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Mechanism and Pathophysiology of Gastroesophageal Reflux Disease

Autor: Robin A. Zachariah, Tyralee Goo, Robert H. Lee

Publikováno v: Gastrointestinal Endoscopy Clinics of North America. 30:209-226

Gastroesophageal reflux (GER) describes a process in which gastric contents travel retrograde into the esophagus. GER can be either a physiologic phenomenon that occurs in asymptomatic individuals or can potentially cause symptoms. When the latter oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fddaebb8499c533f21e6887398be8dd
https://doi.org/10.1016/j.giec.2019.12.001

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The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease

Autor: Daisy E. Conduah, Maria T. Abreu, Keith J. Breglio, Anli Chen, Masayuki Fukata, Ruliang Xu, Arunan S. Vamadevan, Tyralee Goo, David Hsu

Publikováno v: The Journal of Immunology. 180:1886-1894

Abnormal T cell responses to commensal bacteria are involved in the pathogenesis of inflammatory bowel disease. MyD88 is an essential signal transducer for TLRs in response to the microflora. We hypothesized that TLR signaling via MyD88 was important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61a3b485f60de964ece6f8492e9c378f
https://doi.org/10.4049/jimmunol.180.3.1886

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Primary Prevention of Adverse Gastroduodenal Effects from Short-Term Use of Non-Steroidal Anti-Inflammatory Drugs by Omeprazole 20 mg in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Study

Autor: Lawrence B. Cohen, Tyralee Goo, Ariel A. Benson, Jay Desai, Carol A. Bodian, Kenneth M. Miller, Shefali Sanyal, James Aisenberg

Publikováno v: Digestive Diseases and Sciences. 53:2059-2065

The effectiveness of low-dose omeprazole as primary prevention of gastrointestinal adverse events due to episodic use of non-selective NSAIDs was evaluated. Healthy adults aged 50–75 who did not take chronic NSAIDs were randomized to a 6.5-day trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54edbfce76fffc741a1dd8328c8abed
https://doi.org/10.1007/s10620-007-0127-4

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Treating fibrosing cholestatic hepatitis C with sofosbuvir and ribavirin: a matched analysis

Autor: Myron J. Tong, Francisco Durazo, Melissa Jimenez, Ronald W. Busuttil, Steven Han, Tyralee Goo, Sherona Bau, Fady M. Kaldas, Mohammed El Kabany, Difan Zhao, Sammy Saab

Publikováno v: Clinical transplantation. 29(9)

Author(s): Saab, Sammy; Jimenez, Melissa; Bau, Sherona; Goo, Tyralee; Zhao, Difan; Durazo, Francisco; Han, Steven; El Kabany, Mohammed; Kaldas, Fady; Tong, Myron J; Busuttil, Ronald W | Abstract: BackgroundFibrosing cholestatic hepatitis (FCH) is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62609cfde4eb9e53f81dcf31d3915db
https://pubmed.ncbi.nlm.nih.gov/26147216

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Mechanisms of intragastric pH sensing

Autor: Jonathan D. Kaunitz, Yasutada Akiba, Tyralee Goo

Publikováno v: Current Gastroenterology Reports
Goo, Tyralee; Akiba, Yasutada; & Kaunitz, Jonathan D.(2010). Mechanisms of Intragastric pH Sensing. Current Gastroenterology Reports, 12(6), pp 465-470. doi: 10.1007/s11894-010-0147-7. Retrieved from: http://www.escholarship.org/uc/item/5j9171f6

Luminal amino acids and lack of luminal acidity as a result of acid neutralization by intragastric foodstuffs are powerful signals for acid secretion. Although the hormonal and neural pathways underlying this regulatory mechanism are well understood,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331d7fd7bcac4346f71e4395d02b123b
https://pubmed.ncbi.nlm.nih.gov/20938760

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Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury

Autor: Maria T. Abreu, Yasmín Hernández, Lory Hayes, Ruliang Xu, Anli Chen, Junsuke Maki, John P. Sotolongo, Tyralee Goo, Ryan C. Ungaro, Keith J. Breglio, Masayuki Fukata, David Hsu

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 90(9)

Epiregulin (EPI) and amphiregulin (AR) are epidermal growth factor receptor (EGFR) ligands implicated in mucosal repair and tumorigenesis. We have shown that Toll-like receptor 4 (TLR4) induces intestinal epithelial cell (IEC) proliferation by activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9d66dc127246b5d7a9160b2c22d0fc
https://pubmed.ncbi.nlm.nih.gov/20498653

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NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression

Autor: Andrew Dikman, Jay Desai, Kenneth M. Miller, Andrew Brooks, Masayuki Fukata, Maria T. Abreu, Shefali Sanyal, Tyralee Goo, Qi Wang, James Aisenberg, Lawrence B. Cohen

Publikováno v: Alimentary pharmacologytherapeutics. 30(1)

The basis for individual variation in gastroduodenal vulnerability to NSAIDs is not well understood.To assess whether a gene expression signature is associated with susceptibility to gastroduodenal ulcerations.Twenty-five Helicobacter pylori negative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90c8565380ca25c8b2e7680eeddfcfd
https://pubmed.ncbi.nlm.nih.gov/19309390

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Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

Autor: Jason P. Cohen, Daisy E. Conduah, David Hsu, Anli Chen, Ruliang Xu, Tyralee Goo, Yasmín Hernández, Keith J. Breglio, Maria T. Abreu, Masayuki Fukata

Publikováno v: Inflammatory bowel diseases. 15(7)

Background: Patients with ulcerative colitis are at increased risk for developing colorectal cancer. We have shown that Toll-like receptor-4 (TLR4) is overexpressed in human colitis-associated cancer (CAC) and that mice deficient in TLR4 are markedly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6399edfb5d80127a5e8d2cc01732aeb8
https://pubmed.ncbi.nlm.nih.gov/19229991

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