Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia.

Autor: Bai Z; Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Li P; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, and Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China., Gao X; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.; Shanghai Changning Mental Health Center, Shanghai, China.; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China., Zu G; Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Jiang A; Applied Translational Genetics Group, School of Biological Sciences, the University of Auckland, Auckland, New Zealand., Wu K; Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Mechawar N; McGill Group for Suicide Studies, Douglas Mental Health University Institute, Verdun, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Turecki G; McGill Group for Suicide Studies, Douglas Mental Health University Institute, Verdun, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Lehnert K; Applied Translational Genetics Group, School of Biological Sciences, the University of Auckland, Auckland, New Zealand., Snell RG; Applied Translational Genetics Group, School of Biological Sciences, the University of Auckland, Auckland, New Zealand., Zhou J; Shanghai Yangpu District Mental Health Center, Mental Health Center Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China., Hu J; Shanghai Yangpu District Mental Health Center, Mental Health Center Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China., Yan B; Neo-Biotechnology Limited Company, Shanghai, China., Chen L; Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Li W; Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Chen Y; Shanghai Yangpu District Mental Health Center, Mental Health Center Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai, China. yangpucy@163.com., Liu S; Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China. sliu@psy.ecnu.edu.cn.; Shanghai Changning Mental Health Center, Shanghai, China. sliu@psy.ecnu.edu.cn.; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China. sliu@psy.ecnu.edu.cn., Zhu Y; State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, and Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. ying_zhu@fudan.edu.cn., You L; Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China. lyyou@fudan.edu.cn.; Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Fudan University, Shanghai, China. lyyou@fudan.edu.cn.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2024 Dec 18; Vol. 14 (1), pp. 494. Date of Electronic Publication: 2024 Dec 18.

Computational analysis of natural compounds as potential phosphodiesterase type 5A inhibitors.

Autor: Uba AI; Department of Molecular Biology and Genetics, Istanbul AREL University, Istanbul 34537, Turkey., Paradis NJ; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, United States., Wu C; College of Science and Mathematics, Rowan University, Glassboro, NJ 08028, United States. Electronic address: wuc@rowan.edu., Zengin G; Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr.

Publikováno v: Computational biology and chemistry [Comput Biol Chem] 2024 Dec; Vol. 113, pp. 108239. Date of Electronic Publication: 2024 Oct 10.

Molecular analysis of inherited disorders of cornification in polish patients show novel variants and functional data and provokes questions on the significance of secondary findings.

