC3020772
http://europepmc.org/articles/PMC3020772
Autor:
Jean-Christophe Renauld, Elisabetta Flex, Sandrine Degryse, Jan Cools, Laurent Knoops, Tekla Hornakova, Marco Tartaglia, Elisabeth Losdyck, Stefan N. Constantinescu, Olga Gielen, Lorraine Springuel
Publikováno v:
Journal of Biological Chemistry, Vol. 290, no. 48, p. 29022-29034 (2015)
JAK1 and JAK3 are recurrently mutated in acute lymphoblastic leukemia. These tyrosine kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 receptor, in which JAK1 is appended to the specific chain, and JAK3 is appende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1deb3d95fd0dfca2ff6d4dc508b94953
https://hdl.handle.net/2078.1/166226
https://hdl.handle.net/2078.1/166226
Autor:
Yraima Cordeiro, Giulia D. S. Ferretti, Jerson L. Silva, Elen G. Pereira, Guilherme A. P. de Oliveira, Ana Paula Valente
Publikováno v:
The Journal of Biological Chemistry
Background: c-Abl regulates cell signaling and participates in leukemia pathogenesis via Bcr-Abl chimeric protein. Results: N-Cap and SH3 residues acquire μs-ms motions within the regulatory unit and membrane anchoring upon protein activation. Concl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135a7a6f127dfdf99a044c555e1cf144
https://pubmed.ncbi.nlm.nih.gov/23928308
https://pubmed.ncbi.nlm.nih.gov/23928308
Autor:
Rajeshwari R. Valiathan, Richard Arkwright, Hsueh Liang Fu, Malika Kumarasiri, Kiran V. Mahasenan, Gunjan Agarwal, Rafael Fridman, Shahriar Mobashery, Cosmin Mihai, Paul H. Huang, Anjum Sohail
The discoidin domain receptors (DDRs) are receptor tyrosine kinases that recognize collagens as their ligands. DDRs display unique structural features and distinctive activation kinetics, which set them apart from other members of the kinase superfam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfcce219831d0b11cb77e457bd0d770
https://hdl.handle.net/11541.2/121231
https://hdl.handle.net/11541.2/121231
Autor:
Sonia, Séverin, Alice Y, Pollitt, Leyre, Navarro-Nuñez, Craig A, Nash, Diego, Mourão-Sá, Johannes A, Eble, Yotis A, Senis, Steve P, Watson
Publikováno v:
The Journal of Biological Chemistry
The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6eca7efe8f24d514307f95b15ee630a4
https://pubmed.ncbi.nlm.nih.gov/21098033
https://pubmed.ncbi.nlm.nih.gov/21098033