A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection

Autor: Andrea Marzi, Junki Maruyama, Ayato Takada, Wakako Furuyama, Asuka Nanbo

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008602 (2020)

Besides the common Fc receptor (FcR)-mediated mechanism of antibody-dependent enhancement (ADE), Ebola virus (EBOV) is known to utilize the complement component C1q for ADE of infection. This mechanism is FcR-independent and mediated by cross-linking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77354c34a694da760463d2bed8c972e
http://europepmc.org/articles/PMC7497997

Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets

Autor: Meghna U. Naik, Ulhas P. Naik, Ross Summer, Tejal U. Naik

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0176602 (2017)
PLoS ONE

Background It is believed that activation of c-Src bound to the integrin β3 subunit initiates outside-in signaling. The involvement of αIIb in outside-in signaling is poorly understood. Objectives We have previously shown that CIB1 specifically int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e41d37cc44fd97b93b2e72456f7b25f
http://europepmc.org/articles/PMC5443481?pdf=render

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy

Autor: Chad J. Creighton, Sean M. Hartig, Ertug Kovanci, David W. Threadgill, Rainer B. Lanz, Michael A. Mancini, Jae Wook Jeong, Michael J. Large, Francesco J. DeMayo, John P. Lydon, Kuo-Fen Lee, Margeaux Wetendorf

Publikováno v: PLoS Genetics, Vol 10, Iss 6, p e1004451 (2014)
PLoS Genetics

Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61989ae7c438a4cf98c9e2ef5dacff3
http://europepmc.org/articles/PMC4063709?pdf=render

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement

Autor: Thomas E. Smithgall, John R. Engen, Thomas E. Wales, Roxana E. Iacob, Jodi K. Craigo, Jamie A. Moroco

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e105629 (2014)

Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a common negative regulatory mechanism that involves intramolecular interactions of the SH3 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dbc04beb00a305417171c95470019a
https://pubmed.ncbi.nlm.nih.gov/25144189

Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling

Autor: Gail, Doughton, Jun, Wei, Nicolas, Tapon, Melanie J, Welham, Andrew D, Chalmers

Publikováno v: PLoS ONE
Doughton, G, Wei, J, Tapon, N, Welham, M J & Chalmers, A D 2014, ' Formation of a polarised primitive endoderm layer in embryoid bodies requires Fgfr/Erk signalling ', PLoS ONE, vol. 9, no. 4, e95434 . https://doi.org/10.1371/journal.pone.0095434
PLoS ONE, Vol 9, Iss 4, p e95434 (2014)

The primitive endoderm arises from the inner cell mass during mammalian pre-implantation development. It faces the blastocoel cavity and later gives rise to the extraembryonic parietal and visceral endoderm. Here, we investigate a key step in primiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::44e981315f0244e48499a5f0ec15f1fe
http://europepmc.org/articles/PMC3994041