Autor: Wertheim-Tysarowska K; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland. katarzyna.wertheim@imid.med.pl., Osipowicz K; Department of Dermatology, Immunodermatology and Venereology, Medical University of Warsaw, Warsaw, 02-008, Poland., Woźniak K; Department of Dermatology, Immunodermatology and Venereology, Medical University of Warsaw, Warsaw, 02-008, Poland.; National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland., Sawicka J; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Mika A; Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, 80-211, Poland., Kutkowska-Kaźmierczak A; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Niepokój K; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Sobczyńska-Tomaszewska A; Medgen - MedGen Diagnostic Laboratory, MedGen Medical Center, ul. Wiktorii Wiedeńskiej 9a, Warsaw, 02- 954, Poland., Wawrzycki B; Department of Dermatology, Venereology, and Paediatric Dermatology, Medical University of Lublin, Staszica 11, Lublin, 20-080, Poland., Pietrzak A; Department of Dermatology, Venereology, and Paediatric Dermatology, Medical University of Lublin, Staszica 11, Lublin, 20-080, Poland., Śmigiel R; Department of Pediatrics, Endocrinology, Diabetology and Metabolic Diseases, Wroclaw Medical University, Wroclaw, Poland., Wojtaś B; Laboratory of Sequencing, Nencki Institute of Experimental Biology, Wroclaw, Poland., Gielniewski B; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Wroclaw, Poland., Szabelska-Beresewicz A; Department of Mathematical and Statistical Methods, Poznań University of Life Sciences, Poznań, 60-637, Poland., Zyprych-Walczak J; Department of Mathematical and Statistical Methods, Poznań University of Life Sciences, Poznań, 60-637, Poland., Rygiel AM; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Domaszewicz A; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Braun-Walicka N; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Grabarczyk A; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Rzońca-Niewczas S; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Lidia R; Międzyleski Specialistic Hospital In Warsaw, Bursztynowa 2, Warsaw, 04-749, Poland., Dawidziuk M; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Domański D; Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Gambin T; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Jackiewicz M; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Duk K; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Dorożko B; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Szczygielski O; Clinic of Surgery of Children and Adolescents, Institute of Mother and Child, Warsaw, Poland., Krześniak N; Department of Plastic and Reconstructive Surgery, Centre of Postgraduate Medical Education, Prof. W. Orlowski Memorial Hospital, Warsaw, Poland., Noszczyk BH; Department of Plastic and Reconstructive Surgery, Centre of Postgraduate Medical Education, Prof. W. Orlowski Memorial Hospital, Warsaw, Poland., Obersztyn E; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Wierzba J; Department of Internal and Pediatric Nursing, Institute of Nursing and Midwifery, Medical University of Gdańsk, Gdańsk, Poland., Barczyk A; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Castaneda J; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Eckersdorf-Mastalerz A; Medical Center Fundacja PoMoc, ul. Dąbrowskiego 87, Łódź, 93-271, Poland., Jakubiuk-Tomaszuk A; Medical Genetics Unit, Mastermed Medical Center, Bialystok, Poland.; Department of Pediatric Neurology, Medical University of Bialystok, Bialystok, Poland., Własienko P; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Jaszczuk I; Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Lublin, Poland., Jezela-Stanek A; Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 26 Plocka str, Warsaw, 01-138, Poland., Klapecki J; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., van Geel M; Department of Dermatology, Maastricht University Medical Centre +, Maastricht, The Netherlands., Kowalewski C; Department of Dermatology, Immunodermatology and Venereology, Medical University of Warsaw, Warsaw, 02-008, Poland.; National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland., Bal J; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Gostyński A; Department of Dermatology, Maastricht University Medical Centre +, Maastricht, The Netherlands.

Publikováno v: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2024 Nov 05; Vol. 19 (1), pp. 413. Date of Electronic Publication: 2024 Nov 05.

Computational Investigation of the Therapeutic Potential of Detarium senegalense in the Management of Erectile Dysfunction.

Autor: Ejeje JN; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.; Department of Biochemistry, Faculty of Biological Sciences, Alex Ekwueme Federal University Ndufu Alike Ikwo, P.O. Box 1010, Abakaliki 480101, Nigeria., Agbebi EA; Institute of Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.; Department of Pharmacognosy and Natural Products, College of Pharmacy, Afe Babalola University, Ado-Ekiti 360001, Nigeria., Mathenjwa-Goqo MS; Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Oje OA; Department of Biochemistry, Faculty of Biological Sciences, Alex Ekwueme Federal University Ndufu Alike Ikwo, P.O. Box 1010, Abakaliki 480101, Nigeria., Agboinghale PE; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.; Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Ebe IT; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Uburu 491105, Nigeria., Obafemi TO; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria., Adewole E; Department of Chemical Sciences, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria., Omaka ON; Department of Chemistry, Faculty of Physical Sciences, Alex Ekwueme Federal University Ndufu Alike Ikwo, P.O. Box 1010, Abakaliki 480101, Nigeria., Onikanni SA; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria., Ajiboye BO; Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti 360101, Nigeria., Omotuyi OI; Institute of Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.; Department of Pharmacology and Toxicology, College of Pharmacy, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria., Oyinloye BE; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.; Institute of Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.; Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 18; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 18.

Intestinal fructose transporters GLUT5 and GLUT2 in children and adolescents with obesity and metabolic disorders.

Autor: Socha-Banasiak A; Department of Gastroenterology, Allergology and Pediatrics, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland. Electronic address: sochabanasiak@gmail.com., Sakowicz A; Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland., Gaj Z; Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland., Kolejwa M; Department of Gastroenterology, Allergology and Pediatrics, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland., Gach A; Department of Genetics, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland., Czkwianianc E; Department of Gastroenterology, Allergology and Pediatrics, Polish Mother's Memorial Hospital-Research Institute, Lodz, Poland.

Publikováno v: Advances in medical sciences [Adv Med Sci] 2024 Sep; Vol. 69 (2), pp. 349-355. Date of Electronic Publication: 2024 Jul 24.