Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Type II topoisomerase"'
Publikováno v:
Archives of Biological Sciences, Vol 73, Iss 3, Pp 407-414 (2021)
Type II topoisomerases, including DNA gyrase (GyrA) and topoisomerase IV (ParC), contribute to fluoroquinolone resistance in Enterococcus spp. This study investigated the mutational status of the quinolone resistance-determining regions (QRDRs) of Gy
Externí odkaz:
https://doaj.org/article/d6f4e812001742928fc54fe66f8860fc
Akademický článek
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Publikováno v:
Molecules, Vol 25, Iss 14, p 3180 (2020)
Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-ch
Externí odkaz:
https://doaj.org/article/e1406949d185454395b3f313aa1ea90c
Akademický článek
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Publikováno v:
Archives of Biological Sciences, Vol 73, Iss 3, Pp 407-414 (2021)
Type II topoisomerases, including DNA gyrase (GyrA) and topoisomerase IV (ParC), contribute to fluoroquinolone resistance in Enterococcus spp. This study investigated the mutational status of the quinolone resistance-determining regions (QRDRs) of Gy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5552aa4da3077766123d2d3eb3bc645
https://doi.org/10.2298/abs210628034s
https://doi.org/10.2298/abs210628034s
Akademický článek
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Autor:
Ha Yun Jung, Yong-Seok Heo
Publikováno v:
Crystals, Vol 9, Iss 11, p 577 (2019)
Topoisomerase IV, one of the best-established antibacterial targets, is an enzyme crucial for chromosome segregation and cell division by catalyzing changes in DNA topology through breaking and rejoining DNA. This enzyme functions as a heterotetramer
Externí odkaz:
https://doaj.org/article/d3dfdb9c404a415db7a088f1f5be7e54
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:6939-6951
Plasmodium falciparum harbors a unique type II topoisomerase, Topoisomerase VIB (PfTopoVIB), expressed specifically at the actively replicating stage of the parasite. An earlier study showed that Radicicol inhibits the decatenation activity of PfTopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5014c660cd796a28527d08f88367534b
https://doi.org/10.1080/07391102.2021.1891970
https://doi.org/10.1080/07391102.2021.1891970
Autor:
Kyle M. Orritt, Lauren Abbott, Thomas Germe, Colin W. G. Fishwick, Anthony Maxwell, Juliette Newell, Holly Jackson, Martin J. McPhillie, Benjamin Bury
By 2050 it is predicted that antimicrobial resistance will be responsible for 10 million global deaths annually, costing the world economy $100 trillion. Clearly, strategies to address this problem are required as bacterial evolution is rendering our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67370c43bc395e9e07b0a1805633b0e
https://doi.org/10.26434/chemrxiv-2021-290nh-v2
https://doi.org/10.26434/chemrxiv-2021-290nh-v2
Fluoroquinolones are one of the most widely used class of antibiotics. They target two type II topoisomerase enzymes: gyrase and topoisomerase IV. Resistance to these drugs, which is largely caused by mutations in their target enzymes, is on the rise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f42fdf1ba19752d863be990c310b741
https://doi.org/10.1101/2021.09.24.461737
https://doi.org/10.1101/2021.09.24.461737