Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Tyrone Dowdy"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTR
Externí odkaz:
https://doaj.org/article/396aa9efafe945a9933a64c7527759d5
Autor:
Masaki Terabe, Jinkyu Jung, Masud Alam, Jenny Gumperz, Morgan Coombs, Tyrone Dowdy, Guzal Khayrullina, Vibhuti Joshi, Seketoulie Keretsu, Ayaka Hara, Kelsey Smith, Mioara Larion
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/05c507f23dd24a1d90a5101f79af92b6
Autor:
Victor Ruiz‐Rodado, Tyrone Dowdy, Adrian Lita, Tamalee Kramp, Meili Zhang, Jinkyu Jung, Ana Dios‐Esponera, Lumin Zhang, Christel C. Herold‐Mende, Kevin Camphausen, Mark R. Gilbert, Mioara Larion
Publikováno v:
Molecular Oncology, Vol 16, Iss 9, Pp 1777-1794 (2022)
Nutritional intervention is becoming more prevalent as adjuvant therapy for many cancers in view of the tumor dependence on external sources for some nutrients. However, little is known about the mechanisms that make cancer cells require certain nutr
Externí odkaz:
https://doaj.org/article/acc34fd6826b403ebb05348b9d91e052
Autor:
Victor Ruiz-Rodado, Tyrone Dowdy, Adrian Lita, Tamalee Kramp, Meili Zhang, Dorela Shuboni-Mulligan, Christel Herold-Mende, Terri S. Armstrong, Mark R. Gilbert, Kevin Camphausen, Mioara Larion
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Astrocytomas are the most common subtype of brain tumors and no curative treatment exist. Longitudinal assessment of patients, usually via Magnetic Resonance Imaging (MRI), is crucial since tumor progression may occur earlier than clinical progressio
Externí odkaz:
https://doaj.org/article/724348afb1f54e688c84cb1c615e4346
Autor:
Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report th
Externí odkaz:
https://doaj.org/article/1908125b7bca48998003ff46dab75493
Autor:
Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang, Christel Herold-Mende, Kylie J. Walters, Mark R. Gilbert, Mioara Larion
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Background Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1 mut ) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to th
Externí odkaz:
https://doaj.org/article/642fe869ab0144aeb501e954fc515524
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9255 (2022)
Gliomas are highly aggressive cancer types that are in urgent need of novel drugs and targeted therapies. Treatment protocols have not improved in over a decade, and glioma patient survival remains among the worst of all cancer types. As a result, ca
Externí odkaz:
https://doaj.org/article/f741ba1d5c4248c8a265b81929ca37be
Autor:
Nivedita M. Ratnam, Heather M. Sonnemann, Stephen C. Frederico, Huanwen Chen, Marsha-Kay N. D. Hutchinson, Tyrone Dowdy, Caitlin M. Reid, Jinkyu Jung, Wei Zhang, Hua Song, Meili Zhang, Dionne Davis, Mioara Larion, Amber J. Giles, Mark R. Gilbert
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glioblastoma (GBM) is an aggressive brain malignancy with a dismal prognosis. With emerging evidence to disprove brain-immune privilege, there has been much interest in examining immunotherapy strategies to treat central nervous system (CNS) cancers.
Externí odkaz:
https://doaj.org/article/c849550f38044b1bba008d2e7a7de887
Autor:
Amrita K Cheema, Irene Maier, Tyrone Dowdy, Yiwen Wang, Rajbir Singh, Paul M Ruegger, James Borneman, Albert J Fornace, Robert H Schiestl
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0151190 (2016)
Intestinal microbiota play a significant role in nutrient metabolism, modulation of the immune system, obesity, and possibly in carcinogenesis, although the underlying mechanisms resulting in disease or impacts on longevity caused by different intest
Externí odkaz:
https://doaj.org/article/3c6df41b6a4e48f2a87b3815cc1c74dc
Autor:
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106243 (2014)
The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone. Because mammals synthesize isoprenoids via an alternate pathway
Externí odkaz:
https://doaj.org/article/dd1996804d5d44a7a770cf35a3430aee