N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction.

Autor: Zaber J; Jagiellonian University, Doctoral School of Exact and Natural Sciences, prof. S. Lojasiewicza 11, 30-348 Krakow, Poland; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Skalniak L; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Gudz GP; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Hec-Gałązka A; Jagiellonian University, Doctoral School of Exact and Natural Sciences, prof. S. Lojasiewicza 11, 30-348 Krakow, Poland; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Zarnik M; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland., Tyrcha U; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Stec M; Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265, 30-663 Krakow, Poland., Siedlar M; Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265, 30-663 Krakow, Poland., Holak TA; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Sitar T; Recepton Sp. z o.o., ul. Trzy Lipy 3, 80-172 Gdansk, Poland., Muszak D; Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, 30-387 Krakow, Poland. Electronic address: damian.muszak@uj.edu.pl.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 15; Vol. 110, pp. 129882. Date of Electronic Publication: 2024 Jul 10.

IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins.

Autor: Mikitiuk M; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland.; Department of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdansk, Abrahama 58, 80-307 Gdańsk, Poland., Barczyński J; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland.; Department of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdansk, Abrahama 58, 80-307 Gdańsk, Poland., Bielski P; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland., Arciniega M; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland., Tyrcha U; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland., Hec A; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland., Lipińska AD; Laboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland., Rychłowski M; Laboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland., Holak TA; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland., Sitar T; Recepton Sp. z o.o., Trzy Lipy 3, 80-172 Gdańsk, Poland.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Nov 10; Vol. 28 (22). Date of Electronic Publication: 2023 Nov 10.