Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Type I IFNs"'
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Background Radiotherapy can modulate systemic antitumor immunity, while immune status in the tumor microenvironment also influences the efficacy of radiotherapy, but relevant molecular mechanisms are poorly understood in lung adenocarcinoma
Externí odkaz:
https://doaj.org/article/6bcfd859e16b49e493bba7b10b243443
Autor:
Maria Pujantell, Nikolaos-Taxiarchis Skenteris, Janna Marieke Claussen, Benjamin Grünhagel, Rebecca-Jo Thiele, Marcus Altfeld
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Natural killer (NK) cells are important antiviral effector cells and also involved in tumor clearance. NK cells express IFNAR, rendering them responsive to Type I IFNs. To evaluate Type I IFN-mediated modulation of NK cell functions, individual Type
Externí odkaz:
https://doaj.org/article/9fb70753e1bd49c698bbfbb5552c40fc
Publikováno v:
Viruses, Vol 16, Iss 5, p 749 (2024)
During viral infection, the innate immune system utilizes a variety of specific intracellular sensors to detect virus-derived nucleic acids and activate a series of cellular signaling cascades that produce type I IFNs and proinflammatory cytokines an
Externí odkaz:
https://doaj.org/article/5874c7345bf94d0fa457a139f0ff6145
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cyclic GMP-AMP synthetase (cGAS), recognized as the primary DNA sensor within cells, possesses the capability to identify foreign DNA molecules along with free DNA fragments. This identification process facilitates the production of type I IFNs throu
Externí odkaz:
https://doaj.org/article/501446a84a344174a44e86eb289e7be1
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4864-4881 (2023)
Abstract Introduction The activation of STING (stimulator of interferon genes) pathway enhances antitumor immunity in small‐cell lung cancer (SCLC), while the DNA damage induced by non‐cGAMP‐based agonists is a potent inducer of STING activity.
Externí odkaz:
https://doaj.org/article/d9bdfc988f4d4fe7b2c7d13f9b98e778
Autor:
Anuradha Rajamanickam, Nathella Pavan Kumar, Arul Nancy Pandiaraj, Nandhini Selvaraj, Saravanan Munisankar, Rachel Mariam Renji, Vijayalakshmi Venkatramani, Manoj Murhekar, Jeromie Wesley Vivian Thangaraj, Muthusamy Santhosh Kumar, Chethrapilly Purushothaman Girish Kumar, Tarun Bhatnagar, Manickam Ponnaiah, Ramasamy Sabarinathan, Velusamy Saravanakumar, Subash Babu
Publikováno v:
BMC Immunology, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background Plasmacytoid and myeloid dendritic cells play a vital role in the protection against viral infections. In COVID-19, there is an impairment of dendritic cell (DC) function and interferon secretion which has been correlated with dis
Externí odkaz:
https://doaj.org/article/3df44ab772b142d081670c52cd9bbe1c
Publikováno v:
Viruses, Vol 16, Iss 3, p 364 (2024)
Type I interferons (IFN), immediately triggered following most viral infections, play a pivotal role in direct antiviral immunity and act as a bridge between innate and adaptive immune responses. However, numerous viruses have evolved evasion strateg
Externí odkaz:
https://doaj.org/article/f8cd6651c266487883a1108555ba73f3
Akademický článek
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Akademický článek
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Autor:
Yuping Wang, Yang Gu, David F. Lewis, Xin Gu, Karisa Brown, Courtney Lachute, Miriam Hankins, Rona S. Scott, Caitlin Busada, Danielle B. Cooper, Charles E. McCathran, Perry Barrilleaux
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Background and objectiveCOVID-19 infection in pregnancy significantly increases risks of adverse pregnancy outcomes. However, little is known how the innate immunity at the placental maternal-fetal interface responds to COVID-19 infection. Type I IFN
Externí odkaz:
https://doaj.org/article/86643639aa334144aed0e32b9234b0e8